The Chemical Characterization of Nigerian Propolis samples and Their Activity Against Trypanosoma brucei

Omar, Ruwida; Igoli, John O.; Zhang, Tong; Gray, Alexander I.; Ebiloma, Godwin U.; Clements, Carol; Fearnley, James; Edrada-Ebel, RuAngelie; Paget, Tim; Koning, Harry P. de; Watson, David

doi:10.1038/s41598-017-01038-2

Cited by 56 publications

(71 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Then, they add salivary enzymes to the resins and mix it with beeswax, thereby forming propolis. Thus, the chemical composition of propolis varies with the geographical region, season, surrounding flora, and bee species [13,14,27,[29][30][31][32]. Over 500 chemical compounds have been identified from various samples of propolis from different regions and seasons [27,33].…”

Section: The Chemistry Of Propolismentioning

confidence: 99%

“…Owing to its long use in traditional medicine for treatment of infectious diseases and its reported antimicrobial activities [13,14], the chemical compositions and properties of propolis from diverse locations and floral origins are now being intensely investigated. Many scientific studies on propolis samples from different botanical sources, geographical regions, and seasons of collection have reported its pharmacological activities with results that point to its therapeutic potential against diseases caused by kinetoplastids [14][15][16][17][18][19][20][21][22][23][24]. This review contributes to this growing body of knowledge by bringing together the chemistry of propolis and its pharmacological activities, including its mode of action against the kinetoplastids.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Strong Anti-Kinetoplastid Properties of Bee Propolis: Composition and Identification of the Active Agents and Their Biochemical Targets

et al. 2020

Self Cite

View full text Add to dashboard Cite

The kinetoplastids are protozoa characterized by the presence of a distinctive organelle, called the kinetoplast, which contains a large amount of DNA (kinetoplast DNA (kDNA)) inside their single mitochondrion. Kinetoplastids of medical and veterinary importance include Trypanosoma spp. (the causative agents of human and animal African Trypanosomiasis and of Chagas disease) and Leishmania spp. (the causative agents of the various forms of leishmaniasis). These neglected diseases affect millions of people across the globe, but drug treatment is hampered by the challenges of toxicity and drug resistance, among others. Propolis (a natural product made by bees) and compounds isolated from it are now being investigated as novel treatments of kinetoplastid infections. The anti-kinetoplastid efficacy of propolis is probably a consequence of its reported activity against kinetoplastid parasites of bees. This article presents a review of the reported anti-kinetoplastid potential of propolis, highlighting its anti-kinetoplastid activity in vitro and in vivo regardless of geographical origin. The mode of action of propolis depends on the organism it is acting on and includes growth inhibition, immunomodulation, macrophage activation, perturbation of the cell membrane architecture, phospholipid disturbances, and mitochondrial targets. This gives ample scope for further investigations toward the rational development of sustainable anti-kinetoplastid drugs.

show abstract

Section: The Chemistry Of Propolismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Strong Anti-Kinetoplastid Properties of Bee Propolis: Composition and Identification of the Active Agents and Their Biochemical Targets

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…Metabolomic profile data have been utilized to distinguish diverse propolis from different geographic origins. Numerous metabolomic research works on the chemical compositions of propolis by various techniques, including thin layer chromatography [23], high-performance liquid chromatography (HPLC) [24], ultra-high-performance liquid chromatography coupled with mass spectrometry [25], and gas chromatography coupled with mass spectrometry [26], have been reported. The NMR technology as a significant spectroscopic method with fast, robust, reproducible, and non-destructive features can provide the unbiased structural information of organic samples.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, simple sample pretreatment, good stability, and short analysis time make it more suitable for high-throughput analysis. Recently, NMR-based metabolomics analysis was applied to a variety of propolis to study the characteristics and classification of southern Brazilian propolis [18], Nigerian propolis [24], as well as the discrimination of five regions: Asia, Brazil, Europe, Africa, and the Solomon Islands [27].…”

Section: Introductionmentioning

confidence: 99%

Metabolomics Reveals Discrimination of Chinese Propolis from Different Climatic Regions

