Fortschritte Der Chemie Organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products / Progrès Dans La Chimi 1958
DOI: 10.1007/978-3-7091-7162-2_3
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The Chemistry of Podophyllum

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Cited by 35 publications
(52 citation statements)
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“…PPT and deoxypodophyllotoxin (99.9% purity), and PPT-4,6-Obenzylidene-␤-D-glucopyranoside (AS 3738) were kind gifts from Kurt Leander (Analytecon SA, Pre Jorat, Switzerland). PPP and DPPP (Ͼ99.7% purity) were prepared from the former two lignans, respectively, by incubation with sodium acetate in aqueous ethanol (23,24) followed by recrystallization or high-performance liquid chromatography (no starting material was then detected in the product, i.e., Ͻ0.1%). For experimental purposes, the cyclolignans were dissolved in physiological saline (5 M), ethanol (0.5 mM), or DMSO (0.5 mM) before addition to cell cultures or cell-free solutions.…”
Section: Methodsmentioning
confidence: 99%
“…PPT and deoxypodophyllotoxin (99.9% purity), and PPT-4,6-Obenzylidene-␤-D-glucopyranoside (AS 3738) were kind gifts from Kurt Leander (Analytecon SA, Pre Jorat, Switzerland). PPP and DPPP (Ͼ99.7% purity) were prepared from the former two lignans, respectively, by incubation with sodium acetate in aqueous ethanol (23,24) followed by recrystallization or high-performance liquid chromatography (no starting material was then detected in the product, i.e., Ͻ0.1%). For experimental purposes, the cyclolignans were dissolved in physiological saline (5 M), ethanol (0.5 mM), or DMSO (0.5 mM) before addition to cell cultures or cell-free solutions.…”
Section: Methodsmentioning
confidence: 99%
“…It is especially effective against the venereal warts caused by Condyloma acuminatum and is offi cially approved for prescription use for this purpose under the name podofi lox (Condylox ® , DPT Labs, San Antonio, TX) (Hartwell and Schrecker 1958;Mack 1992;Bonnez et al 1994;Ferenczy 1995). It is especially effective against the venereal warts caused by Condyloma acuminatum and is offi cially approved for prescription use for this purpose under the name podofi lox (Condylox ® , DPT Labs, San Antonio, TX) (Hartwell and Schrecker 1958;Mack 1992;Bonnez et al 1994;Ferenczy 1995).…”
Section: Distribution and Habitat-species Of Podophyllummentioning
confidence: 99%
“…Podophyllotoxin (PPT, 1) is a naturally occurring lactone extracted from Podophyllum peltatum and/or Podophyllum emodi plant (Berberidaceae) [1,2]. It is a potent spindle poison that blocks mitosis by effecting microtubule assembly which are crucial for cell division.…”
Section: Introductionmentioning
confidence: 99%