The Circadian Clock and Obesity

Sebti, Yasmine; Hebras, Aurore; Pourcet, Benoît; Staels, Bart; Duez, Hélène

doi:10.1007/164_2021_579

Cited by 5 publications

(1 citation statement)

References 163 publications

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“…Further and deeper research needs to be performed in order to find new approaches for ameliorating metabolic disorders by targeting biological clock and circadian synchronization. Recent research conducted in vitro on cultured hepatocytes showed that BMAL1 and CLOCK play an important role in the regulation of hepatic lipid homeostasis by modulating the SREBP1c/PPARγ signaling pathway [26], confirming the significant role of circadian rhythm in MASLD development and progression [27][28][29].…”

Section: The Role Of the Circadian Clock In Insulin Resistance And Ma...mentioning

confidence: 86%

The Interconnection between Hepatic Insulin Resistance and Metabolic Dysfunction-Associated Steatotic Liver Disease—The Transition from an Adipocentric to Liver-Centric Approach

Vesković,

Šutulović,

Hrnčić

et al. 2023

CIMB

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The central mechanism involved in the pathogenesis of MAFLD is insulin resistance with hyperinsulinemia, which stimulates triglyceride synthesis and accumulation in the liver. On the other side, triglyceride and free fatty acid accumulation in hepatocytes promotes insulin resistance via oxidative stress, endoplasmic reticulum stress, lipotoxicity, and the increased secretion of hepatokines. Cytokines and adipokines cause insulin resistance, thus promoting lipolysis in adipose tissue and ectopic fat deposition in the muscles and liver. Free fatty acids along with cytokines and adipokines contribute to insulin resistance in the liver via the activation of numerous signaling pathways. The secretion of hepatokines, hormone-like proteins, primarily by hepatocytes is disturbed and impairs signaling pathways, causing metabolic dysregulation in the liver. ER stress and unfolded protein response play significant roles in insulin resistance aggravation through the activation of apoptosis, inflammatory response, and insulin signaling impairment mediated via IRE1/PERK/ATF6 signaling pathways and the upregulation of SREBP 1c. Circadian rhythm derangement and biological clock desynchronization are related to metabolic disorders, insulin resistance, and NAFLD, suggesting clock genes as a potential target for new therapeutic strategies. This review aims to summarize the mechanisms of hepatic insulin resistance involved in NAFLD development and progression.

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Section: The Role Of the Circadian Clock In Insulin Resistance And Ma...mentioning

confidence: 86%

The Interconnection between Hepatic Insulin Resistance and Metabolic Dysfunction-Associated Steatotic Liver Disease—The Transition from an Adipocentric to Liver-Centric Approach

Vesković,

Šutulović,

Hrnčić

et al. 2023

CIMB

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Circadian regulation of liver function: from molecular mechanisms to disease pathophysiology

Bolshette

Ibrahim

Reinke

et al. 2023

Nat Rev Gastroenterol Hepatol

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Pi̇nealektomi̇ze Siçanlarin Beyni̇nde Akuapori̇n 4 Ve 1 Ekspresyon Deği̇şi̇kli̇kleri̇: Melatoni̇ni̇n Rolü

Demir,

Başak

2024

İnönü Üniversitesi Sağlık Hizmetleri Meslek Yüksek Okulu Dergisi

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Beyinde bir sıvı değişim sistemi olan glenfatik sistem, astrositlerde akuaporin 4 (AQP4) ve ventriküler koroid pleksusta akuaporin 1 (AQP1) su kanalları ile ilişkilidir. Ayrıca beyinde sıvı homeostazının sürdürülmesinde sirkadiyen ritimlerin varlığı bildirilmiştir. Bu çalışmada sirkadiyen ritmi düzenleyen melatonin (pinealektomi ve eksojen melatonin takviyesi) ile AQP4 ve AQP1 arasındaki ilişkinin belirlenmesi amaçlanmıştır. Bu çalışmada 50 adet erkek sıçan beş gruba ayrıldı. Gruplar; kontrol, Sham Pinealektomi (Sham PX), Melatonin (MEL), Pinealektomi (PX), PX+MEL olarak belirlendi. MEL grubuna 30 gün intraperitoneal MEL (10 mg/kg/gün) enjeksiyonu, PX grubuna ise sadece PX cerrahisi uygulanmıştır. PX cerrahisi (MEL yoksunluğu) ve MEL enjeksiyonlarından sonra beyin dokusunda AQP1 ve AQP4 ifadelerindeki değişiklikler incelendi. AQP1 ve AQP4 seviyelerinde kontrol ve Sham PX grupları arasında istatistiksel olarak anlamlı bir fark yokken, PX grubunda anlamlı derecede bir azalma gözlenmiştir (p

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The Circadian Clock and Obesity

Cited by 5 publications

References 163 publications

The Interconnection between Hepatic Insulin Resistance and Metabolic Dysfunction-Associated Steatotic Liver Disease—The Transition from an Adipocentric to Liver-Centric Approach

The Interconnection between Hepatic Insulin Resistance and Metabolic Dysfunction-Associated Steatotic Liver Disease—The Transition from an Adipocentric to Liver-Centric Approach

Circadian regulation of liver function: from molecular mechanisms to disease pathophysiology

Pi̇nealektomi̇ze Siçanlarin Beyni̇nde Akuapori̇n 4 Ve 1 Ekspresyon Deği̇şi̇kli̇kleri̇: Melatoni̇ni̇n Rolü

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