The chemical speciation of aluminium in human serum

Size Fractionation of Metal Species from Serum Samples for Studying Element Biodistribution in Alzheimer’s Disease

“…On the other hand, the analysis of the supernatant obtained after protein precipitation of serum samples also showed the existence of low molecular weight carriers for some of these elements in the bloodstream. The percentage of aluminum and cobalt in these LMM species is around 10%, while the concentration of major trace elements iron, copper, and zinc are below 1% in this fraction, in agreement with previous studies [72,[95][96][97][98]. However, other metals could be exclusively detected in the form of metalloproteins, such as cadmium, chromium, manganese, molybdenum, and vanadium.…”

Speciation of Al in human serum by convective-interaction media fast-monolithic chromatography with inductively coupled plasma mass spectrometric detection

“…Due to this, speciation of Al in human serum has been intensively investigated. For determination of the proportion of high molecular mass (HMM) and low molecular mass (LMM) Al species and for the identification of their composition various analytical techniques have been used [12,13]. By applying ultrafiltration and microultrafiltration the percentage of Al bound to HMM and LMM species [14][15][16][17] was estimated.…”

Protein Side Chains Facilitate Mg/Al Exchange in Model Protein Binding Sites

“…As a consequence, both the interaction of aluminum with several biological species that might play a role in its toxic behavior [1][2][3] and substitution of other metals [4,5] have become subjects of close scrutiny. Conformational changes in proteins induced by aluminum that result in alteration of its properties and enhancement of toxic processes have been documented.…”