The characteristics of COVID-19 vaccine-related headache: Clues gathered from the healthcare personnel in the pandemic

Eki̇zoğlu, Esme; Gezegen, Haşim; Dikmen, Pınar Yalınay; Orhan, Elif Kocasoy; Ertaş, Mustafa; Baykan, Betül

doi:10.1177/03331024211042390

Cited by 40 publications

(71 citation statements)

References 35 publications

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“…Acute neurological deficits in the setting of recent mRNA COVID-19 vaccine administration may represent new-onset multiple sclerosis [ 25 ]. Headache was shown in 31% as presented in a prior study [ 26 ]. In this work, 16% of the subjects developed sleepliness post-vaccine.…”

Section: Discussionmentioning

confidence: 75%

Rheumatologists’ knowledge and perception of COVID-19 and related vaccines: the vaXurvey2 online survey

et al. 2022

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The study aimed to explore the experience of coronavirus disease-2019 (COVID-19) infection and vaccine adverse events (AEs) among rheumatologists. A validated questionnaire was distributed as a Google form to rheumatologists across the country via social networking sites from late December 2021 till early January 2022. The questionnaire included questions regarding participants' socio-demographic details, COVID-19 infection and vaccination details with special emphasis on AEs. Out of 246 responses, 228 were valid. 200 (81.3%) responders had received the vaccine. The mean age of the 228 participants was 37.9 ± 8.5 years, 196 were females and 32 males (F:M 6.1:1) from 18 governorates across the country. Comorbidities were present in 54 subjects (27%). There was a history of highly suspicious or confirmed COVID-19 infection in 66.7% that were all managed at home. The COVID-19 vaccine was received by 200 and a booster dose of 18.5%. Obesity and musculoskeletal involvement co-morbidities were present only in those with AEs (9.1% and 5.5% respectively). AEs were present in 82%; 66.7% had injection-site tenderness, 50% fatigue, 35.5% fever, 15% chills, 42.5% myalgia, 14.5% arthralgia, 8% low back pain, headache 31%, dizziness 10%, sleepliness 16% and 15% developed post-vaccine. There were no differences according to the geolocation regarding the occurrence of COVID-19 infection ( p = 0.19) or AEs post-vaccine ( p = 0.58). The adverse events were mostly mild to moderate and tolerable which makes this work in agreement with other studies that support the broad safety of the vaccine in favor of the global benefit from mass vaccination. Supplementary Information The online version contains supplementary material available at 10.1007/s00296-022-05130-3.

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Section: Discussionmentioning

confidence: 75%

Rheumatologists’ knowledge and perception of COVID-19 and related vaccines: the vaXurvey2 online survey

et al. 2022

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“…The presences of headache symptoms may be related to the type of vaccine used in this study that is inactivated virus vaccine. The association of inactivated virus vaccine has been highlighted by Ekizoglu et al 2021. An inactivated viral vaccine is containing alum, an aluminum salt–based adjuvant.…”

Section: Resultsmentioning

confidence: 99%

Post COVID-19 1^st Dose Vaccination Common Symptoms among SE Asia College Students

Wibowo

Yostyadiananda

Gunawan

2021

Preprint

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In the second year of the COVID-19 epidemic in the Southeast Asia (SE) regions, there is a plan to reopen the school, including the campus. Among students in Indonesia, college students have a population of almost 8.3 million. Considering the massive numbers of college students, school reopening should be supported by adequate COVID-19 vaccination. As a result, the first dose of the inactivated virus COVID-19 vaccine has been administered, including to college students aged over 18 years old. While COVID-19 vaccination is widely available, there is still a scarcity of information on post-vaccination symptoms. As reported from other locations, post vaccination has been reported. Then, this study aims to assess the common symptoms of COVID-19 1st dose vaccinations among the following groups: gender (male and female college students), age, body weight, and height. The observed symptoms include sore arms, fatigue, headache, fever with a body temperature above 38 oC, nausea, shivering, and muscle joint pain. Participants in this study were students at the university. They were considered eligible for this study if they were currently enrolled at university, were at least 19 years of age, and provided informed consent. The data was recorded using a standardized online questionnaire. The answers were collected in an online database. At the beginning of the questionnaire, subjects or students were informed that data would be collected anonymously. Based on the results, the symptoms were different between female and male students. In fact, female students have experienced more symptoms than male students. While male students only suffered sore arms (68%) followed by headache symptoms (32%). Similar to male students, sore arms are the most common symptom observed among female students. Among female students, from the most to the least common symptoms observed from 20 years of age in this study are sore arms at site reaction > headache > fatigue > fever > muscle joint pain > shivering > nausea. A higher risk of presenting fatigue and headache symptoms was found in those with a non-overweight status with weight ranges of 50-60 kg.

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“…Patterns similar to COVID-19 can be observed in cases of vaccine-related headache. Headache occurs early after vaccination [89][90][91][92] and is often accompanied by other systemic symptoms (i.e. myalgia and fever [91]).…”

Section: Post-vaccination Headachementioning

confidence: 99%

“…Headache occurs early after vaccination [89][90][91][92] and is often accompanied by other systemic symptoms (i.e. myalgia and fever [91]). Similarly to COVID-19, headache after vaccination has more often a TTH phenotype, with migraine-like features present in one third of cases.…”

Section: Post-vaccination Headachementioning

confidence: 99%

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COVID-19-related headache and innate immune response — a narrative review

Straburzyński

Kuca-Warnawin

Waliszewska‐Prosół

2023

Neurol Neurochir Pol.

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Headache is one of the most prevalent, although often underreported, symptoms of coronavirus disease 2019 . It is generally accepted that this symptom is a form of secondary headache due to systemic viral infection. There are several hypotheses that try to explain its aetiopathogenesis. One of the most compelling is related to innate immune response to viral infection. This rationale is supported by similarities to other viral infections and the temporal overlap between immunological reactions and headache. Moreover, several key factors in innate immunity have been shown to facilitate headache e.g. interferons, interleukin (IL) -1-β, IL-6, and tumour necrosis factor. There is also a possibility that the virus causes headache by the direct activation of afferents through pattern recognition receptors (i.e. Toll-like receptor 7). Moreover, some data on post-COVID-19 headache and after vaccination against SARS-CoV-2 infection suggests a similar cytokine-mediated pathomechanism in these clinical situations. Future research should look for evidence of causality between particular immune response factors and headache. Identifying key molecules responsible for headache during acute viral infection would be an important step towards managing one of the most prevalent secondary headache disorders.

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The characteristics of COVID-19 vaccine-related headache: Clues gathered from the healthcare personnel in the pandemic

Cited by 40 publications

References 35 publications

Rheumatologists’ knowledge and perception of COVID-19 and related vaccines: the vaXurvey2 online survey

Rheumatologists’ knowledge and perception of COVID-19 and related vaccines: the vaXurvey2 online survey

Post COVID-19 1^st Dose Vaccination Common Symptoms among SE Asia College Students

COVID-19-related headache and innate immune response — a narrative review

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The characteristics of COVID-19 vaccine-related headache: Clues gathered from the healthcare personnel in the pandemic

Cited by 40 publications

References 35 publications

Rheumatologists’ knowledge and perception of COVID-19 and related vaccines: the vaXurvey2 online survey

Rheumatologists’ knowledge and perception of COVID-19 and related vaccines: the vaXurvey2 online survey

Post COVID-19 1st Dose Vaccination Common Symptoms among SE Asia College Students

COVID-19-related headache and innate immune response — a narrative review

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Product

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Post COVID-19 1^st Dose Vaccination Common Symptoms among SE Asia College Students