The aim of this study was to analyze the health status of the population in Central Serbia, in order to identify priority health problems. For data source, authors used reports about diseases, conditions and injuries, recorded in services for the health care of preschool children, services for school health, health care services for the adult population and services for the health care of women's health centers in Central Serbia in 2015. On the territory of Central Serbia, leading cause of morbidity in children of preschool and school age are diseases of the respiratory system. Cardiovascular diseases and respiratory diseases dominate in the structure of morbidity in the adult population, as well as high blood pressure as a single disease, while in the female population the most common are diseases of genitourinary tract.