The characteristic histopathologic features of nevi on and around the ear

Lazova, Rossitza; Lester, Brian W.; Glusac, Earl J.; Handerson, Tamara; McNiff, Jennifer M.

doi:10.1111/j.0303-6987.2005.00263.x

Cited by 43 publications

(21 citation statements)

References 26 publications

(24 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…65 In a recent study, 101 junctional and compound nevi from the ear were studied. 66 These lesions were characterized by irregularity of nesting pattern, with nests that varied in size and shape and which were sometimes located between rete ridges. In addition, some of the lesions showed poor circumscription, lateral extension of the junctional component beyond the dermal component, and elongation of rete ridges with bridging between them.…”

Section: Nevi Of the Head And Neckmentioning

confidence: 99%

Precursors to melanoma and their mimics: nevi of special sites

2006

View full text Add to dashboard Cite

Melanocytic nevi, which are benign tumors of melanocytes, may have occasional cosmetic significance but, for the most part, they are important only in relation to melanoma. Nevi are the most important simulants of melanoma, both clinically and histologically, and can usually be reliably distinguished from melanomas using published criteria. Some lesions are characterized by greater degrees of atypia and may be more difficult to diagnose. Dysplastic nevi are among the most important simulants of melanoma. Nevi may also be important as potential precursors of melanoma; however, most nevi are stable and will not progress to malignancy. Nevi are vastly more common than melanomas and the rate of progression of individual lesions is very low. Therefore, nevi are not as a rule managed by wholesale excision to prevent melanoma. Nevi are also important as risk markers, identifying individuals at greater risk of developing melanoma in the future. Dysplastic nevi and, to a lesser extent, common acquired and congenital nevi are among the most important melanoma risk markers. Nevi of special sites have been identified as nevi that may show atypical features suggestive of a dysplastic nevus or of a melanoma. However, they are not risk markers and they are not malignancies. Nevi of genital skin, acral skin, and flexural skin are among the most important 'nevi of special sites'. It is important, in considering the differential diagnosis of a lesion in a special site, to avoid overcalling such a lesion as a melanoma or a dysplastic nevus because this could lead to excessive treatment. Conversely, it is important to avoid undercalling a lesion that is a dysplastic nevus or a melanoma as a nevus of special sites, because in this circumstance a patient could lose the opportunity either for surveillance to recognize a developing melanoma at an early, curable stage, or for definitive treatment of an established malignancy. In this monograph, dysplastic nevi and nevi of special sites are compared and contrasted in relation to melanoma.

show abstract

Section: Nevi Of the Head And Neckmentioning

confidence: 99%

Precursors to melanoma and their mimics: nevi of special sites

2006

View full text Add to dashboard Cite

show abstract

“…Even though they may show severe modifications their behavior is completely benign. the acral nevi tend to be more cellular than most of the nevi, with a predominant lentiginous than nested pattern and occasionally with pagetoid cells [8,9,10,15]. the nevi of the genitalia present with confluent melanocytic nests, with various sizes and shapes, and more discohesive melanocytes.…”

Section: Discussionmentioning

confidence: 99%

Morphologic analysis of periumbilical nevi

Nicolau¹,

Aşchie²

2013

ARS Medica Tomitana

View full text Add to dashboard Cite

A large number of publications recognize that there are melanocytic lesions with microscopic features similar to melanoma, related to their location, with no prognostic importance. those locations are represented by the ear, the milk lines (axillary, breast, periumbilical and inguinal regions), palms, soles and flexural regions. the periumbilical nevi are included by some authors in the category of the flexural nevi. In 2004, Rongioletti et al., performed a study on a number of 101 breast nevi, considering 10 histologic parameters. Starting from rongioletti's study we measured 10 histologic parameters on 121 nevi (26 from the periunmbilical area) and notes with 0 if absent or impossible to evaluate and with 1 if present. the score for each lesion ranged from 0 to 6 and we compared the features of the periumbilical nevi with the nevi from the control sites and found that the ones in the periumbilical area have more frequently atypical features than the nevi from the other sites (lemtiginous proliferation of nevus cells, architectural disorder of the nevus cell nests and stromal reactions as dermal fibroplasias and dermal lymphocytic infiltrate). We also performed immunohistochemical examination on lesions that presented three or more of

show abstract

“…There is little to suggest that stable moles in these special sites progress to melanoma or are markers for increased melanoma risk. [35][36][37][38][39][40][41][42][43][44] OPTIMAL BIOPSY TECHNIQUE Atypical/dysplastic nevi with no features suspicious for melanoma do not require biopsy. In contrast, any lesion suspicious for malignant melanoma must be removed, and it is reasonable to remove ''ugly ducklings'' (lesions that differ from the patient's signature pattern of moles).…”

Section: Are Atypical/dysplastic Nevi Precursors For Melanoma?mentioning

confidence: 99%