The characterization of purified citrate-coated cerium oxide nanoparticles prepared via hydrothermal synthesis

Hancock, Matthew L.; Yokel, Robert A.; Beck, Matthew J.; Calahan, Julie L.; Jarrells, Travis W.; Munson, Eric J.; Olaniyan, George A.; Grulke, Eric A.

doi:10.1016/j.apsusc.2020.147681

Cited by 38 publications

(26 citation statements)

References 86 publications

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“…90% Ce 4+ (Figure 2), consistent with nanoceria calcined at T ≥ 400 °C [18]. In contrast, the surface of the solvothermally synthesized nanoceria exhibits primarily Ce 3+ (Figure 3b of [35]). TGA showed an average weight loss from 20 to 400 °C of ca.…”

Section: Physicochemical Characterization Of Nm-212supporting

confidence: 69%

“…The product was dialyzed against 110 mM pH 7.4 citric acid for 120 h, replacing the dialysate every 24 h, then dialyzed against DI water to remove citric acid and ionic cerium for an additional 72 h, replacing the dialysate every 24 h. The product was extensively characterized. It was a citrate-coated 4.2 nm ceria [35]. Lanthanides (LN) resin (100 to 150 μm) was obtained from Eichrom Technologies LLC, Lisle, IL, 60532.…”

Section: Experimental Materialsmentioning

confidence: 99%

“…TEM, conducted at a higher resolution than previously reported, showed NM-212 to be crystalline and cubic or triangular with clearly defined edges (Figure 1). The solvothermally synthesized nanoceria is also crystalline but hexagonal and smaller (Figure 1b of [35]). The estimated diameter and variability of NM-212 (Table 1) are consistent with prior reports (Supporting Information File 1, Table S1) and the size is consistent with nanoceria calcined at temperatures above 600 °C [15][16][17].…”

Section: Physicochemical Characterization Of Nm-212mentioning

confidence: 99%

“…The TGA weight loss for the solvothermally synthesized nanoceria was much greater (ca. 15%) due to its citrate coating (Figure 8 of [35]). FTIR, not previously reported for NM-212, showed small peaks at ca.…”

Section: Physicochemical Characterization Of Nm-212mentioning

confidence: 99%

“…1630, 1420, and 1320 cm −1 , attributed to N-O, -COOH, or hydroxy groups; probably COOH and the stretching mode of O-H bonds; and either -CH or C-O-C, respectively [16,49,50] (Figure 4). Due to the citrate coating on the solvothermally synthesized nanoceria, the FTIR spectrum shows additional large peaks at 1535 and 1365 cm −1 (Figure 10 of [35]). EDS showed co-localization of not only cerium and oxygen for both NM-212 (Figure 1) and the solvothermally synthesized nanoceria (Figure 2 of [35]), but also carbon, as previously reported [7], and sodium (Figure 1) were found.…”

Section: Physicochemical Characterization Of Nm-212mentioning

confidence: 99%

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The preparation temperature influences the physicochemical nature and activity of nanoceria

Yokel

Wohlleben

Keller

et al. 2021

Beilstein J. Nanotechnol.

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Cerium oxide nanoparticles, so-called nanoceria, are engineered nanomaterials prepared by many methods that result in products with varying physicochemical properties and applications. Those used industrially are often calcined, an example is NM-212. Other nanoceria have beneficial pharmaceutical properties and are often prepared by solvothermal synthesis. Solvothermally synthesized nanoceria dissolve in acidic environments, accelerated by carboxylic acids. NM-212 dissolution has been reported to be minimal. To gain insight into the role of high-temperature exposure on nanoceria dissolution, product susceptibility to carboxylic acid-accelerated dissolution, and its effect on biological and catalytic properties of nanoceria, the dissolution of NM-212, a solvothermally synthesized nanoceria material, and a calcined form of the solvothermally synthesized nanoceria material (ca. 40, 4, and 40 nm diameter, respectively) was investigated. Two dissolution methods were employed. Dissolution of NM-212 and the calcined nanoceria was much slower than that of the non-calcined form. The decreased solubility was attributed to an increased amount of surface Ce4+ species induced by the high temperature. Carboxylic acids doubled the very low dissolution rate of NM-212. Nanoceria dissolution releases Ce3+ ions, which, with phosphate, form insoluble cerium phosphate in vivo. The addition of immobilized phosphates did not accelerate nanoceria dissolution, suggesting that the Ce3+ ion release during nanoceria dissolution was phosphate-independent. Smaller particles resulting from partial nanoceria dissolution led to less cellular protein carbonyl formation, attributed to an increased amount of surface Ce3+ species. Surface reactivity was greater for the solvothermally synthesized nanoceria, which had more Ce3+ species at the surface. The results show that temperature treatment of nanoceria can produce significant differences in solubility and surface cerium valence, which affect the biological and catalytic properties of nanoceria.

