The Chemistry and Physiology of Abscisic Acid

Milborrow, B. V.

doi:10.1146/annurev.pp.25.060174.001355

Cited by 456 publications

(171 citation statements)

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“…Additionally, a direct polar contact is found between the amine group of Lys59 and the carboxylate group, which is buried into the ABA binding pocket, away from the loops flanking the entry. These data are in agreement with the requirement of the carboxylate group for ABA bioactivity [3], and indeed, different mutations in these residues, e.g. Glu94Lys, Glu141Lys, Lys59Gln, abolish or reduce PYR1 function.…”

Section: Aba-binding Pocketsupporting

confidence: 88%

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Structural insights into PYR/PYL/RCAR ABA receptors and PP2Cs

et al. 2012

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Abscisic acid (ABA) plays an essential function in plant physiology since it is required for biotic and abiotic stress responses as well as control of plant growth and development. A new family of soluble ABA receptors, named PYR/PYL/RCAR, has emerged as ABA sensors able to inhibit the activity of specific protein phosphatases type-2C (PP2Cs) in an ABAdependent manner. The structural and functional mechanism by which ABA is perceived by these receptors and consequently leads to inhibition of the PP2Cs has been recently elucidated. The module PYR/PYL/RCAR-ABA-PP2C offers an elegant and unprecedented mechanism to control phosphorylation signaling cascades in a ligand-dependent manner. The knowledge of their three-dimensional structures paves the way to the design of ABA agonists able to modulate the plant stress response.

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Section: Aba-binding Pocketsupporting

confidence: 88%

“…Consequently, the nonnatural (-)enantiomer only differs structurally in these positions from the (+)enantiomer (Fig. 1B) [3].…”

Section: Introductionmentioning

confidence: 99%

Structural insights into PYR/PYL/RCAR ABA receptors and PP2Cs

et al. 2012

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“…The change in asymmetry to (-)-ABA had a dramatic effect on metabolism but not one of total inhibition. The effect of ABA asymmetry on hormonal activity is more difficult to establish and is currently disputed (11,17,19 (24). The presence of 6'-hydroxymethyl-ABA as an intermediate is supported by results obtained with the cell-free system.…”

Section: Resultsmentioning

confidence: 96%

Abscisic Acid Metabolism by a Cell-free Preparation from Echinocystis lobata Liquid Endoserum

Gillard

Walton²

1976

Plant Physiol.

105

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The in vivo feeding of 2-'4C-ABA to embryonic bean axes (Phaseolus vulgaris L.) has established PA2 and DPA as products in one ABA metabolic pathway (21,23). The accumulation of DPA in bean seeds (24), as well as the continuous formation of PA and DPA in water-stressed leaves (5), indicates that this pathway has an active role in regulating total ABA concentration within the plant. The decreased activity of PA in bioassay systems for growth inhibition (9, 22), abscission promotion (1, 4), and stomatal closure (7) suggests that the DPA pathway has a role in regulating the hormonal activity of ABA. The recent observation that PA inhibits photosynthesis, while ABA does not, indicates that the DPA pathway may also play a role in the activation of physiological activities (7). The actual role which the DPA pathway plays in regulating ABA levels requires the investigation of the enzymes involved. The goal of the present investigation was to establish a cell-free enzyme system capable of metabolizing ABA by the DPA pathway.

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“…Many investigations on the structureactivity relationship in the analogs of abscisic acid (ABA) (1) have been reported,!) and analogs of (2Z)-a-ionylideneacetic acid having the same skeleton as ABA possessed strong growth inhibitory activities.…”

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confidence: 99%