The Chinese Anti-Inflammatory and Immunosuppressive Herbal Remedy Tripterygium Wilfordii Hook F

Tao, Xiaochun; Lipsky, Peter E.

doi:10.1016/s0889-857x(05)70118-6

Cited by 271 publications

(195 citation statements)

References 15 publications

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“…Hutch., and T. forrestii Loes., from China; and T. doianum Ohwi, also from Japan. T. regelii, T. hypoglaucum (known in Chinese as kunmiminshanhaitang (Xia et al, 1994), shan hai ton, san hai ton, or zi jin pi), and T. forrestii have also been used in TCM (Tao and Lipsky, 2000). Some authors consider these to be varieties of T. wilfordii rather than separate species, and the most recent taxonomic treatment of the genus reduced all other species to synonymy with T. wilfordii .…”

Section: Taxonomy Of the Genus Tripterygiummentioning

confidence: 99%

“…In China this plant, known as lei kung teng or lei gong teng ("Thunder God Vine"), has a long history of use in traditional Chinese Medicine (TCM) for treating swelling, fever, chills, sores, joint pain, and inflammation (Tao et al, 1991;Li, 1993). Preparations of Tripterygium began to be used in allopathic medicine in China in the 1960s to treat rheumatoid arthritis (RA) and inflammation (Tao and Lipsky, 2000). Since then they have also been used for cancer, chronic nephritis, hepatitis, systemic lupus erythematosus, ankylosing spondylitis, and a variety of skin conditions (Juling et al, 1981;Qin et al, 1981;Xu et al, 1985;Takaishi et al, 1992a;Li, 1993).…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, the efficacy of these extracts in disease treatment may be greater than that of triptolide (1) alone, due to additive or even synergistic effects between different compounds in the extracts, for example with tripdiolide (31). This review summarizes the pharmacology of Tripterygium extracts, a topic discussed in more detail elsewhere (Tao and Lipsky, 2000;Qiu and Kao, 2003;Ho and Lai, 2004), and discusses related activities exhibited by other compounds found in this genus.…”

Section: Introductionmentioning

confidence: 99%

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Medicinal chemistry and pharmacology of genus Tripterygium (Celastraceae)

et al. 2007

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Plants in the genus Tripterygium, such as Tripterygium wilfordii Hook. f., have a long history of use in traditional Chinese medicine. In recent years there has been considerable interest in the use of Tripterygium extracts and of the main bioactive constituent, the diterpene triepoxide triptolide (1), to treat a variety of autoimmune and inflammation-related conditions. The main mode of action of the Tripterygium extracts and triptolide (1) is the inhibition of expression of proinflammatory genes such as those for interleukin-2 (IL-2), inducible nitric oxide synthase (iNOS), tumor necrosis factor-α (TNF-α), cyclooxygenase-2 (COX-2) and interferon-gamma (IFN-γ). The efficacy and safety of certain types of Tripterygium extracts were confirmed in human clinical trials in the US and abroad. Over 300 compounds have been identified in the genus Tripterygium, and many of these have been evaluated for biological activity. The overall activity of the extract is based on the interaction between its components. Therefore, the safety and efficacy of the extract cannot be fully mimicked by any individual constituent. This review discusses the biochemical composition and biological and pharmacological activities of Tripterygium extracts, and their main bioactive components.

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Section: Taxonomy Of the Genus Tripterygiummentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Medicinal chemistry and pharmacology of genus Tripterygium (Celastraceae)

et al. 2007

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“…It is a perennial vine-like plant that is abundant in south China [9]. Anti-inflammatory and immunosuppressive compounds extracted from TwHF have been used for the treatment of a wide spectrum of autoimmune and inflammatory diseases, including RA [10, 11], ankylosing spondylitis [12, 13], and systemic lupus erythematosus [14].…”

Section: Introductionmentioning

confidence: 99%

Extracts ofTripterygium wilfordiiHook F in the Treatment of Rheumatoid Arthritis: A Systemic Review and Meta-Analysis of Randomised Controlled Trials

