Observing the CEE members of the EU (EU10 countries) from a distance, they certainly used to share major structural similarities given their historical legacies, as well as certain 'unifying' effects of their transition to market economy and democracy. Yet, a closer look reveals important elements of diversity in (a) the structure of their national innovation system, (b) the direction of recent structural changes, (c) innovation performance, and (d) patterns of business-academia collaboration. Given this diversity one would assume that fairly different needs are identified in the EU10 countries, necessitating differentiated, 'tailored' policy responses. Yet, these countries follow the same STI policy rationale, namely the market failure argument, which itself can be seen as a unifying force. Actually, this is not unique to the EU10 countries: the science-push model of innovation is still highly influential in the STI policy circles both at the level of the EC and the member states, despite a rich set of research insights stressing the importance of non-R&D types of knowledge in innovation processes.