The Circadian Biology of Heart Failure

Jamal, Nadim El; Lordan, Ronan; Teegarden, Sarah L.; Großer, Tilo; FitzGerald, Garret A.

doi:10.1161/circresaha.122.321369

Cited by 27 publications

(12 citation statements)

References 178 publications

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“…Cardiac physiology and contractility exhibit diurnal rhythms that can be partly or entirely due to circadian mechanisms. 142 Multiple lines of evidence suggest alterations in the circadian biology contribute to the pathogenesis of heart failure. 142 Human hearts express clock genes, several of which display daily rhythms in expression.…”

Section: Myocardial Infarctionmentioning

confidence: 99%

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Hypertension: Causes and Consequences of Circadian Rhythms in Blood Pressure

Faraci,

Scheer

2024

Circulation Research

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Hypertension is extremely common, affecting approximately 1 in every 2 adults globally. Chronic hypertension is the leading modifiable risk factor for cardiovascular disease and premature mortality worldwide. Despite considerable efforts to define mechanisms that underlie hypertension, a potentially major component of the disease, the role of circadian biology has been relatively overlooked in both preclinical models and humans. Although the presence of daily and circadian patterns has been observed from the level of the genome to the whole organism, the functional and structural impact of biological rhythms, including mechanisms such as circadian misalignment, remains relatively poorly defined. Here, we review the impact of daily rhythms and circadian systems in regulating blood pressure and the onset, progression, and consequences of hypertension. There is an emphasis on the impact of circadian biology in relation to vascular disease and end-organ effects that, individually or in combination, contribute to complex phenotypes such as cognitive decline and the loss of cardiac and brain health. Despite effective treatment options for some individuals, control of blood pressure remains inadequate in a substantial portion of the hypertensive population. Greater insight into circadian biology may form a foundation for novel and more widely effective molecular therapies or interventions to help in the prevention, treatment, and management of hypertension and its related pathophysiology.

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Section: Myocardial Infarctionmentioning

confidence: 99%

“…142 Multiple lines of evidence suggest alterations in the circadian biology contribute to the pathogenesis of heart failure. 142 Human hearts express clock genes, several of which display daily rhythms in expression. 143 Altered patterns of expression of circadian clock components occur in human hearts with cardiomyopathy.…”

Section: Myocardial Infarctionmentioning

confidence: 99%

Hypertension: Causes and Consequences of Circadian Rhythms in Blood Pressure

Faraci,

Scheer

2024

Circulation Research

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“…In the cardiovascular system, the circadian clock regulates several key mechanisms such as blood pressure (Costello & Gumz, 2021), heart rate (El Jamal et al, 2023), and cardiac contractility (Latimer & Young, 2022). BMAL1 expression is crucial for mitochondrial activities and cardiac function, and its deletion in human embryonic stem F I G U R E 2 Alterations in the core-clock machinery induce expression variations in clock-regulated genes associated with aging on Earth and increased risk of health problems due to spaceflight.…”

Section: Cardiovascular System and Circadian Regulationmentioning

confidence: 99%

Circadian regulation in aging: Implications for spaceflight and life on earth

et al. 2023

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Alterations in the circadian system are characteristic of aging on Earth. With the decline in physiological processes due to aging, several health concerns including vision loss, cardiovascular disorders, cognitive impairments, and muscle mass loss arise in elderly populations. Similar health risks are reported as “red flag” risks among astronauts during and after a long‐term Space exploration journey. However, little is known about the common molecular alterations underlying terrestrial aging and space‐related aging in astronauts, and controversial conclusions have been recently reported. In light of the regulatory role of the circadian clock in the maintenance of human health, we review here the overlapping role of the circadian clock both on aging on Earth and spaceflight with a focus on the four most affected systems: visual, cardiovascular, central nervous, and musculoskeletal systems. In this review, we briefly introduce the regulatory role of the circadian clock in specific cellular processes followed by alterations in those processes due to aging. We next summarize the known molecular alterations associated with spaceflight, highlighting involved clock‐regulated genes in space flown Drosophila, nematodes, small mammals, and astronauts. Finally, we discuss common genes that are altered in terms of their expression due to aging on Earth and spaceflight. Altogether, the data elaborated in this review strengthen our hypothesis regarding the timely need to include circadian dysregulation as an emerging hallmark of aging on Earth and beyond.

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“…4 This reflects behavior, environmental rhythms, and endogenous circadian variation in physiological mechanisms from blood clotting 5 to cardiac arrhythmias. 6 However, although there has been extensive study of diurnal variation (ie, the nonlinear combination of endogenous circadian and evoked changes from sleep/wake state, activity levels, posture, eating, and other factors) in systemic hemodynamics, 7,8 there has been limited focus on diurnal variation in cerebral blood flow (CBF) and its dependence on both systemic physiology and cerebrovascular regulatory mechanisms.…”

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confidence: 99%

Circadian and Diurnal Regulation of Cerebral Blood Flow

Webb,

Klerman,

Mandeville

2024

Circulation Research

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Circadian and diurnal variation in cerebral blood flow directly contributes to the diurnal variation in the risk of stroke, either through factors that trigger stroke or due to impaired compensatory mechanisms. Cerebral blood flow results from the integration of systemic hemodynamics, including heart rate, cardiac output, and blood pressure, with cerebrovascular regulatory mechanisms, including cerebrovascular reactivity, autoregulation, and neurovascular coupling. We review the evidence for the circadian and diurnal variation in each of these mechanisms and their integration, from the detailed evidence for mechanisms underlying the nocturnal nadir and morning surge in blood pressure to identifying limited available evidence for circadian and diurnal variation in cerebrovascular compensatory mechanisms. We, thus, identify key systemic hemodynamic factors related to the diurnal variation in the risk of stroke but particularly identify the need for further research focused on cerebrovascular regulatory mechanisms.

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The Circadian Biology of Heart Failure

Cited by 27 publications

References 178 publications

Hypertension: Causes and Consequences of Circadian Rhythms in Blood Pressure

Hypertension: Causes and Consequences of Circadian Rhythms in Blood Pressure

Circadian regulation in aging: Implications for spaceflight and life on earth

Circadian and Diurnal Regulation of Cerebral Blood Flow

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