The present review aims to discuss the importance of a multidisciplinary approach in cultural heritage and archaeometry investigations. The analytical methods used to identify and characterize “Green Stones” are discussed as an example. In the present paper, the term Green Stones is applied but not limited to jade materials, which have considerable importance in cultural heritage studies. In fact, archaeological samples made in Green Stones have been discovered worldwide, with many dating back to the Neolithic Age. Moreover, these materials represent an interesting analytical challenge, starting with their nomenclature and, in most cases, the nature of their polycrystalline samples and their heterogeneity. Indeed, after a brief introduction about the advantages of the non-destructive analytical techniques commonly used for gemstones and cultural heritage samples analyses, the limits of the same have been discussed on the basis of Green Stones applicability. Finally, a multidisciplinary methodology for Green Stones identification and full characterization, which considers materials’ heterogeneity and information, has been proposed and based on different references.