The cholinergic system in Alzheimer's disease

Kása, P.; Rakonczay, Zoltán; Gulya, Károly

doi:10.1016/s0301-0082(97)00028-2

Cited by 365 publications

(206 citation statements)

References 217 publications

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“…More recently, studies of other pathways linked to AD, including those involving amyloid proteins (Selkoe, 1994), Tau protein (Hellstrom-Lindahl, 2000), and inflammation (Breitner, 1996), have supplanted the cholinergic hypothesis; however, loss of high affinity nicotine binding sites, measured in postmortem tissue or by PET imaging, remains a consistent marker of AD (Nordberg et al, , 1997Kasa et al, 1997;Rusted et al, 2000). A comparable decrease in the binding of other nicotinic agonists has been seen in the brains of patients with AD, including acetylcholine in the presence of atropine, methyl-carbamylcholine, cytisine, epibatidine, and ABT418 (Warpman and Nordberg, 1995;Gotti et al, 1997;Kasa et al, 1997). Studies in rodents suggest that nicotine and the other nicotinic agonists used to date recognize the same populations of nAChRs in the cerebral cortex (Zoli et al, 1998).…”

Section: Cholinergic Hypothesis Of Brain Aging: Studies Of Nachr Exprmentioning

confidence: 99%

Nicotinic receptors in aging and dementia

2002

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Activation of neuronal nicotinic acetylcholine receptors (nAChRs) has been shown to maintain cognitive function following aging or the development of dementia. Nicotine and nicotinic agonists have been shown to improve cognitive function in aged or impaired subjects. Smoking has also been shown in some epidemiological studies to be protective against the development of neurodegenerative diseases. This is supported by animal studies that have shown nicotine to be neuroprotective both in vivo and in vitro. Treatment with nicotinic agonists may therefore be useful in both slowing the progression of neurodegenerative illnesses, and improving function in patients with the disease. While increased nicotinic function has been shown to be beneficial, loss of cholinergic markers is often seen in patients with dementia, suggesting that decreased cholinergic function could contribute to both the cognitive deficits, and perhaps the neuronal degeneration, associated with dementia. In this article we will review the literature on each of these areas. We will also present hypotheses that might address the mechanisms underlying the ability of nAChR function to protect against neurodegeneration or improve cognition, two potentially distinct actions of nicotine.

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Section: Cholinergic Hypothesis Of Brain Aging: Studies Of Nachr Exprmentioning

confidence: 99%

Nicotinic receptors in aging and dementia

2002

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“…Deterioration of cognitive functions including learning and memory loss is a characteristic feature in aging and AD patients (Terry and Davies, 1980). In AD patients, the dysfunction of presynaptic cholinergic system is one of the causes of cognitive defi cit (Whitehouse et al, 1982;Coyle et al, 1983), in which decreased activity of enzyme choline acetyltransferase (ChAT) responsible for acetylcholine (ACh) synthesis is observed (Kasa et al, 1997;Terry and Buccafusco, 2003).…”

Section: Introductionmentioning

confidence: 99%

Improving Effect of Silk Peptides on the Cognitive Function of Rats with Aging Brain Facilitated by D-Galactose

Park¹,

Lee²,

Choi³

et al. 2011

Biomolecules and Therapeutics

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“…[2] Similarly, abnormal levels of acetylcholine, a key signalling entity in learning and memory of the CNS and in the triggering and control of muscle activity of the peripheral nervous system, may indicate disorders such as Alzheimer's disease [3] or dementia. [4] Significant effort has therefore been devoted in recent years for the development of highly sensitive and specific techniques to detect local neurotransmitter concentrations.…”

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confidence: 99%

Detection of Glutamate and Acetylcholine with Organic Electrochemical Transistors Based on Conducting Polymer/Platinum Nanoparticle Composites

et al. 2014

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The aim of the study is to open a new scope for organic electrochemical transistors based on PEDOT:PSS, a material blend known for its stability and reliability. These devices can leverage molecular electrocatalysis by incorporating small amounts of nano-catalyst during the transistor manufacturing (spin coating). This methodology is very simple to implement using the know-how of nanochemistry and results in efficient enzymatic activity transduction, in this case utilizing choline oxidase and glutamate oxidase.

Funding Agencies|EU [PIEF-GA-2011-301796]; Onnesjo foundation; Swedish Research Council [2002-4497]; Swedish Foundation for Strategic Research [IMF11-0052]; Knut and Alice Wallenberg Foundation [2012-0302]

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The cholinergic system in Alzheimer's disease

Cited by 365 publications

References 217 publications

Nicotinic receptors in aging and dementia

Nicotinic receptors in aging and dementia

Improving Effect of Silk Peptides on the Cognitive Function of Rats with Aging Brain Facilitated by D-Galactose

Detection of Glutamate and Acetylcholine with Organic Electrochemical Transistors Based on Conducting Polymer/Platinum Nanoparticle Composites

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