Liu

Gao

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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Clinical trials have reported the effects of Tripterygium wilfordii Hook F (TwHF) extracts (TEs) in the treatment of rheumatoid arthritis (RA); however, the results have been inconsistent. This meta-analysis is aimed to assess the safety of TEs and their effects on the treatment of RA. Randomised controlled trials (RCTs) comparing the effects of TEs and placebo (PBO) or disease-modifying antirheumatic drugs (DMARDs) in patients with RA were included. Weighted mean differences (MDs) were calculated for net changes by employing fixed-effect or random-effects models. After filtering, ten RCTs (involving 733 participants) were included in this study. The methodological quality of these studies was generally low. Compared with DMARDs, TEs alone produced a mild increase in grip strength (GS) (P = 0.02; standard mean difference (SMD) = 0.81; 95% confidence interval (CI): 0.14 to 1.48). The most common adverse effects (AEs) of TEs were gastrointestinal discomfort, menstruation disorders, and amenorrhea. In conclusion, TEs, as a sort of “herbal DMARD,” could be as effective as synthetic DMARDs in the treatment of RA. However, the efficacy of TEs in treating RA should be further estimated with better designed, fully powered, confirmatory RCTs that apply the American College of Rheumatology (ACR) improvement criteria to evaluate their outcomes.

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“…Notably, Shima et al showed that glomerular IgA deposits disappeared following combined therapy with corticosteroids and AZA in children with IgAN showing diffuse mesangial proliferation (17). TwHF, an extract from a traditional Chinese medicine, has been widely used to treat autoimmune and inflammatory diseases, including lupus nephritis and rheumatoid arthritis (18–20). A previous study showed that Chinese patients with IgAN benefited from TwHF treatment (21).…”

Section: Discussionmentioning

confidence: 99%

Continuation of immunosuppressive treatment may be necessary in IgA nephropathy patients with remission of proteinuria: Evaluation by repeat renal biopsy

Luo

Yao

et al. 2013

Experimental and Therapeutic Medicine

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The present study aimed to evaluate the effects of an individualized, low-dose multi-drug immunosuppressive regimen for the treatment of immunoglobulin A nephropathy (IgAN). A preliminary investigation of the course of IgAN following immunosuppressive treatment was conducted based on repeat renal biopsies. Clinical and pathological data of 17 patients with IgAN who received repeat renal biopsies were analyzed retrospectively. In addition to basic treatment, 16 patients regularly received an individualized low-dose immunosuppressive regimen according to their clinical manifestations and pathological patterns following the first biopsy. Clinical parameters, including 24-h urinary protein excretion and levels of serum albumin, uric acid and total cholesterol were collected. Glomerular deposits of IgA and C3, as well as the activity and chronicity indexes of renal lesions were evaluated by semi-quantitative methods. The 24-h urinary protein excretion of the patients decreased significantly from the first biopsy (2.53±2.17 g/day) to the repeated biopsy (0.26±0.55 g/day) (P<0.001). Deposits of IgA and C3 in the glomerulus were persistent, but were reduced in quantity at the second biopsy. Although active renal lesions were observed in the majority of patients, the activity index decreased significantly from 3.18±1.33 prior to therapy to 2.47±0.80 following therapy (P<0.05), while the chronicity index did not change significantly (2.59±2.00 versus 2.76±1.89, respectively). The individualized, low-dose multi-drug immunosuppressive regimen used in the present study significantly minimized proteinuria, stabilized renal function and alleviated histological lesions in patients with IgAN without causing overt adverse effects during the short-term follow-up. In addition to proteinuria, renal pathological changes should be appraised when considering the withdrawal of immunosuppressants from IgAN treatment.

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The Chinese Anti-Inflammatory and Immunosuppressive Herbal Remedy Tripterygium Wilfordii Hook F

Cited by 271 publications

References 15 publications

Medicinal chemistry and pharmacology of genus Tripterygium (Celastraceae)

Medicinal chemistry and pharmacology of genus Tripterygium (Celastraceae)

Extracts ofTripterygium wilfordiiHook F in the Treatment of Rheumatoid Arthritis: A Systemic Review and Meta-Analysis of Randomised Controlled Trials

Continuation of immunosuppressive treatment may be necessary in IgA nephropathy patients with remission of proteinuria: Evaluation by repeat renal biopsy

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