The Characteristics Analysis of a Microfluid-Based EGFET Biosensor with On-Chip Sensing Film for Lactic Acid Detection

Kuo, Po-Yu; Chang, Chun-Hung; Lai, Wei-Hao; Wang, Tai-Hui

doi:10.3390/s22155905

Cited by 6 publications

(2 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Other models that have also emerged are those with sequential detection windows, as reported by Kuo et al [61]. In this study, a device was made up of six aluminum metallic structures to prevent a measurement with only one recognition structure from collapsing the probe port and damaging the sensor (Figure 9).…”

Section: Devices With Non-electrical Counterpartsmentioning

confidence: 92%

The Integration of Field Effect Transistors to Microfluidic Devices

2023

View full text Add to dashboard Cite

Devices that integrate field effect transistors into microfluidic channels are becoming increasingly promising in the medical, environmental, and food realms, among other applications. The uniqueness of this type of sensor lies in its ability to reduce the background signals existing in the measurements, which interfere in obtaining good limits of detection for the target analyte. This and other advantages intensify the development of selective new sensors and biosensors with coupling configuration. This review work focused on the main advances in the fabrication and application of field effect transistors integrated into microfluidic devices as a way of identifying the potentialities that exist in these systems when used in chemical and biochemical analyses. The emergence of research on integrated sensors is not a recent study, although more recently the progress of these devices is more accentuated. Among the studies that used integrated sensors with electrical and microfluidic parts, those that investigated protein binding interactions seem to be the ones that expanded the most due, among other things, to the possibility of obtaining several physicochemical parameters involved in protein–protein interactions. Studies in this area have a great possibility of advancing innovations in sensors with electrical and microfluidic interfaces in new designs and applications.

show abstract

Section: Devices With Non-electrical Counterpartsmentioning

confidence: 92%

The Integration of Field Effect Transistors to Microfluidic Devices

2023

View full text Add to dashboard Cite

show abstract

“…While in an ISFET, the metal gate of the MOSFET is replaced by an ion-sensing film, an electrolyte solution, and a reference electrode, the EGFET retains the complete MOSFET structure, but the gate is extended for the connection to the metal-sensing film electrolyte solution and the reference electrode. Kuo and coworkers use CMOS technology to fabricate a biosensor for the detection of acid lactic [12]. The sensor uses an EGFET with a sensing window on an extended gate composed of a RuO 2 film sputtered on six metal layers and functionalized with lactase.…”

Section: Overview Of Contributionsmentioning

confidence: 99%

Advanced Field-Effect Sensors

Bartolomeo

2023

Sensors

View full text Add to dashboard Cite

show abstract

pH‑EGFET Sensor Based on the Surface Modification of MacroPSi with Au-NPs

Slewa

Sabah²,

Gozeh

et al. 2022

Silicon

View full text Add to dashboard Cite

A heterostructure of (Au-NPs/MacroPSi) was synthesized by filtering a colloidal of gold nanoparticles (Au-NPs) into MacroPSi layer using high voltage electrophoretic deposition (HVEPD). The aim of that is to enhance the performance of MacroPSi used as a pH-EGFET sensor. For this purpose, the MacroPSi with an average pore size of 1.388 μm was synthesized by anodic etching of Si wafer, and a spherical shape of Au-NPs with size varied in the range of 5 to 25 nm were synthesized in ethanol by pulsed laser ablation in liquid (PLAL) technique. The density of (Au-NPs) on the surface and inside the pores of MacroPSi was determined utilizing FESEM. The pH sensitivity, linearity, and hysteresis of the heterostructure Au-NPs/MacroPSi pH-EGFET sensor were measured in the pH range from 2 to 12. The outcomes indicated that the membrane exhibited a significantly enhanced pH sensitivity value of 83.57 mV/pH with linear regression of 99.37%, and hysteresis of 3 mV and 5 mV in the acid and base pH cycles, respectively. The presence of Au-NPs improve the sensitivity and stability of the sensor due to deactivate of the Si-h surface bond and enhancement the conducting on the surface of MacroPSi, and also provide better Ohmic contact to the PSi. The research work confirms the feasibility of using the hetero structures (Au-NPs/MacroPSi) as extended get for acidity and basicity detection.

show abstract

The Characteristics Analysis of a Microfluid-Based EGFET Biosensor with On-Chip Sensing Film for Lactic Acid Detection

Cited by 6 publications

References 51 publications

The Integration of Field Effect Transistors to Microfluidic Devices

The Integration of Field Effect Transistors to Microfluidic Devices

Advanced Field-Effect Sensors

pH‑EGFET Sensor Based on the Surface Modification of MacroPSi with Au-NPs

Contact Info

Product

Resources

About