The chimera of S1 and N proteins of SARS-CoV-2: can it be a potential vaccine candidate for COVID-19?

Kumar, Amresh; Ladha, Amit; Choudhury, Ankita; Ikbal, Abu Md Ashif; Bhattacharjee, Bedanta; Das, Tarun; Gupta, Gaurav; Sharma, Chhavi; Sarbajna, Adity; Mandal, Subhash C.; Choudhury, Manabendra Dutta; Ali, Nahid; Sláma, Petr; Rezaei, Nima; Palit, Partha; Tiwari, Onkar Nath

doi:10.1080/14760584.2022.2081156

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Enhancement Strategy For Antigen Detection1

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“…30 SARS-CoV-2 N protein is involved in various cellular processes, such as viral outgrowth, RNA replication, and mRNA transcription. 31 Both S and N proteins are immunogenic and abundantly expressed during viral assembly. 32 However, it has been shown that testing for the N antigen yields better detection sensitivity than the S antigen, 33 and thus most of the current antigen tests are performed based on the N antigen.…”

Section: Enhancement Strategy For Antigen Detectionmentioning

confidence: 99%