The chicken or the egg? Does glycaemic control predict cognitive function or the other way around?

Ganmore, Ithamar; Beeri, Michal Schnaider

doi:10.1007/s00125-018-4689-9

Cited by 11 publications

(7 citation statements)

References 37 publications

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“…However, it is not clear whether patients' irrational choices are the cause or the effect of poor glycemic control and subsequent diabetic complications. There is a similar controversy regarding cognitive function and type 2 diabetes mellitus; 18,19 cognitive function appears to be an important factor for patients' irrational responses, as discussed below.…”

Section: Discussionmentioning

confidence: 99%

<p>Irrational Responses to Risk Preference Questionnaires by Patients with Diabetes with or without Retinopathy and Comparison with Those without Diabetes</p>

Emoto

Soga

Izumi

et al. 2020

DMSO

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Purpose The risk preferences of patients with diabetes have profound effects on the progression of complications. The present study aimed to clarify whether the preferences of patients with diabetes and retinopathy are deliberately risk-seeking or irrational and whether this propensity is specific to those with retinopathy or is also found in patients without retinopathy compared with those without diabetes. Patients and Methods A total of 394 patients with diabetes (264 without retinopathy and 130 with retinopathy) and 198 patients without diabetes agreed to participate in this survey. The questions were modified versions of those from the Japan Household Survey on Consumer Preferences and Satisfaction, which sought to determine the participants’ personal socioeconomic status and risk preferences. In the questionnaires, responses were analyzed by determining the participants’ willingness to pay for a lottery ticket and for an insurance policy. Irrational responses were defined as violations of two axioms of the Expected Utility Theory: completeness and transitivity. Results The incidence of irrational responses increased with age and was associated with educational level. The incidence of irrational responses was significantly higher in patients with retinopathy than in those without retinopathy after adjusting for age and educational level. There was no significant difference in the incidence of irrational responses between patients with diabetes but without retinopathy and those without diabetes. Conclusion The risk-seeking behavior of patients with diabetes and retinopathy was not deliberate but was irrational under uncertainty. Medical professionals should be aware of their patients’ propensity to make irrational decisions, which is an important risk factor for the progression of retinopathy in patients with diabetes regardless of age and educational level.

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Section: Discussionmentioning

confidence: 99%

<p>Irrational Responses to Risk Preference Questionnaires by Patients with Diabetes with or without Retinopathy and Comparison with Those without Diabetes</p>

Emoto

Soga

Izumi

et al. 2020

DMSO

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“…Cognitive deficits in T2DM are most commonly related to memory and executive function, which may also lead to problems with T2DM self‐management and hence with activities essential to glycaemic control (Gatlin & Gatlin & Insel, ). So far, most studies of cognitive function and T2DM have focused on the risk of developing dementia or on how existing impairments increase the risk for worse glycaemic control (Ganmore & Beeri, ; Rapp et al, ). Recently, more attention has been paid to how cognitive impairments affect T2DM self‐management (Marseglia et al, ).…”

Section: Introductionmentioning

confidence: 99%

Targeting cognitive function: Development of a cognitive training intervention for diabetes

Cuevas

Stuifbergen

Brown

2020

Int J of Nursing Practice

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Aim: The aim of this project was to develop and demonstrate the feasibility of a comprehensive cognitive training intervention to build self-efficacy for implementation of cognitive strategies in people with diabetes. Background: People with diabetes are at greater risk than the general population for developing cognitive dysfunction. Some attention has been paid to the effect of cognitive impairments on diabetes self-management, but even when cognitive problems have been identified, few interventions have been tailored for those with diabetes. Methods: The intervention combines in-person classes and home-based online computer training. Development, in 2017, included (a) adaptation of prior established, tested interventions; (b) interviews with stakeholders; and (c) integration of course content. Results: Information provided by the stakeholders was used to modify an existing intervention to meet the needs of people with diabetes so that feasibility testing could occur. Despite initial difficulty with recruitment, the intervention was found to be feasible, and nineteen participants found it to be acceptable. Conclusion: This comprehensive cognitive training intervention targeting type 2 diabetes and cognitive dysfunction demonstrates that existing interventions can be adapted for use with people with diabetes.

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“…In addition, the vagus nerve has a complex connection with the visceral central hippocampus [10]. Epidemiological studies indicate that disrupted glucose and lipid metabolism frequently occurs in Alzheimer's disease (AD) [11]. Similarly, animal studies have shown elevated glucose and lipid levels in rats with cognitive impairment [12].…”

Section: Introductionmentioning

confidence: 99%

Effect of hepatic sympathetic nerve removal on energy metabolism in an animal model of cognitive impairment and its relationship to Glut2 expression

et al. 2020

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AbstractThe aims of this study were to investigate the effect of hepatic sympathetic nerve removal on glucose and lipid metabolism in rats with cognitive impairment and to evaluate the relationship between these effects and liver Glut2 expression. Hippocampal injection of Aβ1–42 was used to induce cognitive impairment. Impaired rats were divided into experimental, sham, and control groups. The experimental group was injected with 6-hydroxydopamine to remove the sympathetic nerve. At 4 weeks post injection, body weight, food and water intake, blood sugar, and blood lipids were measured, and periodic acid-Schiff (PAS) staining was used to assess the liver glycogen content. Liver Glut2 mRNA and protein were also detected. The experimental group showed reduced body weight, food intake, and blood glucose levels and elevated insulin levels compared with the control group. PAS staining showed higher glycogen contents in the experimental group than in controls. The expression levels of Glut2 mRNA and protein in the experimental group were significantly lower than in the controls. Metabolism was significantly impacted in rats with cognitive impairment following removal of the hepatic sympathetic nerve. Disruption to Glut2 liver expression via sympathetic nerve disruption represents a possible underlying mechanism.

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The chicken or the egg? Does glycaemic control predict cognitive function or the other way around?

Cited by 11 publications

References 37 publications

<p>Irrational Responses to Risk Preference Questionnaires by Patients with Diabetes with or without Retinopathy and Comparison with Those without Diabetes</p>

<p>Irrational Responses to Risk Preference Questionnaires by Patients with Diabetes with or without Retinopathy and Comparison with Those without Diabetes</p>

Targeting cognitive function: Development of a cognitive training intervention for diabetes

Effect of hepatic sympathetic nerve removal on energy metabolism in an animal model of cognitive impairment and its relationship to Glut2 expression

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