The Chemistry of the Phthalazines.

Vaughan, Wyman R.

doi:10.1021/cr60136a003

Cited by 60 publications

(14 citation statements)

References 102 publications

(186 reference statements)

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“…Phthalazine derivatives, that have two bridgehead nitrogen atoms in a fused ring system, have attracted considerable attention because of their pharmacological and biological properties, potential clinical application [75][76][77][78][79][80][81][82][83] and promising luminescent and fluorescent probes. [84] The synthesis of 1H-indazolo[1,2-b]phthalazine-1,6,11-trione derivatives have been achieved by Kidwai and colleagues via a convenient one-pot protocol using phthalhydrazide, cyclic-β-diketone and aldehydes catalyzed by CAN (5 mol%) in polyethylene glycol (PEG) at ambient temperature (Scheme 19).…”

Section: Synthesis Of 1h-indazolo[12-b]phthalazine-1611-trionesmentioning

confidence: 99%

Ceric Ammonium Nitrate (CAN)–Catalyzed Multicomponent Reactions: An Efficient Catalyst for Green Organic Synthesis

Prajapati

Vekariya

Patel

2015

Synthetic Communications

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The multicomponent reactions (MCRs) consist of two or more synthetic steps which are carried out without isolation of any intermediate thus reducing time, saving money, energy and raw materials. The development of MCRs in the presence of Ceric Ammonium Nitrate (CAN) is an efficient approach that meets with the requirements of sustainable chemistry. The aim of this review is to highlight the interactive effect of the combined use of MCRs and CAN for the development of new eco-favourable methodologies for synthetic organic chemistry. Many advantages for the use of CAN as a catalyst in organic synthesis, such as, a very small amount of this catalyst is enough to complete the reactions in most cases, lower costs, eco-friendly nature, ease of handling, non-toxicity, high reactivity.

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Section: Synthesis Of 1h-indazolo[12-b]phthalazine-1611-trionesmentioning

confidence: 99%

Ceric Ammonium Nitrate (CAN)–Catalyzed Multicomponent Reactions: An Efficient Catalyst for Green Organic Synthesis

Prajapati

Vekariya

Patel

2015

Synthetic Communications

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“…The intense green chemiluminescence observed during the oxidation of "lucigenin" (6) with HzO2 in alkaline solution was first described by Gleu and Petsch [36] (cf. [7]).…”

Section: 9'-diacridinium Salts ("Lucigenin" and Related Compounds)mentioning

confidence: 99%

“…Since the first publication [48] describing the intense blue chemiluminescence accompanying the alkaline oxidation of 3-aminophthalhydrazide (5-amino-l,2,3,4-tetrahydrophthalazine-1,4-dione) ( I I ) , these and similar chemiluminescence reactions have been studied in great detail [2][3][4][5][6]46,48]. The reader is referred in particular to Anderson's review [7], which presents an excellent analysis of the position regarding the luminol problem at the beginning of the second phase of these investigations (after 1945).…”

Section: -Aminophthalhydrazide ("Luminol") and Other Hydrazidesmentioning

confidence: 99%

Chemiluminescence in Organic Compounds

Gundermann

1965

Angew. Chem. Int. Ed. Engl.

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Dedicated to Professor Fritz Micheel on the occasion of his 65th birthday As a result of the development of very sensitive equipment, it is now possible to show that the chemiluminescence of organic compounds in solution is quite a common phenomenon. Notable advances have been made during recent years in the investigation of the chemiluminescence of substituted phthalic acid hydrazides and related compounds. A new and probably generally applicable method of producing chemiluminescence has recently been discovered in the reaction of aromatic free-radical anions with appropriate free-radical cations.

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“…Among a large variety of heterocyclic compounds, nitrogencontaining heterocycles are widespread and their applications in biologically active pharmaceuticals, agrochemicals, and functional materials are becoming more and more important [2][3][4][5][6]. Among a large variety of nitrogen-containing heterocyclic compounds, heterocycles containing bridgehead hydrazine have received considerable attention because of their pharmacological properties and clinical applications [7][8][9][10][11][12][13][14][15][16]. One such group of heterocyles are phthalazine derivatives, they were reported to possess cardiotonic [17], vasorelaxan [18], cytotoxic [19], antimicrobial [20], antifungal [21], anticancer [22], anti-inflammatory [23] and anticonvulsant [24] activities.…”

Section: Introductionmentioning

confidence: 99%