Wang

Liu

Wang

et al. 2020

Foods

View full text Add to dashboard Cite

The chemical profiles of propolis vary greatly due to the botanic sources and geographic origins, which limit its standardization for modern usages. Here, we proposed a reliable 1H NMR-based metabolomic approach, to discriminate the function and quality of Chinese propolis. A total 63 Chinese propolis samples from different temperate regions were collected and extracted for NMR analysis. Twenty-one compositions in ethanol extracts were assigned based on characteristic chemical shifts and previous literature reports. Significant geographic indicators were identified after the PCA and orthogonal partial least squares discriminant analysis (OPLS-DA) analysis of the obtained 1H NMR data. It was found that the composition discriminations arose from long-term acclimation of the different climates of botanic origin and caused the differences in the biological activities. This study provides us a reasonable instruction for the quality control of Chinese propolis.

show abstract

“…Gentiatibetine has certain anticonvulsant and brain protective effects (Peng 2016), gingediol (curcumin) could be used to treat cold and vomiting (Hatcher et al 2008), amarasterone A can reduce blood sugar (Catalan et al 1982), linolenic acid has been suggested to have antitumor properties (Huan et al 2012). Houpu lignan A has therapeutic effects on dyspepsia, abdominal distention, constipation and also has certain anti-cancer properties (Si et al 2002), albopetasin can relieve swelling and pain (Zhang 2009), ginsenoyne K could invig-orate the spleen and benefit the lung (He et al 1993), ambonic acid has antibacterial effect (Omar et al 2017), 7-hydroxycadalenal can relieve pain (State Administration of Traditional Chinese Medicine 2005), etc. These activities may attribute to the function of fermented Pinelliae Rhizoma.…”

mentioning

confidence: 99%

Microbiota and Chemical Compounds in Fermented Pinelliae Rhizoma (Banxiaqu) from Different Areas in the Sichuan Province, China

Shu

Ying

Wang

et al. 2019

Polish Journal of Microbiology

View full text Add to dashboard Cite

This study focused on the microbiota and chemical compounds of the fermented Pinelliae Rhizoma produced in Longchang (LC), Zizhong (ZZ) and Xindu (XD), in Sichuan Province (China). High-throughput sequencing was used to analyze the microbiota. GC-MS and LC-MS were used to detect the compounds produced during the three different Pinelliae Rhizoma fermentation processes. The bacteria and fungi of the three fermented Pinelliae Rhizoma differed substantially, with the bacterial content mainly composed of the Bacillus genus, while the common fungi were only included in four OTUs, which belong to three species of Eurotiomycetes and Aspergillus cibarius. 51 volatile compounds were detected; they varied between LC, XD, and ZZ fermented Pinelliae Rhizoma. C10 and C15 terpenes were most frequently detected, and only curcumene and β-bisabolene were detected in the three fermented Pinelliae Rhizoma. 65 non-volatile compounds were detected by LC-MS, most were of C16, C18, C20, C21 and C22 structures. Cluster analysis showed more similarity between LC and XD fermented Pinelliae Rhizoma with regards to volatile compound content, but more similarity between the XD and ZZ fermented Pinelliae Rhizoma for non-volatiles. Moreover, no correlation between geographical distance and microflora or compounds of fermented Pinelliae Rhizoma was observed. These results showed that hundreds of compounds are produced by the natural mixed fermentation of Pinelliae Rhizoma, and may mostly relate to the microorganisms of five species. K e y w o r d s: Fermented Pinelliae Rhizoma, components, microbiota, regions Shu B. et al.

show abstract

The Chemical Characterization of Nigerian Propolis samples and Their Activity Against Trypanosoma brucei

Cited by 56 publications

References 30 publications

The Strong Anti-Kinetoplastid Properties of Bee Propolis: Composition and Identification of the Active Agents and Their Biochemical Targets

The Strong Anti-Kinetoplastid Properties of Bee Propolis: Composition and Identification of the Active Agents and Their Biochemical Targets

Metabolomics Reveals Discrimination of Chinese Propolis from Different Climatic Regions

Microbiota and Chemical Compounds in Fermented Pinelliae Rhizoma (Banxiaqu) from Different Areas in the Sichuan Province, China

Contact Info

Product

Resources

About