The characteristics of the serum carcinoembryonic antigen and carbohydrate antigen 19-9 levels in gastric cancer cases

Wada, Noriko; Kurokawa, Yukinori; Miyazaki, Yasuhiro; Makino, Tomoki; Takahashi, Tsuyoshi; Yamasaki, Makoto; Nakajima, Kiyokazu; Takiguchi, Shuji; Mori, Masaki; Doki, Yuichiro

doi:10.1007/s00595-016-1408-3

Cited by 45 publications

(36 citation statements)

References 22 publications

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“…In the present study, GCs with high serum CA19‐9 levels showed distinct clinicopathological features such as advanced stage, higher recurrence rate, lymphatic permeation, higher rate of distant metastasis and higher T classification. These results are in accordance with data reported by other investigators . Thus, our results, together with those reported up to date, highly support the notion that CA19‐9‐positive GCs have a poor prognosis, and that CA19‐9 is an important predictor for tumor recurrence risk.…”

Section: Discussionsupporting

confidence: 93%

Clinicopathological characteristics of gastric cancer with carbohydrate antigen 19‐9 expression occurring in elderly individuals: An autopsy study

Wang

Matsuda

Nonaka

et al. 2019

Pathology International

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gastric cancer (GC) remains obscure. Therefore, the current study aimed to clarify the clinicopathological value of CA19-9 in GC utilizing autopsy cases.We examined the expression of CA19-9 and mucin core proteins in GC immunohistochemically, and analyzed serum CA19-9 levels and clinicopathological variables or complications. We also investigated whether fucosyltransferases 2 and 3 (FUT2/3) allelic variants influence CA19-9 expression in GC. Compared to GC cases with negative CA19-9 expression (tCA19-9-N), those with positive CA19-9 expression (tCA19-9-P) demonstrated significant differences in characteristic features such as lymph node and distant organ metastases, lymphatic and venous permeation, and higher Tumor, Node, Metastasis (TNM) stages. Moreover, compared to GC cases with low serum CA19-9 levels (sCA19-9-L), those with high serum CA19-9 levels (sCA19-9-H) were related to venous permeation, higher proportion of lymph node and distant organ metastases, and higher TNM stages.Both tCA19-9-P GC and sCA19-9-H GC cases were significantly associated with coagulation abnormalities. sCA19-9-H GC cases correlated significantly with MUC1 and MUC5AC expression. FUT2/3 genotypes were not associated with CA19-9 expression in GC. These results suggest that CA19-9 can predict the risk of lymph node and distant metastases as well as of coagulation abnormalities.

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Section: Discussionsupporting

confidence: 93%

Clinicopathological characteristics of gastric cancer with carbohydrate antigen 19‐9 expression occurring in elderly individuals: An autopsy study

Wang

Matsuda

Nonaka

et al. 2019

Pathology International

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“…From other researches, CA125 was associated with R0 resection rate [13], recurrence and peritoneal dissemination [14] and OS in the unresectable advanced or recurrent GC patients [15]; CA199 was related to pN[7, [16][17][18] and pTNM stage [17], and CA724 possessed the larger area under the receiver operating curve, which meant a higher diagnostic efficiency [19]. However, none of their patients underwent NCT.…”

Section: Discussionmentioning

confidence: 99%

“…With regard to the pathological factors, we found that CA199, CA125 and CA724 before and after NCT were all predict indicators for lymph node metastasis and ypTNM stage. In the previous articles, in GC patients who experienced curative gastrectomy, preoperative CA199 could predict the lymph node metastasis [17,18] and the pTNM stage [17]. CA724 was associated with nodal involvement[9] and worse stage in advanced gastric cancer patients [19].…”

Section: Discussionmentioning

confidence: 99%

CA724 predicts overall survival in locally advanced gastric cancer patients with neoadjuvant chemotherapy

