The circ_FAM53B-miR-183-5p-CCDC6 axis modulates the malignant behaviors of papillary thyroid carcinoma cells

Zhang, Chong; Gu, Huxia; Liu, Dingrong; Tong, Fuyun; Wei, Huijie; Zhou, Dan; Fang, Jing; Dai, Xiaolu; Tian, Haibo

doi:10.1007/s11010-022-04465-6

Cited by 5 publications

(4 citation statements)

References 33 publications

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“…PIK3CA, the initial component of the AKT/mTOR cascade [ 64 ]. CCDC6, protein 6 containing an antenna domain, interacts with CREB1 (reaction element binding protein cAMP 1) and suppresses its transcriptional activity [ 65 ].…”

Section: Resultsmentioning

confidence: 99%

“…PIK3CA activates AKT/mTOR signaling and operates the protein’s metabolism as a key mechanism of cells adaptation and survival [ 64 ]. The novel genetic marker is CCDC6, the components of the gene’s translocation in PTC [ 65 ]. It should be noted that the role of most molecular and genetic factors is still unknown, which causes the unpredictable pattern of behavior of tumor cells and leads to the low treatment response.…”

Section: Discussionmentioning

confidence: 99%

“…It is known that the tumor invasion is the cancer progression, associated with the intracellular signaling, transcription and growth factors changes [ 12 , 37 , 65 ] and reflected in the aggressive tumor behavior. In addition, a high hsa-miR-125b expression was associated with the BRAF V600E status, which was disclosed in the results of the experiment on melanoma in cell culture [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

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Autophagy-Related MicroRNA: Tumor miR-125b and Thyroid Cancers

Спирина

Kovaleva

Chizhevskaya

et al. 2023

Genes

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Background: Autophagy is a stress response mechanism that causes cellular components to degrade. Its defects were associated with multiple pathologies, including cancers. Thyroid cancer is known to be the most prevalent form of malignant neoplasm among endocrine tumors. The aim of the study was to seek and comprehensively explore the role of autophagy related genes and proteins play in thyroid cancers through bioinformatics analysis with their detection in the tissue samples. Methods: Bioinformatics analysis was performed to investigate autophagy related proteins and genes involvement in thyroid cancer progression. The experimental verification was done in cancer samples of one hundred and three patients with thyroid pathology included in the study. The miR-125blevel was detected by PCR in real time. Results and discussion: The bioinformatics analysis verified the miR-125b as a regulatory mechanism in autophagy. Its expression in patients with PTC was reduced by 6.75 times in cancer patients compared to the patients with benign tumors. The BRAFV600E mutations were associated with a decrease in hsa-miR-125b expression by 12.67 times compared to tumors with the wild-type gene. Conclusions: Our findings revealed involvement of the autophagy related proteins in cancer progression. The significant mechanisms of regulation are non-coding RNA sequences implicated in a variety of oncogenic processes. We found that miR-125b is a potential maker in thyroid cancer invasion, BRAV600E mutational status and risk of recurrence.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Autophagy-Related MicroRNA: Tumor miR-125b and Thyroid Cancers

Спирина

Kovaleva

Chizhevskaya

et al. 2023

Genes

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“…The miR-1 has been reported to co-regulates the target gene histone deacetylase 4 (HDAC4) with miR-133a, which is involved in muscle development regulation [47]. MiR-183 plays a regulatory role in many human cancers, including colorectal, melanoma, prostate, and breast cancer, as well as osteoporosis [48][49][50][51][52]. However, in this study, many target genes corresponding to miR-183-x and miR-133, such as mitf, tyr, tyrp1, agouti-signaling protein (asip), melanocortin 1 receptor (mc1r), transcription factor sox10, and pax3 are all directly or indirectly involved in the regulation of melanin synthesis [53][54][55][56][57].…”

Section: Discussionmentioning

confidence: 99%

Identification and Characterization of microRNAs in Morphological Color Change of Polychromatic Midas Cichlids (Amphilophus citrinellus)

Wu,

Mu,

Liu

et al. 2024

Fishes

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As a representative genetic and economic trait, pigmentation has a strong impact on speciation and adaptation. However, information and reports on microRNAs (miRNAs) associated with pigmentation remain limited. The Midas cichlid fish, with three typical distinct stages of body color pattern, “black-gray-gold”, is an ideal model system for investigating pigmentation traits. In this study, miRNA libraries from scale tissues with the attached epidermis of Midas cichlids at three distinct stages of color transformation, black (B), transition (T), and gold (G), were sequenced using Illumina sequencing technology. In total, 53 (B vs. G), 88 (B vs. T), and 57 (T vs. G) miRNAs were differentially expressed between the respective groups. Target genes of the identified miRNAs were predicted, and the results showed that multiple target genes were related to pigmentation and pigment–cell differentiation. The miRNA–mRNA regulatory network suggests that miR-183-x and miR-133-x were predicted to be involved in regulating morphological color changes in Midas cichlids. The results advance our understanding of potential functions of miRNAs in skin pigment differentiation and early skin color fading of fishes.

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Tumour circular RNAs elicit anti-tumour immunity by encoding cryptic peptides

Huang,

Zhu,

et al. 2023

Nature

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The circ_FAM53B-miR-183-5p-CCDC6 axis modulates the malignant behaviors of papillary thyroid carcinoma cells

Cited by 5 publications

References 33 publications

Autophagy-Related MicroRNA: Tumor miR-125b and Thyroid Cancers

Autophagy-Related MicroRNA: Tumor miR-125b and Thyroid Cancers

Identification and Characterization of microRNAs in Morphological Color Change of Polychromatic Midas Cichlids (Amphilophus citrinellus)

Tumour circular RNAs elicit anti-tumour immunity by encoding cryptic peptides

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