The Characteristics of Quick Contrast Sensitivity Function in Keratoconus and Its Correlation with Corneal Topography

Abstract

Introduction: To characterize quick contrast sensitivity function (qCSF) in keratoconus and its correlation with corneal topographic parameters. Methods: Patients with keratoconus (n = 120) who visited the Fudan Eye and ENT Hospital between April and June 2021 were enrolled in our study. A total of 215 eyes were subdivided into three groups according to maximum keratometry (K max ): Group 1 (K max B 48 D, 74 eyes), Group 2 (48 D \ K max B 55 D, 64 eyes), and Group 3 (K max [ 55 D, 77 eyes). Manifest refraction, best corrected distance visual acuity (BCVA), corneal topography, and the qCSF test were examined. Intergroup comparisons and correlations among various corneal topographic parameters and qCSF were analyzed. Results: Significant differences in the area under the log CSF (AULCSF) and CSF Acuity among the three groups were found, which decreased with an increase in K max . Contrast sensitivity (CS) between spatial frequencies of 3.0 to 18.0 cpd was significantly different (all P \ 0.05) between Groups 1 and 2. The CS at all spatial frequencies was significantly different (all P \ 0.05) between Group 3 and other two groups. At 3.0-18.0 cpd, CS decreased significantly (all P \ 0.05) in Groups 1-3. Manifest Yiyong Xian and Ling Sun contributed equally and should therefore both be regarded as first authors.