The changing role of the pathologist in the era of targeted therapy in personalized medicine

D'Abbronzo, Giuseppe; Franco, Renato

doi:10.1080/23808993.2021.1923400

Cited by 5 publications

(2 citation statements)

References 22 publications

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“…The role of pathologists has evolved in this era of PM from just identifying and classifying tumors to playing an increasingly involved role in the clinical management of patients. Due to rapid development of technologies and range of different tests undertaken by the pathologists they are able to provide personalized and integrated information to the clinicians who can then provide tailored therapies to their patients ( 58 ).…”

Section: Identification Of Predictive Biomarkers In the Era Of Pmmentioning

confidence: 99%

Precision Medicine: An Optimal Approach to Patient Care in Renal Cell Carcinoma

et al. 2022

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Renal cell cancer (RCC) is a heterogeneous tumor that shows both intra- and inter-heterogeneity. Heterogeneity is displayed not only in different patients but also among RCC cells in the same tumor, which makes treatment difficult because of varying degrees of responses generated in RCC heterogeneous tumor cells even with targeted treatment. In that context, precision medicine (PM), in terms of individualized treatment catered for a specific patient or groups of patients, can shift the paradigm of treatment in the clinical management of RCC. Recent progress in the biochemical, molecular, and histological characteristics of RCC has thrown light on many deregulated pathways involved in the pathogenesis of RCC. As PM-based therapies are rapidly evolving and few are already in current clinical practice in oncology, one can expect that PM will expand its way toward the robust treatment of patients with RCC. This article provides a comprehensive background on recent strategies and breakthroughs of PM in oncology and provides an overview of the potential applicability of PM in RCC. The article also highlights the drawbacks of PM and provides a holistic approach that goes beyond the involvement of clinicians and encompasses appropriate legislative and administrative care imparted by the healthcare system and insurance providers. It is anticipated that combined efforts from all sectors involved will make PM accessible to RCC and other patients with cancer, making a tremendous positive leap on individualized treatment strategies. This will subsequently enhance the quality of life of patients.

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Section: Identification Of Predictive Biomarkers In the Era Of Pmmentioning

confidence: 99%

Precision Medicine: An Optimal Approach to Patient Care in Renal Cell Carcinoma

et al. 2022

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“…Surgical pathology has dramatically changed in the last decades. Indeed, the development of new technologies has led to the development of new fields such as advanced molecular pathology, digital pathology, automatization, and traceability systems, destined to develop further in the coming years 1 .…”

Section: Introductionmentioning

confidence: 99%

Shortage of pathologists in Italy: survey of students and residents

et al. 2023

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Summary Objective In Italy, shortage of pathologists is a problem that affects the quality of the National Health System (NHS). The cause of the shortage of pathologists in Italy must be sought in the lack of interests in the pathologist career by Medical Course Students (MCS) and in drop out of Post-Graduate Medical Schools (PGMS). We investigated reasons of both through two surveys. Methods We developed and proposed on Facebook two surveys, one to MCSs attending last years of study and one to Pathology School Residents (PSRs). Survey for MCSs consisted of 10 questions centered on their perception about pathologist activity; survey for PSRs consisted of 8 questions and investigated the most and least appreciated aspects of Italian PGMS. Results We obtained 500 responses from the MCSs and 51 responses from the PSRs. Our results show that lack of interest of MCS may be due to their incomplete knowledge of the pathologist’s activities. On the other hand, PSR answers show that some teaching aspects should be improved. Conclusions Our surveys showed that lack of interest of MCS in the pathology career depends on poor knowledge about the real clinical significance of pathology and PSRs believe that Italian PGMS do not meet their interest. One solution could be a renewal of teaching both in the pathology courses for MCS and in PGMS.

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