The Ciliary Body: A Potential Multifaceted Functional Neuroendocrine Unit

Yorio, Thomas; Prasanna, Ganesh; Coca‐Prados, Miguel

doi:10.1016/b978-012370585-3.50006-6

Cited by 5 publications

(1 citation statement)

References 99 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…AH is secreted into the posterior chamber by the non-pigmented epithelial cells of the ciliary processes, and serves to supply critical nutrients and signaling molecules, and to remove metabolic waste from the cornea, lens, and trabecular meshwork. Though the total amount of protein in the anterior chamber is less than 1% (w/v) due to the functional blood aqueous barrier 4 , the aqueous humor is enriched with proteins secreted by intraocular structures from both the anterior and posterior segments 11 . It is also thus feasible to hypothesize that systemic disorders, genetic conditions, or perturbations to ocular integrity and health may all adversely influence expression of proteins in the aqueous humor and other ocular tissues 12 .…”

Section: Introductionmentioning

confidence: 99%

Proteomic profile analysis of plasma and aqueous humor from glaucoma and non-glaucomatous patients

Pessuti,

Huang,

Banks

et al. 2024

Preprint

Self Cite

View full text Add to dashboard Cite

Purpose: Glaucoma, a multifactorial ocular neuropathic and age associated disease, can lead to irreversible vision loss. Diagnosis involves assessing optic cupping (increased cup-to-disc ratios) and structural changes (like retinal nerve fiber layer thinning) through clinical imaging. Elevated intraocular pressure (IOP) is commonly associated with glaucoma, but not always. However, understanding disease progression is hindered by limited access to donor ocular tissue and consistent clinical data. Our study focuses on live patient samples, analyzing their proteome for potential biomarkers to enhance precise diagnosis and monitor glaucoma progression. Methods: Aqueous humor (AH) samples were collected from 36 glaucoma patients (17 male, 19 female), and 35 non-glaucomatous control patients (16 male, 19 female) undergoing cataract surgery. The protein profile was compared using the SOMAscan assay system for proteome profiling. From glaucomatous donors, significant correlations between IOP and cup-to-disc ratios to proteome differences were identified. Results: Correlations in proteins between plasma and AH were identified. These proteins were enriched in pathways related to vascular integrity, inflammatory response, humoral & adaptive immune response, cell-cell & cell-matrix adhesion, and complement activation. Glaucomatous AH exhibited increased protein levels in general. Neurofilament light chain (NEFL) protein correlated with elevated IOP and inflammatory markers, but not with cup-to-disc ratios. Conclusions: Together, our data demonstrate that the proteins identified in this study from glaucomatous donors correspond to both markers of neurodegeneration and those that may inhibit cell proliferation or disrupt vascular integrity.

show abstract

Section: Introductionmentioning

confidence: 99%

Proteomic profile analysis of plasma and aqueous humor from glaucoma and non-glaucomatous patients

Pessuti,

Huang,

Banks

et al. 2024

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

Ophthalmological Preparations

Dolak¹,

Lever²,

Marsh³

et al. 2000

Ullmann's Encyclopedia of Industrial Chemistry

View full text Add to dashboard Cite

The article contains sections titled: 1. Introduction 2. Anesthetics 2.1. Topical Anesthetics 2.2. Regional Anesthetics 3. Antimicrobial Agents 3.1. Antibacterial Agents 3.1.1. Sulfonamides 3.1.2. β‐Lactam Antibiotics 3.1.2.1. Penicillins 3.1.2.2. Cephalosporins 3.1.3. Tetracycline Antibiotics 3.1.4. Aminoglycoside Antibiotics 3.1.5. Polypeptide Antibiotics 3.1.6. Miscellaneous Antimicrobial Agents 3.2. Antifungal Agents 3.3. Antiprotozoal Agents 3.4. Antiviral Agents 4. Anti‐inflammatory Agents 4.1. Corticosteroids 4.2. Miscellaneous Anti‐inflammatory Agents 5. Antiglaucomatous Agents 5.1. Sympathomimetic Drugs 5.2. β‐Adrenergic Blocking Agents 5.3. Carbonic Anhydrase Inhibitors 5.4. Hyperosmotic Agents 5.5. Miotics (Parasympathomimetic Agents) 5.5.1. Cholinergic Agonists 5.5.2. Anticholinesterases 6. Mydriatics and Cycloplegics 6.1. Sympathomimetics 6.2. Parasympatholytics 7. Vasoactive (Adrenergic) Agents 8. Diagnostic Agents 9. Dry Eye Medications 10. Miscellaneous Ophthalmic and Contact Lens Preparations 10.1. Disinfectants and Preservatives 10.1.1. Biguanides 10.1.2. Mercurial Preservatives 10.1.3. Quaternary Ammonium Compounds 10.1.4. Miscellaneous Disinfectants and Preservatives 10.2. Contact Lens Cleaners and Rewetting Agents 10.2.1. Surfactant Cleaners 10.2.2. Enzymatic Cleaners

show abstract

Eye: Proteomics

Steely¹,

Clark²

2009

Encyclopedia of Life Sciences

View full text Add to dashboard Cite

Vision is our most precious sense, and numerous ocular diseases, including age‐related macular degeneration, glaucoma and diabetic retinopthay, are responsible for visual impairment and blindness in hundreds of millions of individuals worldwide. In the past several years, a number of advances have been made to better understand ocular biology and diseases. Research in ocular proteomics of ocular tissues and cells such as the trabecular meshwork, retina, optic nerve head, retinal pigment epithelium, cornea, lens, sclera, tears, aqueous humour and vitreous humour, has allowed the identification of eye proteins and protein modifications that are involved in ocular development, ageing and disease. This provides an important foundation for better understanding ocular biology and disease pathogenesis. Key Concepts: The eye is a unique sensory organ. A wide variety of proteomics techniques are being used to identify proteins and protein modifications that are involved in ocular development, ageing and a wide variety of ocular diseases. Eye proteomics can be very challenging due to the very limited quantity of ocular tissues and fluids available for analysis. Posttranslational protein modifications are commonly associated with a variety of ocular diseases, including glaucoma, macular degeneration and cataracts. Serum proteomics is being used to examine systemic effects of specific ocular diseases.

show abstract

The Ciliary Body: A Potential Multifaceted Functional Neuroendocrine Unit

Cited by 5 publications

References 99 publications

Proteomic profile analysis of plasma and aqueous humor from glaucoma and non-glaucomatous patients

Proteomic profile analysis of plasma and aqueous humor from glaucoma and non-glaucomatous patients

Ophthalmological Preparations

Eye: Proteomics

Contact Info

Product

Resources

About