The chemokine SDF-1/CXCL12 modulates the firing pattern of vasopressin neurons and counteracts induced vasopressin release through CXCR4

Callewaere, Céline; Banisadr, Ghazal; Desarménien, Michel G.; Mechighel, Patricia; Kitabgi, Patrick; Rostène, William; Parsadaniantz, Stéphane Melik

doi:10.1073/pnas.0602620103

Cited by 77 publications

(76 citation statements)

References 34 publications

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“…These data suggest that chemokines may represent a new class of neuromodulatory peptides that may be involved notably in the autocrine neuroendocrine control of AVP neurons ( Fig. 4; Callewaere et al 2006).…”

Section: Acute Stimulationmentioning

confidence: 99%

“…By means of dual fluorescent immunohistochemistry (Banisadr et al 2003, Callewaere et al 2006, we first demonstrated the co-localization of SDF-1/CXCL12 and its receptor CXCR4 with AVP neurons in the magnocellular neurons of the SON and PVN hypothalamic nuclei and on AVP projections in the median eminence (Fig. 1) to the neurohypophysis (Callewaere et al 2006). Electrophysiological recordings of SON neurons clearly demonstrate that SDF-1/CXCL12 through its receptor CXCR4 affects the electrical activity of AVP neurons.…”

Section: Chemokines and Water Balancementioning

confidence: 99%

“…Moreover, in another recent report, we investigated a possible neuroendocrine role of another chemokine: SDF-1/CXCL12. By means of dual fluorescent immunohistochemistry (Banisadr et al 2003, Callewaere et al 2006, we first demonstrated the co-localization of SDF-1/CXCL12 and its receptor CXCR4 with AVP neurons in the magnocellular neurons of the SON and PVN hypothalamic nuclei and on AVP projections in the median eminence (Fig. 1) to the neurohypophysis (Callewaere et al 2006).…”

Section: Chemokines and Water Balancementioning

confidence: 99%

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Chemokines and chemokine receptors in the brain: implication in neuroendocrine regulation

Callewaere

Banisadr²,

Rostène³

et al. 2007

Journal of Molecular Endocrinology

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Chemokines are small secreted proteins that chemoattract and activate immune and non-immune cells both in vivo and in vitro. In addition to their well-established role in the immune system, several recent reports have suggested that chemokines and their receptors may also play a role in the central nervous system (CNS). The best known central action is their ability to act as immuno-inflammatory mediators. Indeed, these proteins regulate leukocyte infiltration in the brain during inflammatory and infectious diseases. However, we and others recently demonstrated that they are expressed not only in neuroinflammatory conditions, but also constitutively by different cell types including neurons in the normal brain, suggesting that they may act as modulators of neuronal functions. The goal of this review is to highlight the role of chemokines in the control of neuroendocrine functions. First, we will focus on the expression of chemokines and their receptors in the CNS, with the main spotlight on the neuronal expression in the hypothalamo-pituitary system. Secondly, we will discuss the role -we can now suspect -of chemokines and their receptors in the regulation of neuroendocrine functions. In conclusion, we propose that chemokines can be added to the well-described neuroendocrine regulatory mechanisms, providing an additional fine modulatory tuning system in physiological conditions.

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Section: Acute Stimulationmentioning

confidence: 99%

Section: Chemokines and Water Balancementioning

confidence: 99%

Section: Chemokines and Water Balancementioning

confidence: 99%

See 1 more Smart Citation

Chemokines and chemokine receptors in the brain: implication in neuroendocrine regulation

Callewaere

Banisadr²,

Rostène³

et al. 2007

Journal of Molecular Endocrinology

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“…SDF-1a modulates the activity of vasopressinergic neurons recorded in the rat supraoptic and paraventricular nucleus slices through CXCR4, resulting in changes in the AVP release (Callewaere et al 2006). SDF-1a can blunt the autoregulation of AVP release in vitro and counteract angiotensin II-induced plasma AVP release in vivo.…”

