The chronic bronchitis phenotype in chronic obstructive pulmonary disease

Kim, Victor; Criner, Gerard J.

doi:10.1097/mcp.0000000000000145

Cited by 75 publications

(69 citation statements)

References 79 publications

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“…There were 27.8% of current smokers in our study, and the percentage of current smokers was higher in patients with CB compared to those without CB (37.0% vs. 28.1%; P=0.02; data not shown). This result is compatible with that of a previous cohort study (9,13,24,26).…”

Section: Discussionsupporting

confidence: 83%

“…However, there are controversies concerning whether chronic cough and sputum production alone can be a clinical COPD phenotype because conflicting data exist regarding the association between COPD and clinical manifestations and outcomes (10)(11)(12). Moreover, the definition of CB remains to be confirmed, such that CB prevalence differs according to the definition used (13).…”

Section: Introductionmentioning

confidence: 99%

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Lower diffusing capacity with chronic bronchitis predicts higher risk of acute exacerbation in chronic obstructive lung disease

Lee¹,

Kim²,

Lee³

et al. 2016

J. Thorac. Dis.

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Background: This study was designed to evaluate the effect of chronic bronchitis (CB) symptoms and degree of emphysema in a multicenter Korean cohort. Methods: From April 2012 to May 2015, patients diagnosed with chronic obstructive lung disease (COPD) who were aged above 40 years at 46 hospitals throughout Korea were enrolled. All of the patients were classified according to CB symptoms and the diffusing capacity of the lung for carbon monoxide (DL CO ); demographic data, symptom scores, and the result of lung function tests and exacerbations were then analyzed. Results: A total of 812 patients were enrolled. Among these patients, 285 (35.1%) had CB symptoms.

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Section: Discussionsupporting

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Lower diffusing capacity with chronic bronchitis predicts higher risk of acute exacerbation in chronic obstructive lung disease

Lee¹,

Kim²,

Lee³

et al. 2016

J. Thorac. Dis.

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“…Sedangkan menurut (Tabrani, 2010), umur berpengaruh terhadap elastisitas paru, dan penurunan elastisitas paru akan berpengaruh pada terjadinya PPOK. Sementara itu kejadian penyakit paru obstruksi kronik banyak ditemui pada kelompok umur 44 -65 tahun 16 .…”

Section: Hasil Dan Pembahasanunclassified

“…Tabel II menunjukkan bahwa, terdapat beberapa item pertanyaan yang tidak memenuhi kriteria validitas konvergen yaitu pada item pertanyaan nomor 3, 6 (domain gejala), item pertanyaan nomor 16 Pada Tabel III menunjukkan bahwa tidak ada perbedaan yang signifikan dalam 3 domain dari SGRQ versi Indonesia berdasarkan jenis kelamin pada laki-laki dan perempuan (sig ≥ 0,05). Pada Tabel IV terdapat perbedaan yang signifikan pada domain gejala 0,047 dari SGRQ versi Indonesia berdasarkan umur 17-48 tahun dengan 49-80 tahun.…”

Section: Hasil Dan Pembahasanunclassified

Validation of St. George's Respiratory Questionnaire (SGRQ) in Chronic Obstructive Pulmonary Disease (COPD) at Respira Lung Hospital Yogyakarta

