The Cholegas Study: safety of prophylactic cholecystectomy during gastrectomy for cancer: preliminary results of a multicentric randomized clinical trial

Bernini, Marco; Bencini, Lapo; Sacchetti, Riccardo; Marchet, Alberto; Cristadoro, Luigi; Pacelli, Fabio; Berardi, Stefano; Doglietto, Giovanni Battista; Rosa, Fausto; Verlato, Giuseppe; Cozzaglio, Luca; Bechi, Paolo; Marrelli, Daniele; Roviello, Franco; Farsi, Marco

doi:10.1007/s10120-012-0195-9

Cited by 43 publications

(41 citation statements)

References 28 publications

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“…However, one case (1.5%) of biliary leakage that was probably caused by prophylactic cholecystectomy was observed [10]. Another Japanese study concluded that the addition of laparoscopic cholecystectomy did not alter complications, mortality, and length of stay in patients undergoing laparoscopic gastrectomy for gastric cancer.…”

Section: Discussionmentioning

confidence: 99%

“…This approach also avoided the possibility of subsequent cholecystectomy, which might be difficult owing to potential adhesion at the upper abdomen caused by previous gastrectomy and lymph node dissection [9]. A multicenter, randomized controlled trial, the Cholegas study, was initiated in November 2008 to evaluate prophylactic cholecystectomy; however, the final result has not been disclosed yet [10].…”

Section: Introductionmentioning

confidence: 99%

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Analysis of gallstone disease after gastric cancer surgery

et al. 2017

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Background The incidence rate of newly developed gallstone disease after gastrectomy for gastric cancer is thought to be higher than that in the general population. However, the presentation and management of these gallstones remain under debate, and the role of prophylactic cholecystectomy remains questionable. Methods Data on adult patients who were diagnosed with gastric cancer and received gastrectomy between 2000 and 2011 were extracted from the Taiwan National Health Insurance Research Database. A patient was excluded if he or she had gallstone disease or received cholecystectomy before the index date. The incidence of newly developed gallstone disease and its subsequent management were recorded. Data were analyzed to evaluate the factors associated with gallstone development and treatment options. Results A total of 17,325 gastric cancer patients who underwent gastrectomy were eligible for analysis. During the follow-up period (mean 4.1 years; median, 2.9 years), 1280 (7.4%) patients developed gallstone disease and 560 (3.2%) patients subsequently underwent cholecystectomy. The in-hospital mortality for cholecystectomy was 1.8% (10/560). Development of gallstone disease was associated with older age, total gastrectomy, duodenal exclusion, diabetes, cirrhosis, and more comorbidities. Factors associated with the use of cholecystectomy to treat gallstone disease included younger age, fewer comorbidities, medical center admission, and presentation as cholecystitis. Conclusions Although few patients required further gallbladder removal after gastrectomy for gastric malignancy, the increased mortality rate for subsequent cholecystectomy was worth noting. The decision to undergo prophylactic cholecystectomy might be individualized based upon patient characteristics and the surgeon's discretion.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Analysis of gallstone disease after gastric cancer surgery

et al. 2017

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“…Combined cholecystectomy for asymptomatic gallstone in GC surgery may be considered in young patients; otherwise, it is not clear if cholecystectomy is indicated in patients without gallstones; a recent GIRCG multicenter study showed no difference in medium-term outcome between patients receiving or not receiving prophylactic cholecystectomy [18].…”

Section: Surgical Therapy Resectionmentioning

confidence: 99%