The characterization and dissolution performances of spray dried solid dispersion of ketoprofen in hydrophilic carriers

Chan, Siok-Yee; Chung, Yin-Ying; Cheah, Xin-Zi; Tan, Eryn Yen-Ling; Quah, Joan

doi:10.1016/j.ajps.2015.04.003

Cited by 78 publications

(68 citation statements)

References 34 publications

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“…ATR-FTIR spectrum of KP indicates 2 main bands centered at 1,695 and 1,654 cm , which corresponds to the C=O stretching of the carbonyl group. [40][41][42] The fingerprint region shows a triplet in the region of 703 cm −1…”

Section: Atr-ftir Analysismentioning

confidence: 99%

“…Both findings speak for crystalline nature of KP used in the study. 42 The medium-weak, multiple bands located in region 1,400-1,600 cm −1 correspond to the presence of an aromatic core.…”

Section: Atr-ftir Analysismentioning

confidence: 99%

“…[41][42][43] It indicates the presence of a physical mixture of KP and the polymer carriers with the existence of a weak H-bonding between OH-group (from -COOH). Disappearance, displacement and low intensity of KP characteristic absorption peaks in the spectra of KP-pVAc+HPC and KP-p(VAc-co-DMAEMC) assumes a lower drug content in these carriers compared with KP-pVAc, KP-pVAc+CH, and KP-pVAc+Cbp.…”

Section: Atr-ftir Analysismentioning

confidence: 99%

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Ketoprofen-loaded polymer carriers in bigel formulation: an approach to enhancing drug photostability in topical application forms

Andonova¹,

Peneva²,

Georgiev³

et al. 2017

IJN

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The purpose of the study was to investigate the stability and biopharmaceutical characteristics of ketoprofen, loaded in polymeric carriers, which were included into a bigel in a semisolid dosage form. The polymer carriers with in situ-included ketoprofen were obtained by emulsifier-free emulsion polymerization of the monomers in aqueous medium or a solution of the polymers used. The morphological characteristics of the carriers, the in vitro release and the photochemical stability of ketoprofen were evaluated. The model with optimal characteristics was included in a bigel formulation. The bigel was characterized in terms of pH, rheological behavior, spreadability, and in vitro drug release. Acute skin toxicity, antinociceptive activity, anti-inflammatory activity, and antihyperalgesic effects of the prepared bigel with ketoprofen-loaded polymer carrier were evaluated. The carriers of ketoprofen were characterized by a high yield and drug loading. The particle size distribution varied widely according to the polymer used, and a sustained release was provided for up to 6 hours. The polymer mixture poly(vinyl acetate) and hydroxypropyl cellulose as a drug carrier, alone or included in the bigel composition, improved the photostability of the drug compared with unprotected ketoprofen. The bigel with ketoprofen-loaded particles provided sustained release of the drug and had optimal rheological parameters. In vivo experiments on the bigel showed no skin inflammation or irritation. Four hours after its application, a well-defined analgesic, anti-inflammatory, and antihyperalgesic effect was registered. The polymer mixture of poly(vinyl acetate) and hydroxypropyl cellulose as a carrier of ketoprofen and the bigel in which it was included provided an enhanced photostability and sustained drug release.

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Section: Atr-ftir Analysismentioning

confidence: 99%

Section: Atr-ftir Analysismentioning

confidence: 99%

Section: Atr-ftir Analysismentioning

confidence: 99%

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Ketoprofen-loaded polymer carriers in bigel formulation: an approach to enhancing drug photostability in topical application forms

Andonova¹,

Peneva²,

Georgiev³

et al. 2017

IJN

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“…Muitos ingredientes farmacêuticos ativos disponíveis atualmente possuem baixa solubilidade em água, o que diminui sua biodisponibilidade quando administrados via oral (CHAN et al, 2015). Atualmente, mais de 40% das novas entidades químicas (NEQ) desenvolvidas na indústria farmacêutica são praticamente insolúveis em água (MALODE et al, 2014).…”

Section: Encapsulação De Cetoprofeno Por Atomizaçãounclassified

“…Atualmente, mais de 40% das novas entidades químicas (NEQ) desenvolvidas na indústria farmacêutica são praticamente insolúveis em água (MALODE et al, 2014). Estas drogas são classificadas, de acordo com o Sistema de Classificação Biofarmacêutica (SCB), como classe II, baixa solubilidade e alta permeabilidade, ou classe IV, baixa solubilidade e baixa permeabilidade (CHAN et al, 2015). A permeabilidade referese à capacidade de passagem do fármaco através da parede do trato gastrointestinal humano (PARAISO, 2012).…”

Section: Encapsulação De Cetoprofeno Por Atomizaçãounclassified

Síntese e caracterização de copolímeros em blocos biocompatíveis do tipo poli (N-vinilcaprolactama)-b-poli(etileno glicol) para encapsulação do cetoprofeno utilizando a técnica de secagem por atomização

Souza¹

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Influence of screw configuration and processing parameters on the dissolution of ketoprofen in polymer blends

Restrepo‐Uribe

Ioannidis²,

Escobar³

2020

J of Applied Polymer Sci

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The solubility and dissolution enhancement of the poorly soluble drug ketoprofen (KTO) in polymer blends prepared by hot melt extrusion was studied using two different screw configurations while changing extrusion processing conditions. A number of different Soluplus and Kollidon SR blends were used as solid dispersion excipients. A design of experiments with three melt temperatures, three screw rotation speeds, and three fill factors was performed, and a phase‐gate methodology was implemented. Different characterization techniques such as differential scanning calorimetry, optical and polarized light microscopy, X‐ray diffraction, solid‐state nuclear magnetic resonance, and dissolution testing were used. The results from differential scanning calorimetry and X‐ray diffraction showed an amorphous solid solution. The characterization by solid‐state nuclear magnetic resonance indicated that KTO could interact with the polymer blend by hydrogen bonds and Van der Waals forces. An optimal processing window was found for each screw configuration achieving more than 80% drug release in 8 hr.

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The characterization and dissolution performances of spray dried solid dispersion of ketoprofen in hydrophilic carriers

Cited by 78 publications

References 34 publications

Ketoprofen-loaded polymer carriers in bigel formulation: an approach to enhancing drug photostability in topical application forms

Ketoprofen-loaded polymer carriers in bigel formulation: an approach to enhancing drug photostability in topical application forms

Síntese e caracterização de copolímeros em blocos biocompatíveis do tipo poli (N-vinilcaprolactama)-b-poli(etileno glicol) para encapsulação do cetoprofeno utilizando a técnica de secagem por atomização

Influence of screw configuration and processing parameters on the dissolution of ketoprofen in polymer blends

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