The chemical composition of the aerial parts of Stachys spreitzenhoferi (Lamiaceae) growing in Kythira Island (Greece), and their antioxidant, antimicrobial, and antiproliferative properties

Napolitano, Assunta; Castagliuolo, Giusy; Badalamenti, Natale; Cicio, Adele; Bruno, Maurizio; Piacente, Sonia; Maresca, Viviana; Cianciullo, Piergiorgio; Capasso, Lucia; Bontempo, Paola; Varcamonti, Mario; Basile, Adriana

doi:10.1016/j.phytochem.2022.113373

Cited by 23 publications

(13 citation statements)

References 82 publications

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“…This assay was performed according to the reported method [47], with some modifications, which are based on ABTS radical cation scavenging. Then, 1 mL ABTS solution was added to 100 µL of EO (1; 10; 100; 200, and 250 µg/mL concentrations).…”

Section: Abts Scavenging Capacity Assaymentioning

confidence: 99%

Antimicrobial, Antibiofilm, and Antioxidant Properties of Essential Oil of Foeniculum vulgare Mill. Leaves

Castagliuolo

Badalamenti

Maresca

et al. 2022

Plants

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Foeniculum vulgare (Apiaceae) is an aromatic fennel with important practices in medicinal and traditional fields, used in the treatment of digestive complications, and gastrointestinal and respiratory disorders. Its leaves and stems, tender and fresh, are used in the production of pasta dressing and main courses, while its seeds, with a strong smell of anise, are excellent flavoring for baked goods, meat dishes, fish, and alcoholic beverages. The aim of this work is concerning the extraction of essential oil (EO) from the leaves of F. vulgare subsp. vulgare var. vulgare, investigating antimicrobial, antibiofilm, and antioxidant efficacy. In particular, GC-MS analysis showed how the chemical composition of EO was influenced by the massive presence of monoterpene hydrocarbons (α-pinene 33.75%) and phenylpropanoids (estragole 25.06%). F. vulgare subsp. vulgare var. vulgare EO shows excellent antimicrobial activity against both Gram-positive and Gram-negative strains. This EO can inhibit biofilm formation at very low concentrations and has a good ability to scavenge oxygen radicals in vitro. F. vulgare subsp. vulgare var. vulgare EO also has an increased activity of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) enzymes and decreased ROS levels in zymosan opsonized PMNs (OZ).

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Section: Abts Scavenging Capacity Assaymentioning

confidence: 99%

Antimicrobial, Antibiofilm, and Antioxidant Properties of Essential Oil of Foeniculum vulgare Mill. Leaves

Castagliuolo

Badalamenti

Maresca

et al. 2022

Plants

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“…Furthermore, PC showed the occurrence of flavonols at higher intensity levels than PD (Table 4). Flavan-3-ols (20 and 34) and proanthocyanidins A-type (49,56) occurred in all tested extracts, even if at lower intensity in PD, which lacked the dimers of proanthocyanidins B-type (11, 16, and 23), which were, in turn, more evident in PF than in PC (Table 4). Glycosylated derivatives of cyanidin and delphinidin (10, 12, 15, 45, and 48) could be observed in PF, PC, and PD, with PC showing the occurrence of the rutinoside derivatives of both anthocyanins (15 and 45) at a minor intensity level.…”

Section: Lc-hrms Analysismentioning

confidence: 95%

“…The LC-HRMS profiles of the PC, PD, and PF extracts highlighted the occurrence of several metabolites in P. cerasifera, the structures of which could be assigned by a comparison between the molecular formulae, fragmentation patterns, and retention times and the literature data and metabolite databases, allowing us to putatively identify hydroxycinnamic acid derivatives, flavonols, flavan-3-ols and proanthocyanidins, anthocyanins, organic acids, sugar alcohols (and their derivatives), glycosylated hydroxybenzaldehyde and benzylic alcohol derivatives, glycosyl terpenates, and glycosylated aliphatic alcohol derivatives (Table 4) [37,[49][50][51][52][53][54]. Except for compounds 28 and 67, which were previously described in the Rosaceae family [55,56] but not in the genus Prunus, and for compounds 35, 36, 43, and 54 described in families other than Rosaceae [57][58][59], to the best of our knowledge, most of these compounds have already been detected in plants belonging to the genus Prunus [60][61][62][63][64][65][66][67][68][69][70][71][72][73] but not in the species cerasifera.…”

