The chemistry of alkyl thiosulfate esters. 8. (E,Z)-Ajoene: a potent antithrombotic agent from garlic

Block, Eric; Ahmad, Saleem; Jain, Mahendra Kumar; Crecely, Roger W.; Apitz‐Castro, Rafael; Cruz, M. R.

doi:10.1021/ja00338a049

Cited by 236 publications

(85 citation statements)

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“…Preparation: eat fresh leaves and cloves, or dried cloves. Active constituents: alliin, essential oil, vitamins A, C, minerals [28], phosphorus, sulfur [29], alliin, allicin, garlic oil [57]- [60].…”

Section: Allium Sativummentioning

confidence: 99%

Key Plants in Fighting Cancer in the Middle East

Rabia¹

2015

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This article is derived from a broader study of ethno-botany, medical anthropology and alternative medicine in Middle Eastern countries, which has been conducted during the past two decades. It presents examples of different edible and medicinal plants and their uses by different communities (urban, peasant and Bedouin) in the treatment of diseases and various medical disorders. Alongside, the article reviews current knowledge concerning plants and cancer prevention and treatment. The article shows that people of these countries use various parts of the plant in a host of manners-fresh and soft, cooked or dried, as both food and medicine. These plants-part of the natural fauna of the Middle Eastern countries-grow in the wild and are cultivated. The author found that the most significant plants used were in the following families: Compositae, Gramineae, Labiatae, Lamiaceae, Liliaceae, Malvaceae, Oleaceae, Ranunculaceae, Umbelliferae, and Urticaceae.

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Section: Allium Sativummentioning

confidence: 99%

Key Plants in Fighting Cancer in the Middle East

Rabia¹

2015

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“…For example, the medicinally active organosulfur compounds of garlic and onions are currently being investigated and evaluated as potentially useful cardiovascular agents (35,36; also see chapter by Lawson, this volume), and ellagic acid, p-carotene, and vitamin E (tocopherols) are being tested and evaluated for their possible utility as prototype anti-mutagenic and cancer-preventing agents (26; also see chapter by Pezzuto, this volume).…”

Section: The Role Of Plant-derived Natural Products In Modern Medicinementioning

confidence: 99%

Plant-Derived Natural Products in Drug Discovery and Development

Balandrin

Kinghorn

Farnsworth

1993

ACS Symposium Series

148

103

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The natural world once served as the source of all medicinal agents, with higher plants constituting by far the principal sources of these. Today, higher plants continue to retain their historical significance as important sources of novel compounds useful directly as medicinal agents, as model compounds for synthetic or semisynthetic structure modifications and optimization, as biochemical and/or pharmacological probes, and as sources of inspiration for generations of synthetic organic medicinal chemists. Plant-derived compounds which have recently undergone development include the anticancer agents, taxol and camptothecin, the Chinese antimalarial drug, artemisinin, and the East Indian Ayurvedic drug, forskolin. These and many other examples serve to illustrate the continuing value of plant-derived secondary metabolites as viable compounds for modern drug development.Higher plants have served humankind as sources of medicinal agents since its earliest beginnings. In fact, natural products once served as the source of all drugs. Today, natural products (and their derivatives and analogs) still represent over 50% of all drugs in clinical use, with higher plant-derived natural products representing ca. 25% of the total. On numerous occasions, the folklore records of many different cultures have provided leads to plants with useful medicinal properties (1-11). In the past two centuries, the chemical investigation and purification of extracts of plants purported to have medicinal properties, and those used as toxins and hunting poisons in their native habitats, have yielded numerous purified compounds which have

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“…4,5) Ajoene was shown by Block et al 6) in 1984 to be an inhibitor of platelet aggregation, and its various biological activities have been well studied. Ajoene has exhibited antibiotic, 7) hepatoprotective, 8) anti-tumor, 9) and anti-diabetic effects.…”

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confidence: 99%

“…Z-Ajoene, at a purity level of >98%, was used in the subsequent experiments; being respectively prepared and its purity determined by using the methods described by Block et al 6) and Lawson et al 12) OMGE containing 1500 mg/g of ajoene was prepared according to the method reported by Hibi,13) with some modifications. HPLC performed for the analysis included the use of a pump (LC-10AS), UV-VIS detector (SPD-10AV), and column oven (CTO-10A) manufactured by Shimadzu Co. (Kyoto, Japan).…”

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confidence: 99%