the choreometer: An objective test of chorea during voluntary movements

Trzepacz, Paula T.; Webb, Mark

doi:10.1016/0006-3223(87)90210-1

Cited by 8 publications

(1 citation statement)

References 8 publications

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“…Isometric force procedures have yielded intra-patient reliability coe¦cients of 0.85 (Caligiuri and Lohr 1990). Procedures which count movements such as position sensors (Trzepac and Webb 1987) or ultrasonic techniques (Resek et al 1981;Bartzokis et al 1989) are highly reliable with test-retest correlation coe¦cients greater than 0.90. Gattaz and Buchel (1993) reported an intra-subject reliability coe¦cient of 0.84, using an automated digital video image processing system which counted oral movements.…”

Section: Introductionmentioning

confidence: 99%

Reliability of an instrumental assessment of tardive dyskinesia: results from VA Cooperative Study #394

Caligiuri¹,

Lohr

Rotrosen

et al. 1997

Psychopharmacology

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Nine VA Medical Centers are participating in a 2-year double-blind placebo controlled study of antioxidant treatment for tardive dyskinesia (TD) conducted by the Department of Veteran Affairs Cooperative Studies Program. One of the principal outcome measures of this study is the score derived from the instrumental assessment of upper extremity dyskinesia. Dyskinetic hand movements are quantified by assessing the variability associated with steady-state isometric force generated by the patient. In the present report, we describe the training procedures and results of a multi-center reliability assessment of this procedure. Data from nine study centers comprising 45 individual patients with six trials each (three from left hand and three from right hand) were reanalyzed by an independent investigator and the results were subjected to reliability assessment. For the statistic of interest (average coefficient of variation over trials 2 and 3 for each hand, then take the larger of these two values), we found very high intraclass correlation coefficients for reliability over all patients across sites (ICC = 0.995). We also calculated the reliability of the measures across trials within patient for each combination of hand (right, left, dominant), rater group (site, control), and trials set (all three, trials 2 and 3). For a given hand and trial set, the reliability of the site raters was similar to that of the control. This study demonstrates that instrumental measures for the assessment of dyskinesia are reliable and can be implemented in multi-center studies with minimal training.

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Section: Introductionmentioning

confidence: 99%

Reliability of an instrumental assessment of tardive dyskinesia: results from VA Cooperative Study #394

Caligiuri¹,

Lohr

Rotrosen

et al. 1997

Psychopharmacology

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A comparison of neurological, metabolic, structural, and genetic evaluations in persons at risk for Huntington's disease

Grafton

Mazziotta

Pahl

et al. 1990

Annals of Neurology

109

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We compared four diagnostic data sets for the assessment of individuals at risk for Huntington's disease. Fifty-four chorea-free persons were evaluated by neurological examination, positron emission tomography measurement of glucose metabolism, radiographic computerized tomographic measurement of caudate size, and genetic testing at the polymorphic DNA loci D4S10, D4S43, and D4S125. Twelve (22%) persons had abnormal caudate metabolism, 6 (11%) had subtle abnormalities of motor control, and 7 (13%) had computed tomographic evidence of caudate atrophy, compared with an expected gene frequency of 34% for this population. In 20 persons with unambiguous genetic test results or the subsequent phenotypic expression of Huntington's disease (chorea), there was a greater sensitivity of the positron emission tomographic measurement of caudate metabolism (75%) relative to computed tomography (33%) or the clinical examination (17%) for the determination of a subpopulation of probable Huntington's disease gene carriers. Hypometabolism of the putamen and globus pallidus, and hypermetabolism of the precentral gyrus were also associated with a high probability of carrying the Huntington's disease gene. The findings support the hypothesis that abnormalities of cerebral metabolism precede clinical or structural (computed tomographic) abnormalities in gene-positive individuals at risk for Huntington's disease.

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Comparison of somatosensory evoked potentials with striatal glucose consumption measured by positron emission tomography in the early diagnosis of huntington's disease

et al. 1993

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Both somatosensory evoked potentials (SEP) and striatal glucose consumption (rCMRGlc) measured by positron emission tomography (PET) have been reported to be abnormal early in the course of Huntington's disease (HD). To compare their diagnostic value, SEP and rCMRGlc were measured in a group of 18 first degree off-spring of HD families: 6 had manifest HD with chorea and the remaining 12 individuals were chorea-free subjects at risk for HD. In five patients with manifest disease, both SEP and striatal rCMRGlc were significantly abnormal, defined in SEP as having either a bilaterally absent frontal N30 amplitude or a reduction of the parietal N20/P25 amplitude below 1 microV on at least one side; in PET as exhibiting a reduction of the cerebellar ratio (CR) of both caudate and lentiform rCMRGlc below the 99% confidence limits of these variables determined in 20 normal volunteers. The remaining patient with manifest HD had questionably abnormal SEP and significantly reduced indices of striatal rCMRGlc. The five persons at risk for HD who had normal SEP also had normal striatal rCMRGlc; those three at-risk patients with abnormal SEP also had a reduction of the CR of both caudate and lentiform rCMRGlc. Of the remaining four individuals at risk for HD who had questionably abnormal SEP, three had CR values of striatal rCMRGlc in the normal range and one a reduction of the CR of lentiform rCMRGlc. In at-risk patients, the SEP diagnosis correlated significantly with caudate (r = -0.8; p < 0.002) and lentiform (r = -0.76; p < 0.005) rCMRGlc. These data indicate a parallel deterioration of SEP and striatal rCMRGlc early in the course of HD even before the development of chorea.

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the choreometer: An objective test of chorea during voluntary movements

Cited by 8 publications

References 8 publications

Reliability of an instrumental assessment of tardive dyskinesia: results from VA Cooperative Study #394

Reliability of an instrumental assessment of tardive dyskinesia: results from VA Cooperative Study #394

A comparison of neurological, metabolic, structural, and genetic evaluations in persons at risk for Huntington's disease

Comparison of somatosensory evoked potentials with striatal glucose consumption measured by positron emission tomography in the early diagnosis of huntington's disease

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