The Chinese Pueraria root extract (Pueraria lobata) ameliorates impaired glucose and lipid metabolism in obese mice

Prasain, Jeevan K.; Peng, Ning; Rajbhandari, Rajani; Wyss, J. Michael

doi:10.1016/j.phymed.2012.09.017

Cited by 69 publications

(59 citation statements)

References 28 publications

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“…The T max of puerarin (approximately 0.5 hours) was much shorter [36] than those of daidzein, genistein, and their glucosides. Prasain et al [9] also hypothesized that the sodium-dependent glucose transporter (SGLT) is involved in the transport system of puerarin in a rat model [31][32][33]. The rapid absorption of puerarin in our study might be attributable to the absorption from the small intestine via SGLT.…”

Section: Biokinetics Of Kudzu Isoflavonessupporting

confidence: 48%

“…A previous report indicated that nonmetabolized puerarin and a small amount of its glucuronide were detected in the serum of rats orally administered puerarin [31]. Moreover, Prasain et al [9] demonstrated that puerarin was widely distributed (kidney, liver, lung, pancreas, heart, eye, and brain) in rats orally administered puerarin [31][32][33]. Hence, almost all puerarin presumably is absorbed from the intestine, enters into the systemic circulation, and is distributed in the tissues without deglycosylation and conjugation.…”

Section: Biokinetics Of Kudzu Isoflavonesmentioning

confidence: 97%

“…Puerariae radix is the dried root of kudzu, often called "kakkon." Prasain et al [9] demonstrated that kudzu root extract ameliorates impaired glucose and lipid metabolism in obese male mice. They also reported that diet containing kudzu root extract significantly lowers not only arterial pressure, but also blood cholesterol, glucose, and insulin levels in stroke-prone spontaneously hypertensive rats [10].…”

Section: Kudzu Vine As a Food Materials Applicable For Metabolic Disormentioning

confidence: 99%

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Aging and unhealthy eating habits increase the risk of metabolic disorders such as obesity, diabetes and osteoporosis. One of the applicable ways to prevent these negative health outcomes is daily utilization of food materials and/or food factors which contains physiologically active and safe compounds. Kudzu (Pueraria lobata) is a creeping and tree-climbing plant with long vines belonging to Leguminosae family. It has been used as a food material over thousand years as well as a medicinal plant in oriental countries. This mini review introduces health-beneficial effects of kudzu vine isoflavones and their biokinetics in ovariectomized (OVX) mice. Dietary kudzu vine extracts and a diet consisting of puerarin, the major isoflavone, improved glucose metabolism, weight gain and osteoporosis independent of the estrogen receptor-mediated pathway in OVX mice. As population ages, health problems associated with age and menopause in women are becoming increasingly notable. The findings in this study suggest that dietary kudzu vine isoflavones and puerarin present a promising approach to prevent life style related diseases like obesity, diabetes and osteoporosis.

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Section: Biokinetics Of Kudzu Isoflavonessupporting

confidence: 48%

Section: Biokinetics Of Kudzu Isoflavonesmentioning

confidence: 97%

Section: Kudzu Vine As a Food Materials Applicable For Metabolic Disormentioning

confidence: 99%

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2017

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“…Dried kudzu roots (Puerariae radix) are traditionally used in Asian countries, including Japan, as an herbal medicine to treat the common cold, headaches, diarrhea, and hypertension. Prasain et al demonstrated that kudzu root extract ameliorated impaired glucose and lipid metabolism in obese male mice (6). They also reported that in addition to lowering arterial blood pressure, a kudzu root extract diet significantly reduced blood cholesterol, glucose, and insulin levels in stroke-prone spontaneously hypertensive rats (7).…”

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confidence: 99%

Anti-Hyperglycemic Effect of a Kudzu (<i>Pueraria lobata</i>) Vine Extract in Ovariectomized Mice

