1994
DOI: 10.1016/0020-7519(94)90163-5
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The chemosensitivity of the rodent malarias — relationships with the biology of merozoite

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Cited by 21 publications
(9 citation statements)
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“…However in the published examples of protection against wild-type blood-stage P. berghei by subunit vaccination, the challenge strain was P. berghei NK65 rather than ANKA303132. P. berghei NK65 infection results in a greater number of ‘latent merozoites' than ANKA, meaning merozoites are in the blood for longer (and thus potentially more accessible to antibody) before invading a new RBC57. NK65 is also known to i) have a greater predilection to invade immature RBC (reticulocytes); ii) be more likely to multiply infect the same cell; and iii) produce more ring forms early in infection43, leading to a less synchronous infection than the ANKA strain.…”
Section: Discussionmentioning
confidence: 99%
“…However in the published examples of protection against wild-type blood-stage P. berghei by subunit vaccination, the challenge strain was P. berghei NK65 rather than ANKA303132. P. berghei NK65 infection results in a greater number of ‘latent merozoites' than ANKA, meaning merozoites are in the blood for longer (and thus potentially more accessible to antibody) before invading a new RBC57. NK65 is also known to i) have a greater predilection to invade immature RBC (reticulocytes); ii) be more likely to multiply infect the same cell; and iii) produce more ring forms early in infection43, leading to a less synchronous infection than the ANKA strain.…”
Section: Discussionmentioning
confidence: 99%
“…Based on previous reports (9,11,13) and a pilot study (data not shown), CQ doses of 0, 300, 600, 900, and 1,500 g CQ (approximately 0, 10, 20, 30, and 50 mg/kg, respectively, for a 30-g mouse) were selected for the dose ranging studies. The CQ solutions were administered to each mouse by i.p.…”
Section: Maymentioning
confidence: 99%
“…chabaudi -, or P. vinckei -infected mice. The two latter murine strains differ from the former by their marked preference for invading mature erythrocytes and their high degrees of synchronization [27-28]. Most of the tested compounds were able to clear parasitemia, which is evidence of their antimalarial potencies.…”
Section: Bis(quaternary Ammonium) Derivatives: Pharmacophore Establismentioning
confidence: 99%