The chemistry of fungi. Part XXIII. Tumulosic acid

Cort, L. A.; Gascoigne, R. M.; Holker, J. S. E.; Ralph, B. J.; Robertson, Alexander; Simes, J. J. H.

doi:10.1039/jr9540003713

Cited by 25 publications

(13 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The UV spectrum of 1 showed maximum absorption at max 243 nm (log " 4.0), similar to that of ganoderiol A (2), a metabolite previously isolated from the fungus Ganoderma lucidum (Reishi) (Sato, Nishitoba, Shirasu, Oda, & Sakamura, 1986), indicating the presence of a heteroannular diene system in its molecule (Cort et al, 1954). Furthermore, the 1 H and 13 C NMR spectra showed signals due to the conjugated diene group ( H 5.52 and 5.49; C 146.4 C, 117.1 CH, 143.2 C and 120.6 CH), which is suggestive of the 7,9 (11)-diene type of lanostane skeleton and a carboxylic acid group ( 181.3 C).…”

Section: Resultsmentioning

confidence: 90%

Sexangulic acid, a new cytotoxic triterpenoid from the Chinese mangrove Bruguiera sexangula

Huang

Wang

et al. 2010

Natural Product Research

View full text Add to dashboard Cite

show abstract

Section: Resultsmentioning

confidence: 90%

Sexangulic acid, a new cytotoxic triterpenoid from the Chinese mangrove Bruguiera sexangula

Huang

Wang

et al. 2010

Natural Product Research

View full text Add to dashboard Cite

show abstract

“…It has been isolated from a varietyoffungi: Fomes officinalis, Lentinus dactyloides, Polyporus anthracophilus, P. hispidus, P. sulphureus and Poria cocos (KARIYONE and KURONO, 1940;GASCOIGNE et al, 1951;CORT et al, 1954). The acetate has been isolated from P. anthracophilus grown on Eucalyptus regnans wood (GASCOIGNE et at., 1951).…”

Section: Eburlcoic Acidmentioning

confidence: 97%

Biosynthesis

1967

View full text Add to dashboard Cite

All rights, especially that of translation into f oreign 1anguages, reserved. It is also forbidden to reproduce this book, either who1e or in part, by photomechanical means (photostat, microfilm and/or microcard) or by other procedure without written pennission from Springcr-Vcrlag Berlin Heide1bCig GmbH. DedicationFor most areas of scientific pursuit, there is usually that rare investigator who has the imagination to conceive ideas, who has faith in his visions, and who has the ability to critically test his concepts in the laboratory. Almost invariably, this scientist also inspires younger men to enthusiastically enter into his research program. To him should go the accolades and the recognitions of the esteem in which he is held. As only a small part of this esteem, we wish to dedicate these books to Professor SELMAN A. W AKSMAN in appreciation of his leadership and contributions in all facets of antibiotic research. PrefaceThe idea for publishing these books on the mechanism of action and on the biosynthesis of antibiotics was born of frustration in our attempts to keep abreast of the literature. Gone were the years when we were able to keep a bibliography on antibiotics and feel confident that we could find everything that was being published on this sUbject. These fields of investigation were moving forward so rapidly and were encompassing so wide a range of specialized areas in microbiology and chemistry that it was almost impossible to keep abreast of developments. In our naivete and enthusiasm, however, we were unaware that we were toying with an idea that might enmesh us, that we were creating an entity with a life of its own, that we were letting loose a Golom who instead of being our servant would be our master.That we set up ideals for these books is obvious; they would be current guides to developments and information in the areas of mechanism of action and biosynthesis of antibiotics. For almost every subject, we wished to enlist the aid of an investigator who himself had played a part in determining the nature of the phenomena that were being discussed. One concept for the books was that they include only antibiotics for which a definitive, well-documented mechanism of action or biosynthetic pathway was known. Yet, such an approach would not entirely serve the purpose we projected, for it would not encompass all of the information available in these fields of antibiotic investigations and blind searches for the original literature would still have to be made. We therefore chose to include any and all antibiotics about which some pertinent information had been published. It was obvious even at the start that such a compilation, integration, and analysis of information could never be complete unless scientific investigations ceased at the moment the last manuscript was submitted-an end that was neither desirable nor possible. An addendum was therefore included at the end of the volume and left open for the addition of new information until the last pages of the regular articles had been printed.The...

