The Chemistry of HNO: Mechanisms and Reaction Kinetics

Michalski, Radosław; Smulik-Izydorczyk, Renata; Pięta, Jakub; Rola, Monika; Artelska, Angelika; Pierzchała, Karolina; Zielonka, Jacek; Kalyanaraman, Balaraman; Sikora, Adam

doi:10.3389/fchem.2022.930657

Cited by 14 publications

(3 citation statements)

References 147 publications

(299 reference statements)

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“…9 would be unstable and could eliminate hyponitrous acid and disulfide. [45,92] Hyponitrous acid, HONNOH decomposes to N 2 and N 2 O, the gaseous products they observe. [93] Furthermore, Nagasawa and coworkers studied the anaerobic reaction of human serum albumin (HSA), a thiol-containing protein, and other biological thiols such as glutathione and dithiothreitol (DTT) at pH 7.4 and 37 °C with large excess (> 10 times) of NO * .…”

Section: Reaction Of No * With Thiolsmentioning

confidence: 99%

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Update on Endogenous HNO Production: An Exploration of Unanswered Questions and Challenges

Vargas,

Doctorovich,

Suarez

2024

Eur J Inorg Chem

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This review consolidates the evidence supporting endogenous HNO generation through enzymatic and non‐enzymatic pathways, emphasizing advancements in real‐time HNO sensing within living systems. Azanone (nitroxyl, HNO) is the one‐electron‐reduced congener of nitric oxide (NO•) and shares various biological actions. HNO exhibits unique properties, including positive inotropic and lusitropic effects, along with resistance to scavenging by reactive oxygen species (ROS), particularly superoxide. Research on HNO has intensified over the last two decades, focusing on its reactivity and the prospect of endogenous formation due to its potential significance. The high reactivity of HNO arises from reactions with biologically relevant species such as oxygen, NO•, and thiols, as well as self‐dimerization. Detecting and quantifying HNO has posed challenges, initially relying on nitrous oxide (N2O) detection, a byproduct of dimerization. Recent advancements, including fluorescent probes and a specific electrochemical nanomolar‐level sensor, have facilitated direct detection, enhancing understanding of HNO reactivity and formation.

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Section: Reaction Of No * With Thiolsmentioning

confidence: 99%

“…The dihydroxyhydrazine produced in Eq. 9 would be unstable and could eliminate hyponitrous acid and disulfide [45,92] . Hyponitrous acid, HONNOH decomposes to N 2 and N 2 O, the gaseous products they observe [93] …”

Section: Endogenous Hno Generation Pathwaysmentioning

confidence: 99%

Update on Endogenous HNO Production: An Exploration of Unanswered Questions and Challenges

Vargas,

Doctorovich,

Suarez

2024

Eur J Inorg Chem

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“…Nitroxyl (HNO) arises from the protonation of NO following one-electron reduction [ 16 ], as shown in the Figure 1 . It has been shown to act as a regulator of cardiovascular function and has been investigated as a potential treatment for heart failure, myocardial infarction, and hypertension, among other cardiovascular conditions [ 17 ] and hyperalgesia [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

The Therapeutic Potential of Angeli’s Salt in Mitigating Acute Trypanosoma cruzi Infection in Mice

Hideko Tatakihara,

Malvezi,

Pereira

et al. 2023

Pathogens

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Chagas disease (CD), caused by Trypanosoma cruzi, is a neglected tropical disease prevalent in Latin America. Infected patients are treated to eliminate the parasite, reduce the cardiomyopathy risk, and interrupt the disease transmission cycle. The World Health Organization recognizes benznidazole (BZ) and nifurtimox as effective drugs for CD treatment. In the chronic phase, both drugs have low cure rates and serious side effects. T. cruzi infection causes intense tissue inflammation that controls parasite proliferation and CD evolution. Compounds that liberate nitric oxide (NO) (NO donors) have been used as anti-T. cruzi therapeutics. Currently, there is no evidence that nitroxyl (HNO) affects T. cruzi infection outcomes. This study investigated the effects of the HNO donor Angeli’s salt (AS) on C57BL/6 mice infected with T. cruzi (Y strain, 5 × 103 trypomastigotes, intraperitoneally). AS reduced the number of parasites in the bloodstream and heart nests and increased the protective antioxidant capacity of erythrocytes in infected animals, reducing disease severity. Furthermore, in vitro experiments showed that AS treatment reduced parasite uptake and trypomastigote release by macrophages. Taken together, these findings from the murine model and in vitro testing suggest that AS could be a promising therapy for CD.

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Kinetics and Mechanistic Studies of Forskolin Oxidation by Hexavalent Chromium, N-halosuccinimides, Ceric Ammonium Nitrate

Bibballi

2024

Chemistry Africa

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The Chemistry of HNO: Mechanisms and Reaction Kinetics

Cited by 14 publications

References 147 publications

Update on Endogenous HNO Production: An Exploration of Unanswered Questions and Challenges

Update on Endogenous HNO Production: An Exploration of Unanswered Questions and Challenges

The Therapeutic Potential of Angeli’s Salt in Mitigating Acute Trypanosoma cruzi Infection in Mice

Kinetics and Mechanistic Studies of Forskolin Oxidation by Hexavalent Chromium, N-halosuccinimides, Ceric Ammonium Nitrate

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