The Childhood Asthma Control Test∗: Retrospective determination and clinical validation of a cut point to identify children with very poorly controlled asthma

Liu, Andrew H.; Zeiger, Robert S.; Sorkness, Christine A.; Ostrom, Nancy K.; Chipps, Bradley E.; Rosa, Kathleen; Watson, Melanie; Kaplan, Max; Meurer, John R.; Mahr, Todd A.; Blaiss, Michael S.; Piault-Louis, Elisabeth; McDonald, Jeffrey G.

doi:10.1016/j.jaci.2010.05.031

Cited by 104 publications

(111 citation statements)

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“…The selected cut-off was <19 (sensitivity of 70%, specificity of 88%) [28]. Quality of life was measured using the self-administered version of the Paediatric Asthma Quality of Life Questionnaire (PAQLQ ) [29].…”

Section: Methodsmentioning

confidence: 99%

Role of Periostin in Uncontrolled Asthma in Children (DADO study)

Mena

Abejón

Vidigal

et al. 2017

J Investig Allergol Clin Immunol

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Background: Asthma is the most common chronic disease in children. Cases of severe asthma (SA) are underdiagnosed. Periostin is a biomarker for SA in adults, but its role in children is poorly understood. Objectives: The aims of the study were to estimate the percentage of cases of uncontrolled severe asthma (UcSA) in children with poorly controlled asthma and to evaluate the role of periostin as a biomarker. Materials and Methods: We performed an observational study in children aged 5 to 14 years with poorly controlled asthma. Demographic and clinical data were collected in addition to the results of the lung function test, the fraction of exhaled nitric oxide, the skin prick test, total IgE, specific IgE, blood eosinophil count, serum periostin, treatment, asthma control, and quality of life. Variables were compared between the group with UcSA and the other children. Results: Fifty children with poorly controlled asthma (72% male) were included. Nineteen children (38%) had UcSA. Most children had limitations in their activities of daily living and had visited the emergency department. In addition, 38% were hospitalized. Quality of life was poor. Only 42% of the children received appropriate treatment. The UcSA group was more likely to have a total IgE >500 kU A /mL (52.6% vs 19%, P=.02) and less likely to have serum periostin >1000 ng/mL (31.2% vs 63%, P=.04). Conclusions: In our setting, 38% of children with poorly controlled asthma have UcSA, which is associated with higher levels of total serum IgE and lower levels of serum periostin.

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Section: Methodsmentioning

confidence: 99%

Role of Periostin in Uncontrolled Asthma in Children (DADO study)

Mena

Abejón

Vidigal

et al. 2017

J Investig Allergol Clin Immunol

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“…[18][19][20] For children, the cACT has more validation data than other tools that target children with asthma. [37][38][39] Also, the populations used in the validation studies vary between tools. For instance, in the United States, studies have included mostly white patients.…”

Section: Discussionmentioning

confidence: 99%

“…[37][38][39][40] In the developmental study, Liu et al 36 reported that the cACT overall score discriminated between patients who differ in the specialists' rating of asthma control. Similarly, Chen et al 37 reported that mean cACT scores were significantly lower among patients with poor asthma control as compared with those who were well controlled according to specialists' rating.…”

Section: Validitymentioning

confidence: 99%

“…Liu et al 38 found that 66% of children who were classified as having "very poorly controlled" asthma according to NAEPP EPR-3 guidelines scored 12 or less on the cACT. Those children had a lower mean percent-of-predicted FEV 1 , had more frequent prescriptions to step-up therapy, and were more frequently rated as having severe asthma compared with those who scored 13-19.…”

Section: Accuracymentioning

confidence: 99%

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Asthma Control Assessment Tools

Alzahrani

Becker

2015

Respir Care

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, and they emphasize periodic assessment of asthma control once treatment is established. Accurate assessment of asthma control is difficult due to the complexity of asthma control and due to the limitations in the traditional methods of assessment, such as lung function tests, physician assessment, and patients' self-assessment. Relying solely on the role of lung function tests is insufficient to reflect the status of asthma control, since patients with asthma may have normal spirometry between exacerbations. Clinicians often overestimate the level of asthma control. Similarly, it is not uncommon for patients to overestimate how well their asthma is controlled, and, therefore, they under-report asthma symptoms and fail to recognize the impact that asthma has on their daily life. As a result, several tools have been developed to quantify the level of asthma control, identify patients at risk, and evaluate the effect of asthma management. This review examines the commonly 106RESPIRATORY CARE • JANUARY 2016 VOL 61 NO 1 used asthma control assessment tools in terms of content, psychometric properties, methods of administration, limitations, and ability to reflect the overall status of asthma control, which can aid clinicians in selecting the most appropriate tool for their needs.

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“…Each question offers several answers, which are scored on a scale from 0 to 5. Patients are classified into one of 3 groups on the basis of their C-ACT score: very poorly controlled (score of:S 2), not well controlled (score of [13][14][15][16][17][18][19] or well controlled (score~20) (8).…”

Section: Patients With Asthmamentioning

confidence: 99%

Anesthesia in Children with Asthma and Rhinitis

Franceschini

Benedictis

Peroni

et al. 2011

Int J Immunopathol Pharmacol

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The incidence of asthma is increasing worldwide, but morbidity and mortality are decreasing, because of improvements in medical care. Although the incidence of severe perioperative bronchospasm is relatively low in asthmatics undergoing anaesthesia, when it does occur it may be life-threatening. Preoperative assessment of asthma should include a specialized medical hystory and physical examination as well as pulmonary function testing. Potential trigger agents should be identified and avoided. In many asthmatic patients treatment with systemic corticosteroids and bronchodilators is indicated to prevent the inflammation and bronchocostriction associated with endotracheal intubation. Nonetheless, acute bronchospasm can still occur, especially at induction and emergence, and should be promptly and methodically managed.

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The Childhood Asthma Control Test∗: Retrospective determination and clinical validation of a cut point to identify children with very poorly controlled asthma

Cited by 104 publications

References 4 publications

Role of Periostin in Uncontrolled Asthma in Children (DADO study)

Role of Periostin in Uncontrolled Asthma in Children (DADO study)

Asthma Control Assessment Tools

Anesthesia in Children with Asthma and Rhinitis

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