The Circadian System Contributes to Apnea Lengthening across the Night in Obstructive Sleep Apnea

Butler, Matthew; Smales, Carolina; Wu, Huijuan; Hussain, Mohammad; Mohamed, Yusef A.; Morimoto, Miki; Shea, Steven A.

doi:10.5665/sleep.5166

Cited by 58 publications

(36 citation statements)

References 47 publications

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“…3 After a normal night of sleep and baseline testing, participants underwent 10 recurring 5-hours 20-min of ‘behavioural cycles’ of 2-hours 40-min of sleep opportunities and 2-hours 40-min of standardised waking episodes 3. Approximately 1 hour after each sleep episode, participants performed mild intensity cycle ergometer exercise for 15 min at 50% predicted maximal heart rate (Karvonen’s formula4).…”

Section: Methodsmentioning

confidence: 99%

Lowest perceived exertion in the late morning due to effects of the endogenous circadian system

et al. 2018

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Section: Methodsmentioning

confidence: 99%

Lowest perceived exertion in the late morning due to effects of the endogenous circadian system

et al. 2018

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“…Interestingly, the MT1 receptor mediates vasoconstriction, while the MT2 receptor mediates vasodilation [32]. By ameliorating the endogenous circadian system, melatonin may provide a novel therapeutic target for modulating sleep apnea-induced cardiovascular disease and hypertension [33]. Furthermore, melatonin shows good compliance and moderate efficiency for the treatment of SBDs.…”

Section: Effect Of Melatonin On Reducing the Complications Caused By mentioning

confidence: 99%

A review of sleep disorders and melatonin

Xie

Chen

et al. 2017

Neurological Research

315

181

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Sleep disorders are a group of conditions that affect the ability to sleep well on a regular basis and cause significant impairments in social and occupational functions. Although currently approved medications are efficacious, they are far from satisfactory. Benzodiazepines, antidepressants, antihistamines and anxiolytics have the potential for dependence and addiction. Moreover, some of these medications can gradually impair cognition. Melatonin (N-acetyl-5-methoxytryptamine) is an endogenous hormone produced by the pineal gland and released exclusively at night. Exogenous melatonin supplementation is well tolerated and has no obvious short-or long-term adverse effects. Melatonin has been shown to synchronize the circadian rhythms, and improve the onset, duration and quality of sleep. It is centrally involved in anti-oxidation, circadian rhythmicity maintenance, sleep regulation and neuronal survival. This narrative review aims to provide a comprehensive overview of various therapeutic functions of melatonin in insomnia, sleep-related breathing disorders, hypersomnolence, circadian rhythm sleep-wake disorders and parasomnias. Melatonin offers an alternative treatment to the currently available pharmaceutical therapies for sleep disorders with significantly less side effects.

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“…Although there is limited data on the role of the circadian clock in OSA (60), it may play a significant role in this disease (61)(62)(63). We found dysregulation of circadian gene expression in multiple cell types.…”

Section: Discussionmentioning

confidence: 67%

Short-term exposure to intermittent hypoxia leads to changes in gene expression seen in chronic pulmonary disease

Lee

Gulla

et al. 2020

Preprint

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Obstructive sleep apnea (OSA) results from intermittent episodes of airway collapse and hypoxia and is associated with a host of health complications including dementia, diabetes, heart failure, and stroke. Cellular mechanisms causing disease progression across multiple systems in OSA are unknown. Although it is known that pulmonary diseases share general mechanisms, such as systemic inflammation and oxidative stress, there is an incomplete understanding of the early-stage changes to the lung from OSA. Using intermittent hypoxia (IH) as a mouse model of OSA, we showed profound cell-type specific changes in genome-wide expression in the lung. With single-cell RNA analysis, we identified substantial similarities between lungs of mice exposed to IH and human lung tissue from patients with pulmonary disease--most notably pulmonary hypertension, COPD, and asthma. Many IH-responsive genes encode targets of drugs currently available to treat pulmonary disease. Present data provide insights into the initiation of specific cellular responses which drive disease progression in a model of OSA. This information can help direct therapies to the most relevant cells and molecular pathways.

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The Circadian System Contributes to Apnea Lengthening across the Night in Obstructive Sleep Apnea

Abstract: The endogenous circadian system plays an important role in the prolongation of respiratory events across the night, and might provide a novel therapeutic target for modulating sleep apnea.

Cited by 58 publications

References 47 publications

Lowest perceived exertion in the late morning due to effects of the endogenous circadian system

Lowest perceived exertion in the late morning due to effects of the endogenous circadian system

A review of sleep disorders and melatonin

Short-term exposure to intermittent hypoxia leads to changes in gene expression seen in chronic pulmonary disease

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