SUMMARY In routine reporting of electrocardiograms, a frequent problem is presented by the presence of repolarisation abnormalities (ST depression and/or T wave inversion) in the lateral leads without the accepted QRS voltage criterion of left ventricular hypertrophy.To help resolve this problem, the electrocardiograms of 41 patients with severe aortic stenosis who had no evidence of coronary disease were compared with the electrocardiograms of 20 patients with lateral myocardial infarction who had no clinical evidence of left ventricular hypertrophy. Nine of the patients with aortic stenosis were found to show repolarisation abnormalities in the lateral leads without the standard voltage criterion of left ventricular hypertrophy. The repolarisation pattern of aortic stenosis could frequently be distinguished from that of coronary disease by the presence of one or more of the following five features: depression of the J point, asymmetry of the T wave with rapid return to the baseline, terminal positivity of the T wave ("over-shoot"), T inversion in V6 greater than 3 mm, and T inversion greater in V6 than in V4.One of the most common problems of an electrocardiogram reporting service is knowing how to interpret repolarisation abnormalities (ST depression and/or T wave inversion) confined to the lateral leads. ' If the QRS voltage is abnormally great, the tracing is likely to be reported as indicating left ventricular hypertrophy; otherwise it will probably be reported as suggestive of ischaemia.We set out to answer two questions. First, may repolarisation abnormalities in the lateral leads without abnormal RS voltage be a result of left ventricular hypertrophy? Secondly, can such abnormalities be differentiated from those seen in coronary arterial disease?
Subjects and methodsIn essence, our method was to take a group of patients with severe aortic stenosis without significant coronary arterial disease and compare their electrocardiograms with those of a group of patients with lateral myocardial infarction without clinical evidence of left ventricular hypertrophy.
LEFT VENTRICULAR HYPERTROPHY GROUPThis group consisted of 41 adult patients with aortic stenosis on whom haemodynamic studies (including in 39 cases coronary arteriography) were performed as part of an assessment for aortic valve replacement.Received for publication 26 March 1981 ST depression or T inversion in the lateral leads and excluded. None of these patients gave a history of previous myocardial infarction and none was receiving digoxin or any similar drug. Their ages ranged from 26 to 69 years, with a mean of 54 years. Twenty-one were men and 20 were women. The aortic valve gradients ranged from 45 to 170 mmHg, with a mean of 90 mmHg. Two patients, one woman aged 26 and one man aged 35, were not submitted to coronary arteriography. Of the 39 patients in whom coronary arteriography was performed, the arteriogram was entirely normal in 26; and in the remaining 13 there was less than 50% narrowing of a single coronary artery branch. The aetiolog...