The current study aimed to measure the level of some immunological parameters (IgG, IgM, and IgA) among women trained in aerobic exercises in fitness halls in the holy city of Karbala. The study was conducted for the period from 1/12/2021 to 1/3/2022. Blood was drawn from healthy women before the exercises and after completing the exercises prepared for the test in order to compare the results. The results showed that the studied levels of immunoglobulins increased in the serum significantly below the level of P < 0.05 after daily aerobic exercise. The value of IgG was (613.7000), IgM (5.95207), and IgA (123.1900) after it was before exercise (610.6920), (74.8600) and (120.9780) for the immunological standards IgG, IgM, and IgA, respectively. We conclude from the results of this study that exercise Moderate exercise on a daily basis has an effect in stimulating and increasing the activity of the immune system by increasing the level of immunoglobulins in the blood plasma, which enhances defenses against diseases by continuing daily sports activities.