Section: Lc-hrms Analysismentioning

confidence: 99%

A New Bloody Pulp Selection of Myrobalan (Prunus cerasifera L.): Pomological Traits, Chemical Composition, and Nutraceutical Properties

Sottile

Napolitano

Badalamenti

et al. 2023

Foods

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A new accession of myrobalan (Prunus cerasifera L.) from Sicily (Italy) was studied for the first time for its chemical and nutraceutical properties. A description of the main morphological and pomological traits was created as a tool for characterization for consumers. For this purpose, three different extracts of fresh myrobalan fruits were subjected to different analyses, including the evaluation of total phenol (TPC), flavonoid (TFC), and anthocyanin (TAC) contents. The extracts exhibited a TPC in the range 34.52–97.63 mg gallic acid equivalent (GAE)/100 g fresh weight (FW), a TFC of 0.23–0.96 mg quercetin equivalent (QE)/100 g FW, and a TAC of 20.24–55.33 cyanidine-3-O-glucoside/100 g FW. LC-HRMS analysis evidenced that the compounds mainly belong to the flavonols, flavan-3-ols, proanthocyanidins, anthocyanins, hydroxycinnamic acid derivatives, and organic acids classes. A multitarget approach was used to assess the antioxidant properties by using FRAP, ABTS, DPPH, and β-carotene bleaching tests. Moreover, the myrobalan fruit extracts were tested as inhibitors of the key enzymes related to obesity and metabolic syndrome (α-glucosidase, α-amylase, and lipase). All extracts exhibited an ABTS radical scavenging activity that was higher than the positive control BHT (IC50 value in the range 1.19–2.97 μg/mL). Moreover, all extracts showed iron-reducing activity, with a potency similar to that of BHT (53.01–64.90 vs 3.26 μM Fe(II)/g). The PF extract exhibited a promising lipase inhibitory effect (IC50 value of 29.61 μg/mL).

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“…The dichlorofluorescein (DCF) assay was performed to quantify ROS generation, following the protocol of Manna et al [ 54 ]. The PMNs were treated with P. ferulacea essential oils at a concentration of 25, 50, 100 µg/mL with or without OZ (0.5 mg/mL), following the protocol of Napolitano et al [ 55 ].…”

Section: Methodsmentioning

confidence: 99%

Chemical Composition and Biological Activities of Prangos ferulacea Essential Oils

et al. 2022

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Prangos ferulacea (L.) Lindl, which belongs to the Apiaceae family, is a species that mainly grows in the eastern Mediterranean region and in western Asia. It has been largely used in traditional medicine in several countries and it has been shown to possess several interesting biological properties. With the aim to provide new insights into the phytochemistry and pharmacology of this species, the essential oils of flowers and leaves from a local accession that grows in Sicily (Italy) and has not yet been previously studied were investigated. The chemical composition of both oils, obtained by hydrodistillation from the leaves and flowers, was evaluated by GC-MS. This analysis allowed us to identify a new chemotype, characterized by a large amount of (Z)-β-ocimene. Furthermore, these essential oils have been tested for their possible antimicrobial and antioxidant activity. P. ferulacea essential oils exhibit moderate antimicrobial activity; in particular, the flower essential oil is harmful at low and wide spectrum concentrations. They also exhibit good antioxidant activity in vitro and in particular, it has been shown that the essential oils of the flowers and leaves of P. ferulacea caused a decrease in ROS and an increase in the activity of superoxide dismutase (SOD), catalase (CAT) and glutathione S-transferase (GST) in OZ-stimulated PMNs. Therefore, these essential oils could be considered as promising candidates for pharmaceutical and nutraceutical preparations.

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The chemical composition of the aerial parts of Stachys spreitzenhoferi (Lamiaceae) growing in Kythira Island (Greece), and their antioxidant, antimicrobial, and antiproliferative properties

Cited by 23 publications

References 82 publications

Antimicrobial, Antibiofilm, and Antioxidant Properties of Essential Oil of Foeniculum vulgare Mill. Leaves

Antimicrobial, Antibiofilm, and Antioxidant Properties of Essential Oil of Foeniculum vulgare Mill. Leaves

A New Bloody Pulp Selection of Myrobalan (Prunus cerasifera L.): Pomological Traits, Chemical Composition, and Nutraceutical Properties

Chemical Composition and Biological Activities of Prangos ferulacea Essential Oils

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