1982
DOI: 10.2337/diab.31.1.s14
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The Chinese Hamster as a Model for the Study of Diabetes Mellitus

Abstract: Selection for and against diabetes and subsequent inbreeding of Chinese hamsters started in 1963. Currently there are six inbred sublines that have greater than 85% incidence of glycosuria and two control inbred nondiabetic sublines that are essentially free of glycosuria. At birth, hamsters from inbred sublines are considered prediabetic. There is phenotypic variation between diabetic sublines. Onset time, incidence of ketonuria, blood glucose, plasma insulin, glucagon and glycohydrolase levels vary from subl… Show more

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Cited by 61 publications
(37 citation statements)
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“…We chose a spontaneous diabetic hamster model, in which two sublines of different glycaemic levels have been created through breeding, one with mild and one with severe hyperglycaemia [11]. Previous studies established that the spontaneous diabetic hamster eventually develops some early features of diabetic retinopathy such as acellular capillaries and an increase in the capillary endothelial cell to pericyte ratio [12]. Using retinal digest preparations of animals with various durations of diabetes (3±12 months) we compared animals with mild and severe hyperglycaemia, measured retinal autofluorescent AGE and parameters of diabetic retinopathy such as pericyte loss and acellular capillaries.…”
mentioning
confidence: 99%
“…We chose a spontaneous diabetic hamster model, in which two sublines of different glycaemic levels have been created through breeding, one with mild and one with severe hyperglycaemia [11]. Previous studies established that the spontaneous diabetic hamster eventually develops some early features of diabetic retinopathy such as acellular capillaries and an increase in the capillary endothelial cell to pericyte ratio [12]. Using retinal digest preparations of animals with various durations of diabetes (3±12 months) we compared animals with mild and severe hyperglycaemia, measured retinal autofluorescent AGE and parameters of diabetic retinopathy such as pericyte loss and acellular capillaries.…”
mentioning
confidence: 99%
“…Non-diabetic hamsters of both sexes were taken from the M inbred genetic subline. Definitions, metabolic characteristics and genetic background of prediabetic, diabetic and non-diabetic Chinese hamsters have been described in detail elsewhere [29]. Prediabetic and diabetic animals were age-and sex-matched with the nondiabetic animals.…”
Section: Animalsmentioning
confidence: 99%
“…Due to its potent vasodilator activity [24] and its possible involvement in regulation of relaxation [25][26][27] and contraction [28] of the urogenital tract, it was of interest to determine whether concentration and/or distribution of this peptide are altered in the eye and urinary bladder of a suitable diabetic animal model. Since the spontaneously diabetic Chinese hamster is adequately ics, metabolic characteristics and disorders of the eye and urinary bladder [29], it seemed appropriate to evaluate VIP in this species. Therefore, the purpose of the present study was to determine by radioimmunoassay and immunocytochemistry whether VIP was deranged in the eye and urinary bladder of diabetic and prediabetic XA, AC and AH genetic sublines of Chinese hamsters compared with age-matched non-diabetic M subline animals.…”
mentioning
confidence: 99%
“…The overt diabetes range from mild to severe and it is characterized by polyphagia, hyperglycemia, severe polyuria, glucosuria and elevated gluconeogenesis. ÎČ-cells present degranulation and hydropic degeneration [63][64][65].…”
Section: Long Evans Tokushima Lean (Letl) a N O U T B R E D C O L O mentioning
confidence: 99%