The Chinese Version of Oxford Depression Questionnaire: A Validation Study in Patients with Mood Disorders

Zhu, Yueyong; Wu, Lingling; Ye, Shuling; Fu, Yichun; Huang, Huimin; Lai, Jianbo; Shi, Chuan; Hu, Shaohua

doi:10.2147/ndt.s396356

Cited by 2 publications

(3 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The higher the value of ODQ is, the greater the degree of emotional blunting. The Chinese version of the ODQ has been validated to have good reliability [ 21 ].…”

Section: Outcome Measuresmentioning

confidence: 99%

Efficacy of functional magnetic resonance imaging-guided personalized repetitive transcranial magnetic stimulation (fMRI-rTMS) in depressive patients with emotional blunting: study protocol for a randomized controlled trial

Zhang,

Tang,

Lei

et al. 2024

Trials

View full text Add to dashboard Cite

Background Emotional blunting is a symptom that has always been present in depressed patients. Repetitive transcranial magnetic stimulation (rTMS) is a safe and effective supplementary therapy for treating depression. However, the effectiveness and brain imaging processes of functional magnetic resonance imaging-guided personalized rTMS (fMRI-rTMS) in the treatment of depression with emotional blunting have not been observed in randomized controlled trials. Methods This study is a randomized, controlled, double-blind, and single-center clinical trial in which 80 eligible depressed patients with emotional blunting will be randomly assigned to two groups: a functional magnetic resonance imaging-guided personalized rTMS (fMRI-rTMS) group and a control group. Individuals in the fMRI-rTMS group (n = 40) will receive high-frequency rTMS (10 Hz, 120% MT). The main target of stimulation will be the area most relevant to the functional connectivity of the right medial prefrontal cortex (mPFC) and amygdala. The control group (n = 40) will receive sham stimulation, with a coil flipped to 90 degrees relative to the vertical scalp. All patients will receive 15 consecutive days of treatment, with each session lasting half an hour per day, followed by 8 weeks of follow-up. The primary outcome is the comparison of Oxford Depression Questionnaire (ODQ) scores between these two groups at different time points. The secondary outcomes include evaluating other clinical scales and assessing the differences in brain imaging changes between the two groups before and after treatment. Discussion This trial aims to examine the effects of functional magnetic resonance imaging-guided personalized rTMS (fMRI-rTMS) intervention on depressed patients experiencing emotional blunting and to elucidate the potential mechanism behind it. The results will provide new evidence for using fMRI-rTMS in treating depression with emotional blunting in the future. Trial registration ClinicalTrials.gov INCT05555940. Registered on 13 September 2022 at http://clinicaltrials.gov.

show abstract

“…The higher the value of ODQ is, the greater the degree of emotional blunting. The Chinese version of the ODQ has been validated to have good reliability [ 21 ].…”

Section: Outcome Measuresmentioning

confidence: 99%

Efficacy of functional magnetic resonance imaging-guided personalized repetitive transcranial magnetic stimulation (fMRI-rTMS) in depressive patients with emotional blunting: study protocol for a randomized controlled trial

Zhang,

Tang,

Lei

et al. 2024

Trials

View full text Add to dashboard Cite

show abstract

“…17 The Oxford Depression Questionnaire (ODQ) is a patient-reported scale specifically developed for assessing emotional blunting 9 and is increasingly included in studies that want to assess the effect of antidepressant treatment on positive and negative emotions. [18][19][20] It has been validated in English 9 (original version) and Chinese, 19,20 and has been shown to have high acceptability, construct validity, reliability and sensitivity to change. 9,19,20 The ODQ includes 26 items covering the four dimensions of emotional blunting: not caring, emotional detachment, positive reduction, and general reduction.…”

Section: Introductionmentioning

confidence: 99%

“…[18][19][20] It has been validated in English 9 (original version) and Chinese, 19,20 and has been shown to have high acceptability, construct validity, reliability and sensitivity to change. 9,19,20 The ODQ includes 26 items covering the four dimensions of emotional blunting: not caring, emotional detachment, positive reduction, and general reduction. The ODQ is divided into three sections where Section 1 evaluates the patient's experience of emotional blunting during the past week and Section 2 compares the current experience of emotional blunting with the patient's recollection of their normal emotional state before their depression.…”

Section: Introductionmentioning

confidence: 99%

Assessing Reliability and Validity of the Oxford Depression Questionnaire (ODQ) in a Japanese Clinical Population

Kato,

Kikuchi,

Watanabe

et al. 2023

NDT

View full text Add to dashboard Cite

Originally developed in English, the Oxford Depression Questionnaire (ODQ) is a patient-reported scale specifically developed for assessing emotional blunting in people with major depressive disorder (MDD). We aimed to examine the reliability and validity of the Japanese version of the ODQ. Patients and methods: This was a prespecified analysis of a prospective, 24-week, multicenter, observational cohort study of employed Japanese outpatients with MDD initiating treatment with vortioxetine according to the Japanese label (JRCT1031210200). Participants were assessed using the Japanese version of the ODQ and other clinical rating scales at baseline and Weeks 8, 12 and 24. Results: One hundred and sixteen patients initiated vortioxetine and had ≥1 post-baseline visit. Directionally, the associations between ODQ scores and other clinical measures were as expected and demonstrated good concurrent validity. Factor analysis shows that the scale has a good fit for three factors. The Cronbach's α coefficient was 0.912, and the scale also showed good test-retest reliability with intraclass correlation coefficients for the ODQ total score and domains ranging between 0.69 and 0.82. ODQ scores had strong positive correlations with symptom severity assessed using the Montgomery and Åsberg Depression Rating Scale and were moderately correlated with work productivity, overall functioning, and quality of life scales. Conclusion: Data from this prospective analysis confirm that the Japanese version of the ODQ retains the good validity and reliability of the original English scale and is suitable for use in prospective studies wanting to capture treatment effects on emotional blunting in MDD.

show abstract

The Chinese Version of Oxford Depression Questionnaire: A Validation Study in Patients with Mood Disorders

Cited by 2 publications

References 25 publications

Efficacy of functional magnetic resonance imaging-guided personalized repetitive transcranial magnetic stimulation (fMRI-rTMS) in depressive patients with emotional blunting: study protocol for a randomized controlled trial

Efficacy of functional magnetic resonance imaging-guided personalized repetitive transcranial magnetic stimulation (fMRI-rTMS) in depressive patients with emotional blunting: study protocol for a randomized controlled trial

Assessing Reliability and Validity of the Oxford Depression Questionnaire (ODQ) in a Japanese Clinical Population

Contact Info

Product

Resources

About