Tanaka

Yukihiro

Tang

et al. 2016

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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Summary Postmenopausal diabetes is exacerbated by estrogen deficiency. Ovariectomized (OVX) animal models can be used to develop strategies for preventing or treating postmenopausal symptoms. We previously found that a diet containing kudzu (Pueraria lobata) vine ethanol extract (PVEE) suppressed weight gain in OVX mice. Therefore, this study further elucidated how PVEE affected OVX mice. Ten-week-old OVX or sham-operated mice were fed diets containing either no PVEE (control) ·d 21 puerarin (daidzein-8-C-glucoside), a major isoflavone present in PVEE, for 10 wk. The effects of puerarin on glucose tolerance were also tested in OVX mice. The experimental diets were not associated with any abnormalities in any mice tested in the present study. Weight gain and serum glucose levels were increased in OVX mice and these effects were significantly attenuated in OVX mice that consumed PVEE (5 or 20 mg·kg 21 ·d 21 ) or puerarin. Puerarin-treated OVX mice also showed reduced serum glucose levels following administration of 1,000 mg·kg 21 glucose. These results suggested that puerarin contributed to PVEE-mediated improvements in glucose metabolism in OVX mice. Although further studies are needed to clarify the molecular mechanism underlying these observations, PVEE and puerarin could provide effective approaches to the amelioration of postmenopausal diabetes. Key Words Kudzu, Pueraria lobata, postmenopausal diabetes, puerarin, glucose metabolism Postmenopausal women have an increased risk for metabolic diseases such as obesity and diabetes (1, 2), which increase their risk of developing other serious conditions including cancers, neurological disorders, hypertension, and other kinds of cardiovascular disease (3). Postmenopausal diabetes is induced by estrogen deficiency, which exacerbates insulin resistance (4, 5). The number of postmenopausal patients with diabetes has recently increased, due to the increasing age of the population. Therefore, dietary strategies to reduce the risk for diabetes are expected to be necessary in order to improve postmenopausal health.Kudzu (Pueraria lobata) is a creeping vine of the Leguminosae family. The plant has spread worldwide and is predominantly found in temperate climates. Dried kudzu roots (Puerariae radix) are traditionally used in Asian countries, including Japan, as an herbal medicine to treat the common cold, headaches, diarrhea, and hypertension. Prasain et al. demonstrated that kudzu root extract ameliorated impaired glucose and lipid metabolism in obese male mice (6). They also reported that in addition to lowering arterial blood pressure, a kudzu root extract diet significantly reduced blood cholesterol, glucose, and insulin levels in stroke-prone spontaneously hypertensive rats (7).Pharmaceutical legislation in Japan classifies the kudzu root as a medicinal resource, rather than a food, and we therefore investigated whether dietary consumption of other parts of the plant had beneficial effects on postmenopausal diabetes. Our previous study of a kudzu vine ethanol extract ...

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“…It has been reported that puerarin improved insulin resistance and glucose tolerance (Prasain et al 2012), protected pancreatic islet from hydrogen peroxide-induced b-cell damage (Xiong et al 2006) and lowered blood glucose level in mice challenged with streptozotocin (STZ) (Hsu et al 2003), via promoting glucose uptake by skeletal muscle and adipocytes (Hsu et al 2003, Lee et al 2010 and attenuating glucose and insulin response (Prasain et al 2012). However, there is a lack of understanding of whether puerarin can act on insulin-producing b-cell and improve its function and survival.…”

Section: Introductionmentioning

confidence: 99%

Puerarin protects pancreatic β-cell survival via PI3K/Akt signaling pathway

Li¹,

Shangguan²,

Liu³

et al. 2014

Journal of Molecular Endocrinology

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Pancreatic b-cell loss because of apoptosis is the major cause of type 1 diabetes (T1D) and late stage T2D. Puerarin possesses anti-diabetic properties; whether it acts directly on pancreatic b-cell is not clear. This study was designed to investigate the effects of puerarin on pancreatic b-cell survival and function. Diabetes was induced in male C57BL/6 mice by a single peritoneal injection of streptozotocin (STZ). Pancreatic b-cell survival and function were assessed in diabetic mice by measuring b-cell apoptosis, b-cell mass, pancreatic insulin content, and glucose tolerance, and in cultured islets and clonial MIN6 b-cells by measuring b-cell viability and apoptosis and glucose-stimulated insulin secretion. We found that pre-treatment with puerarin decreased the incidence of STZ-induced diabetes. Puerarin increased pancreatic b-cell mass via b-cell apoptosis inhibition in diabetic mice, and increased serum insulin, whereas it decreased blood glucose levels and improved glucose tolerance. In cultured islets and MIN6 cells, puerarin protected b-cell from cobalt chloride (CoCl 2 )-induced apoptosis and restored the impaired capacity of glucose-stimulated insulin secretion. Puerarin protection of b-cell survival involved the phosphoinositide 3-kinase (PI3K) /Akt signaling pathway. In conclusion, puerarin protects pancreatic b-cell function and survival via direct effects on b-cells, and its protection of b-cell survival is mediated by the PI3K/Akt pathway. As a safe natural plant extraction, puerarin might serve as a preventive and/or therapeutic approach for diabetes.

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The Chinese Pueraria root extract (Pueraria lobata) ameliorates impaired glucose and lipid metabolism in obese mice

Cited by 69 publications

References 28 publications

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Anti-Hyperglycemic Effect of a Kudzu (<i>Pueraria lobata</i>) Vine Extract in Ovariectomized Mice

Puerarin protects pancreatic β-cell survival via PI3K/Akt signaling pathway

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