Section: Effects On Neuronal Activity and Neurotransmitter Releasementioning

confidence: 99%

Multiple actions of the chemokine stromal cell-derived factor-1α on neuronal activity

Guyon¹,

Nahon²

2007

Journal of Molecular Endocrinology

118

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The chemokine SDF-1a and its cognate receptor CXCR4 are expressed in several neuronal populations. This review focuses on our current knowledge about the actions of this chemokine on neuronal excitability, through CXCR4 or other yet unknown pathways. In various neuronal populations (CA1 neurons of the hippocampus, granular and Purkinje cells of the cerebellum, melanin-concentrating hormone neurons of the lateral hypothalamus, vasopressinergic neurons of the supraoptic and the paraventricular nucleus of the hypothalamus, and dopaminergic neurons of the substantia nigra), SDF-1a can modulate the activity of neurons by multiple regulatory pathways including and often combining: (i) modulation of voltage-dependent channels (sodium, potassium, and calcium), (ii) activation of the G-protein-activated inward rectifier potassium current, and (iii) increase in neurotransmitter release (gamma-amino butyric acid (GABA), glutamate, and dopamine), often through Ca-dependent mechanisms. The possible mechanisms underlying these effects and their consequences in terms of modulation of neuroendocrine systems and physiopathology are discussed.

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“…By blocking CXCR4, antagonist human Immunodeficiency virus (HIV)-1 gp120 inhibits the long-term potentiation (LTP) in the CA1 region of rat hippocampus through indirect release of gamma-aminobutyric acid type A (GABAA) while no effects were observed on basal synaptic transmission (Dong J and Xiong H, 2006). CXCL12 affects the electrical activity of arginine vasopressin (AVP) neurons, resulting in changes in AVP release (Callewaere C et al, 2006). Chemokines and gp120 have been suggested to facilitate pain pathways via direct actions on chemokine receptors expressed by nociceptive neurons (Oh SB et al, 2001).…”

Section: Neuromodulationmentioning

confidence: 99%

Multiple roles of chemokine CXCL12 in the central nervous system: A migration from immunology to neurobiology

Ransohoff

2008

Progress in Neurobiology

307

245

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Chemotactic cytokines (chemokines) have been traditionally defined as small (10-14 kDa) secreted leukocyte chemoattractants. However, chemokines and their cognate receptors are constitutively expressed in the central nervous system (CNS) where immune activities are under stringent control. Why and how the CNS uses the chemokine system to carry out its complex physiological functions has intrigued neurobiologists. Here, we focus on chemokine CXCL12 and its receptor CXCR4 that have been widely characterized in peripheral tissues and delineate their main functions in the CNS. Extensive evidence supports CXCL12 as a key regulator for early development of the CNS. CXCR4 signaling is required for the migration of neuronal precursors, axon guidance/pathfinding and maintenance of neural progenitor cells (NPCs). In the mature CNS, CXCL12 modulates neurotransmission, neurotoxicity and neuroglial interactions. Thus, chemokines represent an inherent system that helps establish and maintain CNS homeostasis. In addition, growing evidence implicates altered expression of CXCL12 and CXCR4 in the pathogenesis of CNS disorders such as HIVassociated encephalopathy, brain tumor, stroke and multiple sclerosis (MS), making them the plausible targets for future pharmacological intervention.

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The chemokine SDF-1/CXCL12 modulates the firing pattern of vasopressin neurons and counteracts induced vasopressin release through CXCR4

Cited by 77 publications

References 34 publications

Chemokines and chemokine receptors in the brain: implication in neuroendocrine regulation

Chemokines and chemokine receptors in the brain: implication in neuroendocrine regulation

Multiple actions of the chemokine stromal cell-derived factor-1α on neuronal activity

Multiple roles of chemokine CXCL12 in the central nervous system: A migration from immunology to neurobiology

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