The choline-binding protein PspC of Streptococcus pneumoniae interacts with the C-terminal heparin-binding domain of vitronectin

Abstract

Background: Adhesins are essential for pneumococcal colonization and pathogenesis. Results: PspC, identified as a vitronectin-binding protein, interacts with the C-terminal heparin-binding domain of vitronectin, and when bound to PspC, it retains complement inhibitory function. Conclusion: PspC is an adhesin for vitronectin, and the PspC-vitronectin interaction inhibits immune attack. Significance: The PspC-vitronectin interaction provides new insights into pneumococcal adhesion and complement inhibition.