The Circadian Syndrome Predicts Lower Urinary Tract Symptoms Suggestive of Benign Prostatic Hyperplasia Better Than Metabolic Syndrome in Aging Males: A 4-Year Follow-Up Study

Abstract

Background: The prevalence of lower urinary tract symptoms (LUTS) suggestive of benign prostate hyperplasia (BPH) increases in men. Although several risk factors, including metabolic syndrome (MetS) and depression, were identified, the underlying etiological factor remains unclear. Recently, circadian syndrome (CircS) was proposed as a novel risk cluster based on MetS. To compare the predictive power of the CircS and MetS for LUTS/BPH, this study was performed.Materials and Methods: In the baseline survey, 4,390 men older than 40 years from the China Health and Retirement Longitudinal Study were enrolled. Of them, 3,658 men were followed in the 2015 survey. Logistic regression was adopted to examine the relationships between CircS, MetS, and LUTS/BPH. To further verify the association, propensity score matching was used for sensitivity analyses. Moreover, the participants who had LUTS/BPH at the baseline were excluded to test the longitudinal relationships between CircS, MetS, and LUTS/BPH. In addition, we employed the receiver operating characteristic (ROC) curve analysis to compare the predictive power using the number of components of CircS and MetS. The DeLong test was used to test the disparities of area under the curves (AUCs).Results: The prevalence of CircS and MetS in aging men was 30.23 and 38.36%, respectively. The odds ratios for prevalent LUTS/BPH were 1.61 (95% CI = 1.29–2.00, P < 0.001) and 1.34 (95% CI = 1.08–1.66, P < 0.01), respectively, in aging men. This increased risk was also observed in incident LUTS/BPH. The prevalence of LUTS/BPH in normal, CircS alone, MetS alone, and both CircS and MetS groups was 6.96, 8.77, 7.83, and 10.77%, respectively. The AUCs for CircS predicting prevalent and incident LUTS/BPH were higher than those for MetS (0.582 vs. 0.556 for incident LUTS/BPH, P < 0.001; 0.574 vs. 0.561 for prevalent LUTS/BPH, P < 0.05).Conclusions: The CircS predicts both incident and prevalent LUTS/BPH better than MetS.

Longitudinal associations between sleep duration and cognitive impairment in Chinese elderly

“…Also, short sleep durations with fair sleep quality were detrimental to cognitive performance. Short sleep duration will lead to circadian dysfunction, and circadian dysfunction was associated with cognitive decline ( Xiong et al, 2021a ).…”

Genetically predicted adiponectin causally reduces the risk of chronic kidney disease, a bilateral and multivariable mendelian randomization study

“…Serum creatinine was measured by the enzymatic photometric assay, spectrophotometry, and modified kinetic Jaffe reaction in different cohorts ( Pattaro et al, 2016 ). To diagnose CKD, the cutoff value of eGFR was set as < 60 ml/min/1.73 m 2 , as in previous studies ( Xiong et al, 2021 ).…”

Genetic Evidence Supporting the Causal Role of Homocysteine in Chronic Kidney Disease: A Mendelian Randomization Study

“…The diagnosis of CKD was mainly based on the eGFR calculated by Schwartz formula (<18 years) and the CKD Epi-equation for adults (>18 years), respectively ( 16 , 17 ). The cut-off was set as eGFR < 60 ml.min –1 /1.73 m 2 ( 17 , 18 ). The summary data from the CKDGen consortium can be downloaded from the United Kingdom Medical Research Council Integrative Epidemiology Unit (MRC-IEU) Open GWAS database.…”

“…The PAGE study was performed in a non-European ancestry, such as Hispanic/Latino ( n = 22,216), African American ( n = 17,299), Asian ( n = 4,680), Native Hawaiian ( n = 3,940), Native American ( n = 652), or other ( n = 1,052) ( 15 ). CKD was defined as an eGFR (estimated by the CKD Epi-equation) < 60 ml.min –1 /1.73 m 2 ( 17 , 18 ). Different from the CKDGen consortium, in the PAGE study, CKD patients with end-stage renal disease were excluded.…”