show abstract

“…The data were consistent with those reported in the literature. [24][25][26] D-galactopyranose (D-gal) and Amyloid b-Peptide Fragment 25-35 (Ab [25][26][27][28][29][30][31][32][33][34][35] ) were supplied by Sigma (Company Inc, USA). Distilled water prepared with demineralized water was employed throughout the experiment.…”

Section: Chemicals and Materialsmentioning

confidence: 99%

“…The AD model in rats was induced by D-gal and Ab [25][26][27][28][29][30][31][32][33][34][35] , according to precious reports. [27] Briefly, the rats in AD and normal model groups were given intraperitoneal injection of D-gal (50 mg/kg/day) and the same volume of saline for 6 weeks, respectively; then the AD rats were individually injected with 4 mg Ab [25][26][27][28][29][30][31][32][33][34][35] (1 mg/ml) into each bilateral hippocampu at the co-ordinates antero-posterior, À3.5, mediolateral, +2.0, dorso-ventral, 2.8 mm according to the stereotaxic atlas on the fourth week by brain stereotaxic apparatu. After 6 weeks, all rats were trained to find a visible platform in Morris water maze testing.…”

Section: Animalsmentioning

confidence: 99%

“…T max of GRb1 with a significant difference (p < 0.05) indicates that the rapid absorption in model rats may ascribe to the activity of anti-neuro-inflammation. [30] The neuro-inflammation pathways may be activated in AD rats due to the injection of Ab [25][26][27][28][29][30][31][32][33][34][35] to hippocampus. [27,31] GRb1 could resist these neuroinflammation molecules, resulting in a better absorption in model rats.…”

Section: Pharmacokineticsmentioning

confidence: 99%

See 1 more Smart Citation

A UFLC‐MS/MS method with a switching ionization mode for simultaneous quantitation of polygalaxanthone III, four ginsenosides and tumulosic acid in rat plasma: application to a comparative pharmacokinetic study in normal and Alzheimer's disease rats

Zhang

Sui

et al. 2013

J. Mass. Spectrom.

View full text Add to dashboard Cite

A fast, sensitive and reliable ultra fast liquid chromatography-tandem mass spectrometry (UFLC-MS/MS) method has been developed and validated for simultaneous quantitation of polygalaxanthone III (POL), ginsenoside Rb1 (GRb1), ginsenoside Rd (GRd), ginsenoside Re (GRe), ginsenoside Rg1 (GRg1) and tumulosic acid (TUM) in rat plasma after oral administration of Kai-Xin-San, which plays an important role for the treatment of Alzheimer's disease (AD). The plasma samples were extracted by liquid-liquid extraction using ethyl acetate-isopropanol (1:1, v/v) with salidrdoside as internal standard (IS). Good chromatographic separation was achieved using gradient elution with the mobile phase consisting of methanol and 0.01% acetic acid in water. The tandem mass spectrometric detection was performed in multiple reaction monitoring mode on 4000Q UFLC-MS/MS system with turbo ion spray source in a negative and positive switching ionization mode. The lower limits of quantification were 0.2-1.5 ng/ml for all the analytes. Both intra-day and inter-day precision and accuracy of analytes were well within acceptance criteria (±15%). The mean absolute extraction recoveries of analytes and IS from rat plasma were all more than 60.0%. The validated method has been successfully applied to comparing pharmacokinetic profiles of analytes in normal and AD rat plasma. The results indicated that no significant differences in pharmacokinetic parameters of GRe, GRg1 and TUM were observed between the two groups, while the absorption of POL and GRd in AD group were significantly higher than those in normal group; moreover, the GRb1 absorbed more rapidly in model group. The different characters of pharmacokinetics might be caused by pharmacological effects of the analytes.

show abstract

The chemistry of fungi. Part XXIII. Tumulosic acid

Abstract: A mixture of acids, isolated from artificially grown Polyfiorus tzrwulosus Cooke, P. australiensis Wakefield, or Poria COGOS Wolf, difficult to separate, has been shown to contain a doubly unsaturated dihydroxy-monobasic acid,

Cited by 25 publications

References 0 publications

Sexangulic acid, a new cytotoxic triterpenoid from the Chinese mangrove Bruguiera sexangula

Sexangulic acid, a new cytotoxic triterpenoid from the Chinese mangrove Bruguiera sexangula

Biosynthesis

A UFLC‐MS/MS method with a switching ionization mode for simultaneous quantitation of polygalaxanthone III, four ginsenosides and tumulosic acid in rat plasma: application to a comparative pharmacokinetic study in normal and Alzheimer's disease rats

Contact Info

Product

Resources

About