The chemistry of the carbon–transition metal double and triple bond: Annual survey covering the year 2009

Recent Advances in the Synthesis of Thiophene Derivatives by Cyclization of Functionalized Alkynes

“…Metal-catalyzed heterocyclization of functionalized alkynes bearing a suitably placed heteronucleophilic group is a powerful methodology for the regioselective and atom-economical synthesis of substituted heterocycles starting from readily available acyclic substrates (Scheme 1, Y = heteroatom) [31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49]. The generally accepted mechanism for this important transformation involves the electrophilic activation of the triple bond by coordination to the metal center, followed by either exo or endo cyclization (ensuing from intramolecular nucleophilic attack by the –YH group to the coordinated triple bond) and protonolysis (Scheme 1).…”

A Recyclable Palladium-Catalyzed Synthesis of 2-Methylene-2,3-Dihydrobenzofuran-3-ols by Cycloisomerization of 2-(1-Hydroxyprop-2-ynyl)phenols in Ionic Liquids

“…Metal-catalyzed heterocyclization reactions are a powerful methodology for the direct synthesis of substituted heterocyclic derivatives starting from readily available substrates [1,2,3,4,5,6,7,8,9,10,11]. The process occurs through the activation of an unsaturated bond by coordination to the metal center, followed by endo or exo intramolecular attack by the nucleophilic group (YH) and protonolysis or vice versa (Scheme 1—the case of a functionalized alkyne is shown).…”

Development of a Method for the Preparation of Ruthenium Indenylidene-Ether Olefin Metathesis Catalysts

“…Metal alkylidene complexes have been the focus of intense research in synthetic chemistry [ 1 ]. Most notable are the Schrock molybdenum and tungsten alkylidene [ 2 ] and the Grubbs ruthenium alkylidene complexes [ 3 ], which are excellent catalysts for olefin metathesis and have enabled an astonishingly broad spectrum of applications in organic and polymer synthesis [ 4 ].…”