The Characterization of Polyaspartic Acid and Some Related Compounds^1,2

Abstract

July 5, 1058 CHARACTERIZATION OF POLYASPARTIC ACID 3331 tri-peptide is hydrolyzed. It may be that the products of hydrolysis have an inhibitory effect on the further conversion or possibly, but improbably, there is an equilibrium between the di-DNP-Val-his and the unrecognized product.

Part 8. Preparation, characterization and metal complexing of poly[(2-hydroxyethyl)-DL-aspartamide] in aqueous solution

“…The polyreaction of aspartic acid has been studied previously in detail using different procedures ranging from simply heating aspartic acid for 2±4 h at 200°C in an open tube 16 to heating under a high vaccum for 120 h, 17 or by using phosphoric acid as an additive. 18 In this study, polymer 2 was synthesized by polycondensation of aspartic acid in the presence of 80 % phosphoric acid under reduced pressure in quantitative yield.…”

Some Early Historical Aspects of the Thermal Polycondensation of Amino Acids

“…Polyaspartic acid which was obtained by heating of aspartic acid was also studied (Vegotsky et al, 1958). The structure of the polymer was confirmed as anhydropolyaspartic acid by infra-red absorption spectra at 1780, 1710 cm-1 , which are characteristic of five-membered imide structures.…”

Thermal Synthesis of Polypeptides from N-Butyloxycarbonyl Oligopeptides Containing Aspartyl Residue at C-Terminus

“…Numerous reports on the methodology for the synthesis of polypeptides have been published [1][2][3][4][5][6][7][8][9][10][11][12][13][14]. The N-carboxyl--amino acid anhydride (NCA) method (1) [2,3,9,10], polymerization of amino acids using active esters (2) [1,[4][5][6][7], solid-phase peptide synthesis (3) [8,12], and the heating of amino acids (4) [13,14] are typical examples. The NCA method (1) is suitable for making homopolypeptides and random copolypeptides but is not suitable for the synthesis of sequential copolyamino acid, which is more important for the build-up of functional polypeptides.…”

“…However, the problems of methods (2) and (3) are a long reaction time and the use of much solvent. In contrast, the synthesis of polyamino acid by heating a derivative of the amino acid (4) [13,14] requires neither long reaction time nor solvents.…”