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Section: Physicochemical Characterization Of Nm-212supporting

confidence: 69%

Section: Experimental Materialsmentioning

confidence: 99%

Section: Physicochemical Characterization Of Nm-212mentioning

confidence: 99%

Section: Physicochemical Characterization Of Nm-212mentioning

confidence: 99%

Section: Physicochemical Characterization Of Nm-212mentioning

confidence: 99%

See 3 more Smart Citations

The preparation temperature influences the physicochemical nature and activity of nanoceria

Yokel

Wohlleben

Keller

et al. 2021

Beilstein J. Nanotechnol.

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Mesoporous Cerium Oxide Nanoparticles with High Scavenging Properties of Reactive Oxygen Species for Treating Age‐Related Macular Degeneration

Choi,

Kim,

Kim

2023

Advanced NanoBiomed Research

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Age‐related macular degeneration (AMD), the leading cause of vision loss among older individuals, is characterized by damage to photoreceptors and retinal pigment epithelial cells (RPEs). Oxidative stress and chronic inflammation in the retina play notable roles in AMD pathogenesis, rendering them attractive therapeutic targets. Cerium oxide nanoparticles (CeNPs) have shown promise in scavenging reactive oxygen species (ROS) by mimicking antioxidant enzymes, whereas mesoporous materials have emerged as versatile drug carriers. Herein, mesoporous CeNPs (mCeNPs) that integrate the advantages of CeNPs and mesoporous materials are presented. The mCeNPs can be synthesized using 1,1′‐carbonyldiimidazole and imidazole in acetone without heating and pressurization. The resulting mCeNPs exhibit mesoporous structures comprising assembled small CeNPs, exerting excellent ROS‐scavenging capabilities, biocompatibility, and cytoprotective and anti‐inflammatory effects against H2O2‐induced damage in RPEs. Using a sodium iodate‐induced AMD mouse model, it is demonstrated that intravitreal mCeNP administration can exhibit disease‐preventive effects. These findings indicate the therapeutic potential of mCeNPs against AMD.

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Regulation of the Oxidase Mimetic Activity of Ceria Nanoparticles by Buffer Composition

Yang

et al. 2023

Chemistry A European J

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Ceria nanoparticles (CNPs) are important typical nanozymes with multiple enzyme mimetic activities, which could facilitate the oxidation of organic dyes in acidic conditions, because of the oxidase mimetic activity. Usually, the regulation of oxidase mimetic activity is focused on the adjustment of the structure, morphology, composition, surface, and other factors of nanozymes. However, the influence of the surrounding environment is not considered, which is very important during the reaction process. In this work, the oxidase mimetic activity of CNPs in buffer solutions including citric acid, acetic acid and glycine buffer solutions was investigated, with the results that carboxyl group in buffer solution could adsorb the CNPs on the surface to promote the oxidase mimetic activity. Due to the chelation with the cerium ion, the enhancement is more significant by molecules with polycarboxylic groups, and the enhancement is more efficient by carboxyl molecules in buffer solution, compared with the modification of the carboxyl groups on the surface, because of easier operation and smaller steric hindrance. From the viewpoint of increasing the oxidase mimetic activity of CNPs, the work is expected to provide references for the selection of the reaction systems to optimize the oxidase mimetic activity in bio‐detection applications.

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The characterization of purified citrate-coated cerium oxide nanoparticles prepared via hydrothermal synthesis

Cited by 38 publications

References 86 publications

The preparation temperature influences the physicochemical nature and activity of nanoceria

The preparation temperature influences the physicochemical nature and activity of nanoceria

Mesoporous Cerium Oxide Nanoparticles with High Scavenging Properties of Reactive Oxygen Species for Treating Age‐Related Macular Degeneration

Regulation of the Oxidase Mimetic Activity of Ceria Nanoparticles by Buffer Composition

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