2021
DOI: 10.7717/peerj.12193
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The characteristics and roles of antimicrobial peptides as potential treatment for antibiotic-resistant pathogens: a review

Abstract: The emergence of antibiotic-resistant bacteria has become a significant and ever-increasing threat to global public health, increasing both morbidity and mortality rates, and the financial burden on health services. Infection by drug-resistant bacteria is anticipated to contribute to the demise of almost 10 million people by the year 2050 unless a competent and effective response is devised to engage with this issue. The emergence and spread of resistance are commonly caused by the excessive or inappropriate u… Show more

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Cited by 18 publications
(8 citation statements)
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References 111 publications
(145 reference statements)
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“…It was also reported that Brevibacillus laterosporus produced brevibacillin against foodborne pathogenic bacteria and phytopathogenic fungi ( Wu et al, 2019 ). AMPs have emerged as potential alternatives to conventional antibiotics ( Zainal Baharin et al, 2021 ). Generally, AMPs have a net positive charge (+2 to +11), allowing an electrostatic interaction with negatively charged phospholipids in the bacterial membranes.…”
Section: Discussionmentioning
confidence: 99%
“…It was also reported that Brevibacillus laterosporus produced brevibacillin against foodborne pathogenic bacteria and phytopathogenic fungi ( Wu et al, 2019 ). AMPs have emerged as potential alternatives to conventional antibiotics ( Zainal Baharin et al, 2021 ). Generally, AMPs have a net positive charge (+2 to +11), allowing an electrostatic interaction with negatively charged phospholipids in the bacterial membranes.…”
Section: Discussionmentioning
confidence: 99%
“…The critical interaction points between the peptide and the bacterial membrane are electrostatic forces between the cationic AMPs and the negatively charged bacterial surface [ 28 , 29 , 30 ]. The cytoplasmic membranes of Gram-positive and Gram-negative bacteria are rich in phospholipids, phosphatidylglycerol, and cardiolipin, which have negatively charged major groups which strongly attract positively charged AMPs [ 1 , 31 ]. The cationic amphipathic α-helix is one of the most common types of AMP [ 25 ].…”
Section: Antimicrobial Peptidesmentioning
confidence: 99%
“…As global public health faces a looming crisis due to the emergence, evolution, and worldwide spread of antibiotic-resistant bacteria, alternative antibiotic agents with different mechanisms are urgently needed. At this conjuncture, antimicrobial peptides (AMPs), which selectively disrupt the bacterial cell’s membrane, captured attention as highly promising agents for combating drug-resistant bacteria [ 1 , 2 ]. In practice, the administration of AMPs, together with an adjunctive antibiotic, was the sole cure for some cases of infectious diseases, such as sepsis and skin infections [ 1 ].…”
Section: Introductionmentioning
confidence: 99%
“…At this conjuncture, antimicrobial peptides (AMPs), which selectively disrupt the bacterial cell’s membrane, captured attention as highly promising agents for combating drug-resistant bacteria [ 1 , 2 ]. In practice, the administration of AMPs, together with an adjunctive antibiotic, was the sole cure for some cases of infectious diseases, such as sepsis and skin infections [ 1 ]. Natural AMPs, which are characterized as genetically encoded endogenous antibiotic peptides, have been identified in all domains of life and protect the host from invading pathogens [ 3 , 4 , 5 ].…”
Section: Introductionmentioning
confidence: 99%