Pratiwi

Perwitasari

2017

J. Manaj. dan Pelayanan Farm.

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ABSTRAKPrevalensi Penyakit Paru Obstruktif Kronis (PPOK) di Indonesia semakin meningkat. Diperkirakan pada tahun 2020 PPOK akan menjadi penyebab kematian ketiga di dunia. Salah satu tujuan terapi dari PPOK sebagai penyakit kronik adalah meningkatkan kualitas hidup pasien. Penelitian ini bertujuan untuk memvalidasi kuesioner St. George's Respiratory Questionnaire (SGRQ) versi Indonesia sebagai instrumen untuk mengukur kualitas hidup pasien PPOK di RS Paru Respira, Yogyakarta. Penelitian ini menggunakan rancangan potong lintang yang dilakukan di RS Paru Respira, Yogyakarta dari bulan Juni-Juli 2016. Pengumpulan data dilakukan dengan menggunakan rekam medik pasien dan wawancara secara langsung kepada pasien menggunakan kuesioner SGRQ. Subyek penelitian yang digunakan adalah pasien PPOK yang berusia 17-80 tahun. Analisis statistik dilakukan untuk mengetahui validitas konstruk, known-group dan reliabilitas kuesioner. Sejumlah 41 responden berpartisipasi dalam penelitian ini. Kuesioner SgRQ versi Indonesia memenuhi kriteria reliabilitas dengan nilai Cronbach alpha mencapai > 0.7 untuk domain gejala, aktivitas dan dampak. Terdapat 17 pertanyaan dan 10 pertanyaan pada ketiga domain yang tidak memenuhi validitas konvergen dan diskriminan. Perbedaan bermakna muncul pada domain gejala berdasar kelompok umur 17-48 dan 49-80 tahun (p<.05). Kuesioner The SGRQ versi Indonesia belum memenuhi kriteria validitas namun masih memenuhi kriteria reliabel. Kata kunci: SGRQ, Indonesia, PPOK, validitas ABSTRACTThe prevalence of COPD in Indonesia is getting increase. Over the world, COPD is predicted to be the third cause of death in 2020. As the chronic disease, quality of life became one of the outcome treatments of COPD. This research was aimed to validate Indonesian version of St. George's Respiratory Questionnaire (SGRQ) Indonesian. This study used cross sectional design approach from June to July 2016, conducted in Respira Lung Hospital, Yogyakarta. Data was collected from medical record and direct interviews to patients using SGRQ. An inclusion criterion was adult patients with COPD. Some statistical tests were performed to analyze construct validity, known group validity and reliability of Indonesian version of SGRQ. We recruited 41 respondents. The SGRQ meet reliability criteria with the value of Cronbach alpha are > 0.7 for symptom, activity and impact domains. There are 17 questions and 10 questions in symptom, activity and impact domains which do not meet convergent and discriminant validity. The significant difference is found in symptom domain for the 17-48 and 49-80 year age. The SGRQ Indonesian version is not valid enough to be used in clinical practice but still reliable.

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“…The recognition that COPD is a multifaceted entity is far from novel [10][11][12], but it is only recently that its different clinical presentations were identified and integrated as relevant potential markers of symptomatology, response to treatment and prognosis: the so-called COPD phenotypes [13][14][15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

The clinical relevance of the emphysema-hyperinflated phenotype in COPD

et al. 2015

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The classification of chronic pulmonary obstructive disease (COPD) into clinical and pathophysiological subsets is not new, but increasing data is available on the relation of these different phenotypes to clinically meaningful outcomes. This review focuses on the "emphysema-hyperinflation" (EH) phenotype, which is characterised by a prominent loss of lung elastic recoil and hyperinflation burden that translates into marked exercise intolerance and a heightened sense of dyspnoea. Although no single genetic profile has been associated with the EH phenotype, recent data have shown that certain single nucleotide polymorphisms, such as DNAH5, appear to have an effect on the preferential development of hyperinflation in smokers. Static and dynamic hyperinflation are hallmarks of the EH phenotype, and abnormal increases in resting lung function indices such as total lung capacity (TLC), functional residual capacity (FRC) and inspiratory to TLC ratio (IC/TLC) seem more associated with the clinical EH phenotype than others markers of gas trapping. An increased level of dyspnoea on exertion and exercise intolerance are also characteristic of the EH presentation and are likely related in part to critical mechanical constraints imposed on tidal volume expansion in situations where ventilatory demands are increased, but also possibly on cardiac and hemodynamic anomalies related to emphysema and hyperinflation. Importantly, the clinical relevance of the EH phenotype is underlined by the finding that indices of hyperinflation such as IC/TLC and residual volume (RV) can be used as independent predictors of mortality in patients with COPD. Treatment of patients with the EH phenotype should primarily focus on smoking cessation and maximal bronchodilator therapy. New long-acting combined bronchodilators options provide clinicians with safe and effective ways to address the hyperinflation issue in this population. Pulmonary rehabilitation also has a positive impact on exercise tolerance, quality of life and hyperinflation, and should be routinely considered in patients with EH presentation that remain symptomatic despite optimal treatment, whereas as lung volume reduction techniques should be reserved for highly selected patients.

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The chronic bronchitis phenotype in chronic obstructive pulmonary disease

Cited by 75 publications

References 79 publications

Lower diffusing capacity with chronic bronchitis predicts higher risk of acute exacerbation in chronic obstructive lung disease

Lower diffusing capacity with chronic bronchitis predicts higher risk of acute exacerbation in chronic obstructive lung disease

Validation of St. George's Respiratory Questionnaire (SGRQ) in Chronic Obstructive Pulmonary Disease (COPD) at Respira Lung Hospital Yogyakarta

The clinical relevance of the emphysema-hyperinflated phenotype in COPD

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