The Chesson Strain of Plasmodium Vivax Malaria: II. Relationship between Prepatent Period, Latent Period and Relapse Rate

The Therapeutic Effectiveness of Large Doses of Paludrine in Acute Attacks of Sporozoite-Induced Viv Ax Malaria (Chesson Strain) 1

“…The five subjects who failed to relapse after treatment with paludrine or quinine had infections of only moderate intensity (11).…”

“…It is possible under the conditions of these investigations to differentiate between subjects with severe infections and those with moderate infections, on the basis of the length of the prepatent period or the preceding parasitic latent period. In subjects with short preceding prepatent or latent periods the relapse rate of Chesson infections was 98 per cent after treatment with suppressive drugs, whereas when these periods were long, the relapse rate was only 67 per cent (11).…”

“…The Chesson strain was chosen because it is characterized by a high relapse rate, a short latent interval between relapses, and a low incidence of delayed primary attacks (9,10,11). This strain has been used extensively in testing new antimalarial agents.…”

The Use of Sn-10,275 in the Prophylaxis and Treatment of Sporozoite-Induced Viv Ax Malaria (Chesson Strain) 1

“…In the therapeutic tests, SN-10,275 was administered to two individuals whose attacks belonged to the first group and, therefore, constituted a severe therapeutic 4 The observations reported in this paper would not have been possible except for the enthusiastic cooperation of the inmates and administrative officers at Stateville Penitentiary.…”

“…It is a compound of the Ainley-King series, which has a high degree of antimalarial activity in cathemerium and lophurae malaria in the duck and moderate activity in gallinaceum and lophurae malaria in the chick ( 1 ). PROCEDURES Caucasian volunteers 4 at Stateville Penitentiary were infected with Southwest Pacific vivax malaria (Chesson strain) (3) by the bites of infected Anopheles quadrimaculatus mosquitoes. This strain is characterized by a high relapse rate when treated with non-curative drugs such as quinine and quinacrine (atabrine), by a short period of latency between successive attacks, and by almost complete absence of delayed primary attacks.…”