The chemoattraction of lymphocytes by rheumatoid arthritis - synovial fluid is not dependent on the chemokine receptor CCR5

Santiago, Begoña; Galindo, María; Rivero, Miguel; Mt, Brehmer; Mateo, Isabel; Pablos, JL

doi:10.1007/s00296-002-0203-1

Cited by 7 publications

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

CCR5 is involved in resolution of inflammation in proteoglycan‐induced arthritis

Doodes¹,

Cao²,

Hamel³

et al. 2009

Arthritis & Rheumatism

View full text Add to dashboard Cite

Objective. CCR5 and its ligands (CCL3, CCL4, and CCL5) may play a role in inflammatory cell recruitment into the joint. However, it was recently reported that CCR5 on T cells and neutrophils acts as a decoy receptor for CCL3 and CCL5 to assist in the resolution of inflammation. The aim of this study was to determine whether CCR5 functions as a proinflammatory or antiinflammatory mediator in arthritis, by examining the role of CCR5 in proteoglycan (PG)-induced arthritis (PGIA). Methods. Arthritis was induced by immunizing wild-type (WT) and CCR5-deficient (CCR5؊/؊ ) BALB/c mice with human PG in adjuvant. The onset and severity of PGIA were monitored over time. Met-RANTES was used to block CCR5 in vivo. Arthritis was transferred to SCID mice, using spleen cells from arthritic WT and CCR5 ؊/؊ mice. The expression of cytokines and chemokines was measured by enzymelinked immunosorbent assay.Results. In CCR5 ؊/؊ mice and WT mice treated with the CCR5 inhibitor Met-RANTES, exacerbated arthritis developed late in the disease course. The increase in arthritis severity in CCR5 ؊/؊ mice correlated with elevated serum levels of CCL5. However, exacerbated arthritis was not intrinsic to the CCR5 ؊/؊ lymphoid cells, because the arthritis that developed in SCID mouse recipients was similar to that in WT and CCR5 ؊/؊ mice. CCR5 expression in the SCID mouse was sufficient to clear CCL5, because serum levels of CCL5 were the same in SCID mouse recipients receiving cells from either WT or CCR5 ؊/؊ mice. Conclusion. These data demonstrate that CCR5 is a key player in controlling the resolution of inflammation in experimental arthritis.

show abstract

CCR5 is involved in resolution of inflammation in proteoglycan‐induced arthritis

Doodes¹,

Cao²,

Hamel³

et al. 2009

Arthritis & Rheumatism

View full text Add to dashboard Cite

show abstract

The Chemokine System and Arthritis

et al.

View full text Add to dashboard Cite

Rheumatoid arthritis (RA) affects 1% of the U.S. population, or 3 million people. RA is a chronic infl ammatory disease characterized by synovial infl ammation and hyperplasia, neovascularization, and progressive destruction of cartilage and bone. The cause(s) of RA remains poorly defi ned, but it is thought that both genetic and environmental factors, including molecular mimicry and host responses against cross-reactive antigens, lead to the development of autoimmune responses involving the joints. The goal of this chapter is to provide an overview of the contribution of members of the chemokine system to the immunopathogenesis of RA. This is of high clinical relevance because of the burgeoning interest in the use of chemokine and chemokine-receptor blockers in the treatment of a variety of infl ammatory, autoimmune, and infectious disorders, including RA.

show abstract

The complex role of the chemokine receptor CCR2 in collagen-induced arthritis: implications for therapeutic targeting of CCR2 in rheumatoid arthritis

et al. 2005

View full text Add to dashboard Cite

CCR2 has been widely considered as a potential therapeutic target for autoimmune disease, particularly rheumatoid arthritis, and various CCR2 blocking agents have been developed, some of which have entered clinical trials. In this review, we examine the relevant information regarding the role of CCR2, and to a lesser extent of the closely related chemokine receptor CCR5, in the immunopathogenesis of collagen-induced arthritis, an animal model of rheumatoid arthritis. Experimental evidence showing that CIA is accelerated and exacerbated when CCR2 is genetically inactivated (knockout mice) or blocked with specific antibodies warrant additional investigations before the relevance of the findings in rodent models can be applied to human patients with RA.

show abstract

The chemoattraction of lymphocytes by rheumatoid arthritis - synovial fluid is not dependent on the chemokine receptor CCR5

Cited by 7 publications

References 35 publications

CCR5 is involved in resolution of inflammation in proteoglycan‐induced arthritis

CCR5 is involved in resolution of inflammation in proteoglycan‐induced arthritis

The Chemokine System and Arthritis

The complex role of the chemokine receptor CCR2 in collagen-induced arthritis: implications for therapeutic targeting of CCR2 in rheumatoid arthritis

Contact Info

Product

Resources

About