Tong

Zhao

Shan

et al. 2020

Preprint

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Background: Serum tumor markers are of great importance in diagnosis, prognostic predicting and recurrence monitoring in gastrointestinal malignancy, including AFU, AFP, CEA, CA199, CA125 and CA724. However, their significances in gastric cancer (GC) patients with neoadjuvant therapy (NCT) are still uncertain. The aim of this study is to evaluate the predictive value of these six tumor markers in locally advanced GC patients with NCT and curative surgery. Methods: 290 locally advanced GC patients with NCT and D2 radical gastrectomy were retrospectively analyzed. Their tumor markers before (pre-) and after (post-) NCT and pathological characters were exacted from the database in our hospital. The optimal cutoff values of six tumor markers were calculated by ROC and Youden index. Their predictive significances were analyzed and survival curves on overall survival (OS) were obtained by Kaplan-Meier method. Associations between categorical variables were explored by Chi-square test or Fisher's exact method. Multivariate analyses were performed by Cox regression model. Results: Not only the pre- and post- CA199, CA125 and CA724 could predict the OS respectively, but also the changes (diff-) between post- and pre- groups were related to the prognosis (P < 0.05). In multivariable analysis, only pre- (P = 0.016) and post-CA724 (P = 0.033) remained significant, and the significance of diff-CA724 was on borderline (P = 0.085). Besides, pre- and post-CA199, CA125 and CA724 were associated with the metastasis of lymph node (N- vs N+) and pathological stage (Ⅰ-Ⅱ vs Ⅲ) (P < 0.05). Post-CA724 was related to the invasion of vascular or lymphatic vessels (P = 0.019), and pre-CA724 was nearly remarkable (P = 0.082). However, AFU, AFP and CEA showed no association with survival (P > 0.05). Conclusions: CA724 is an independent factor to prognosis, and could be used to predict the ypN and ypTNM stage in locally advanced GC patients undergone NCT and curative resection.

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“…Other studies have shown that, CA125 was associated with the R0 resection rate [13], recurrence, peritoneal dissemination [14] and OS in unresectable advanced or recurrent GC patients [15]; CA199 was related to pN [7,[16][17][18] and pTNM stage [17]; and CA724 was related to the pathological stage and had a good diagnostic value for gastric cancer [19]. However, none of the patients in those studies underwent NCT.…”

Section: Discussionmentioning

confidence: 95%

CA724 predicts overall survival in locally advanced gastric cancer patients with neoadjuvant chemotherapy

Tong

Zhao

Shan

et al. 2020

Preprint

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Background: Serum tumor markers including AFU, AFP, CEA, CA199, CA125 and CA724, are of great importance in the diagnosis, prognostic prediction and recurrence monitoring of gastrointestinal malignancies. However, their significance in gastric cancer (GC) patients with neoadjuvant therapy (NCT) is still uncertain. The aim of this study was to evaluate the predictive value of these six tumor markers in locally advanced GC patients who underwent NCT and curative surgery. Methods: In total, 290 locally advanced GC patients who underwent NCT and D2 radical gastrectomy were retrospectively analyzed. Data on their tumor markers before (pre-) and after (post-) NCT and pathological characteristics were extracted from the database of our hospital. The optimal cutoff values of the six tumor markers were calculated by the ROC curve and Youden index. Their predictive significance was analyzed and survival curves for overall survival (OS) were obtained by the Kaplan-Meier method. Associations between categorical variables were explored by the chi-square test or Fisher's exact test. Multivariate analyses were performed by the Cox regression model. Results: Pre- and post-CA199, -CA125 and -CA724 could predict overall survival (all P < 0.05), but only the change (diff-) of CA199 was related to prognosis (P = 0.05). In the multivariable analysis, pre- (P = 0.014) and post-CA724 (P = 0.036) remained significant, though diff-CA724 was not an independent prognostic factor (P = 0.581). In addition, pre- and post-CA199, -CA125 and -CA724 were associated with lymph node metastasis (N- vs N+) and pathological stage (Ⅰ-Ⅱ vs Ⅲ) (all P < 0.05). Moreover, post-CA724 was related to the vascular or lymphatic invasion (P = 0.019), while pre-CA724 was not (P = 0.082). However, AFU, AFP and CEA showed no association with survival (P > 0.05). Conclusions: CA724 is an independent factor for prognosis and could be used to predict ypN and ypTNM stage in locally advanced GC patients undergoing NCT and curative resection.

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The characteristics of the serum carcinoembryonic antigen and carbohydrate antigen 19-9 levels in gastric cancer cases

Cited by 45 publications

References 22 publications

Clinicopathological characteristics of gastric cancer with carbohydrate antigen 19‐9 expression occurring in elderly individuals: An autopsy study

Clinicopathological characteristics of gastric cancer with carbohydrate antigen 19‐9 expression occurring in elderly individuals: An autopsy study

CA724 predicts overall survival in locally advanced gastric cancer patients with neoadjuvant chemotherapy

CA724 predicts overall survival in locally advanced gastric cancer patients with neoadjuvant chemotherapy

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