The characteristics of serum circulating immune complexes of patients with atopic asthma with different severity degree

Skibo, Yulia V.; Курмаева, Н. Ш.; Tsibulkina, V. N.; Мустафин, И Г; Zi, Abramova

doi:10.17816/kmj1934

Cited by 4 publications

(8 citation statements)

References 7 publications

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“…At the same time, the pathogenicity coefficient (C4/C3 ratio) in patients was 2 times higher mainly due to the increase in low molecular weight complexes, which worse than complement large complexes activate complement, as a result of which they circulate for a long time blood, are deposited in organs and tissues, causing inflammation or suppression of the immune system [16]. A significant increase in the level of small and medium circulating immune complexes is observed in acute processes and correlates with the severity of the disease [16].…”

Section: Resultsmentioning

confidence: 99%

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The pathogenetic aspects of acute intestinal infections of suckling piglets

et al. 2020

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According to the studies piglets with intestinal infections compared to the clinically healthy animals, have lower the content of total protein, gamma globulins and general immunoglobulins, higher levels of malondialdehyde and endogenous intoxication, low molecular weight circulating immune complexes, lysozyme and complementary blood serum activity, phagocytic activity of neutrophils, their absorption and metabolic ability with a low functional reserve of phagocytes. The revealed changes in the biochemical, antioxidant, and immune status should be considered one of the pathogenetic mechanisms of the complex process of inflammation, as well as their diagnostic value in case of intestinal pathology caused by bacteria.

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Section: Resultsmentioning

confidence: 99%

“…The content of large (3 %), medium (3.5 %) and small (4 %) circulating immune complexes (CIC), total protein, proteinogram [15] pathogenicity coefficient of CIC (C4 / C3 ratio) [16] and total immunoglobulins (Ig) [17].…”

Section: Methodsmentioning

confidence: 99%

The pathogenetic aspects of acute intestinal infections of suckling piglets

et al. 2020

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“…В сыворотке крови свиней определяли содержание общего белка, белковых фракций, циркулирующих иммунных комплексов (ЦИК): крупных (3%), средних (3,5%) и мелких (4%) согласно «Методическим рекомендациям по оценке и коррекции иммунного статуса животных» [15], количество общих иммуноглобулинов (Ig) [16], коэффициент патогенности ЦИК (отношение С4 / С3) [17]. Титры антител к A. рleuropneumoniae определяли с помощью иммуноферментного анализа (ИФА) с последующим учетом результатов на спектрофотометре «Униплан-ТМ» в соответствии с наставлением к диагностическому набору ID Screen® APP Screening Indirect (Франция).…”

Section: материалы и методыunclassified

Immune status improvement in piglets through the use of interferon-containing products during specific prevention of porcine pleuropneumonia

Shakhov

Sashnina

Прокулевич

et al. 2021

Veterinariâ segodnâ

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Specific prevention is one of the most effective methods for the control of infectious diseases causing considerable economic damage to commercial pig farms, among which is porcine pleuropneumonia. In order to improve the effectiveness of preventive vaccination, various immunomodulators that differ in their origin and mechanism of action are used. The paper presents the results of the study of the effect of such products as biferon-S and prostimul containing species-specific recombinant interferons on the immune status of piglets during specific prevention of porcine pleuropneumonia. Tests were carried out in clinically healthy 30–35-day-old piglets immunized with Ingelvac® APPX vaccine (Boehringer Ingelheim Vetmedica GmbH, Germany). It was found that the use of biferon-S and prostimul together with the vaccine administration is accompanied by immune status improvement in the animals, which is manifested as an increase, in comparison with vaccinated animals that received no interferon-containing products (base case), in serum levels of γ-globulins – by 34.6 and 53.7% (in case of prostimul and β-globulins – by 10.1%), total immunoglobulins – by 32.8 and 37.8%, large circulating immune complexes – by 37.5 and 52.6%, a less significant increase in the levels of small complexes and, as a result, pathogenicity coefficient reduction by 5.4 and 12.4%, respectively. Tests for post-vaccination immunity levels in piglets showed a 3.8-fold increase in the levels of specific antibodies against the antigen of porcine pleuropneumonia agent, and in case of the vaccine administration in combination with biferon-S and prostimul – a 4.0-fold and 4.9-fold increase, respectively. The use of prostimul was accompanied by a more considerable improvement of immune status in the piglets, and this is attributable to the fact that vitamins А, Е and С, which have antioxidant properties and improve the effectiveness of interferons, natural resistance and specific immunity, are included in its composition in addition to recombinant type 1 cytokine.

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“…One of the most important functions of immunoglobulins (antibodies) is antigen binding and the formation of immune complexes, which should result in neutralization or elimination of the antigen [10]. Normally, circulating immune complexes (CICs) are rapidly eliminated from the blood.…”

Section: Introductionmentioning

confidence: 99%

“…At the same time, CICs often play an important role in the pathogenesis of the disease, and their long-term circulation in the organism correlates with the duration and severity of the pathological process. This is especially true for small and medium CICs, an increase in the blood level of which may indicate a predisposition to the development of immunopathological states [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

State of humoral immunity in lactating sows and suckling piglets

et al. 2021

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The state of humoral immunity in lactating sows and its formation in suckling piglets in the conditions of a pig-breeding complex were studied. In sows after farrow, a high content of total immunoglobulins, the main classes of IgG, IgM and IgA, the concentration of which decreased in a day, followed by an increase in serum as lactation continued was detected in the serum and colostrum. In piglets at birth, the content of total immunoglobulins and the main Ig isotypes was insignificant, and at the age of twenty-four hours, as a result of absorption of colostral immunoglobulins in the small intestine, their amount in the serum was the highest, followed by a decrease in the concentration of IgG and IgA until the end of the suckling period, and IgM - up to day 14 with a further increase in its content, indicating the formation of a primary immune response. It has been detected that the dominant class of immunoglobulins in the serum and colostrum of sows and the serum of piglets is IgG, and in milk - IgA. An increase in the level of medium-dispersed circulating immune complexes (C4%) and their relation to giant (C3%) CICs was revealed, associated with an increase of the antigenic load in sows in the second half of lactation as a result of immunization, in milk - with a decrease in the content of the main classes of immunoglobulins, and in piglets, due to this, with a decrease in passive immunity.

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The characteristics of serum circulating immune complexes of patients with atopic asthma with different severity degree

Cited by 4 publications

References 7 publications

The pathogenetic aspects of acute intestinal infections of suckling piglets

The pathogenetic aspects of acute intestinal infections of suckling piglets

Immune status improvement in piglets through the use of interferon-containing products during specific prevention of porcine pleuropneumonia

State of humoral immunity in lactating sows and suckling piglets

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