The circadian visual system

Morin, L.P.

doi:10.1016/0165-0173(94)90005-1

Cited by 520 publications

(415 citation statements)

References 233 publications

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“…In addition, because the terminall fields of all three major projections to the SCN (the RHT, GHT, and median raphe) arje colocalized in the core, this overlap is suggestive of synaptic contacts between the three input pathways (Morin, 1994(Morin, ., 1999Morin eta/., 1992). Thus, interconnectivity provides the means for interaction, while regulation of per expression is likely the medium (Challet et a/., 2003).…”

Section: Interactions Between Photic and Nonphotic Stimulimentioning

confidence: 99%

Differential effects of constant light on circadian clock resetting by photic and nonphotic stimuli in Syrian hamsters

Landry

Mistlberger

2005

Brain Research

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Section: Interactions Between Photic and Nonphotic Stimulimentioning

confidence: 99%

Differential effects of constant light on circadian clock resetting by photic and nonphotic stimuli in Syrian hamsters

Landry

Mistlberger

2005

Brain Research

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“…Organisms have developed diverse mechanisms for timing across different scales, the most important being circadian timing, interval timing and millisecond timing . The circadian pacemaker -which is driven by a self-sustaining oscillator with a period close to 24 h -is located in the suprachiasmatic nuclei (SCN) of the hypothalamus (Dunlap et al, 2004), and the principal signal that adjusts its activity is the light-dark cycle (Morin and Allen, 2006;Golombek and Rosenstein, 2010). The molecular mechanism of the endogenous circadian clock is comprised by interlocked transcription-translation feedback loops (Reppert and Weaver, 2002).…”

Section: Introductionmentioning

confidence: 99%

Circadian modulation of interval timing in mice

et al. 2011

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Temporal perception is fundamental to environmental adaptation in humans and other animals. To deal with timing and time perception, organisms have developed multiple systems that are active over a broad range of order of magnitude, the most important being circadian timing, interval timing and millisecond timing. The circadian pacemaker is located in the suprachiasmatic nuclei (SCN) of the hypothalamus, and is driven by a selfsustaining oscillator with a period close to 24 h. Time estimation in the second-to-minutes range -known as interval timing -involves the interaction of the basal ganglia and the prefrontal cortex. In this work we tested the hypothesis that interval timing in mice is sensitive to circadian modulations. Animals were trained following the peak-interval (PI) procedure. Results show significant differences in the estimation of 24-second intervals at different times of day, with a higher accuracy in the group trained at night, which were maintained under constant dark (DD) conditions. Interval timing was also studied in animals under constant light (LL) conditions, which abolish circadian rhythmicity. Mice under LL conditions were unable to acquire temporal control in the peak interval procedure.Moreover, short time estimation in animals subjected to circadian desynchronizations (modeling jet lag-like situations) was also affected. Taken together, our results indicate that short-time estimation is modulated by the circadian clock.© 2010 Elsevier B.V. All rights reserved. Keywords:Circadian rhythms Interval timingBasal ganglia Suprachiasmatic nuclei IntroductionTiming and time perception are fundamental to survival and goal reaching in humans and other animals. Organisms have developed diverse mechanisms for timing across different scales, the most important being circadian timing, interval timing and millisecond timing . The circadian pacemaker -which is driven by a self-sustaining oscillator with a period close to 24 h -is located in the suprachiasmatic nuclei (SCN) of the hypothalamus (Dunlap et al., 2004), and the principal signal that adjusts its activity is the light-dark cycle (Morin and Allen, 2006;Golombek and Rosenstein, 2010). The molecular mechanism of the endogenous circadian clock is comprised by interlocked transcription-translation feedback loops (Reppert and Weaver, 2002). On the other hand, the perception of shorter durations in the seconds-to-minutes range, known as interval timing, is crucial to learning, memory, decision making and other cognitive

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“…PKC plays a critical role in regulating neuronal signal transduction, and the expression of PKC in AVP-recipient cells substantiate their role in vasopressinergic signal transduction in the SCN. Besides AVP, however, several other neurotransmitter systems in the SCN may activate PKC through their receptors, for example the excitatory amino acids of the visual input or the cholinergic input from the forebrain and brain-stem [2,28]. PKC may therefore mediate intracellular cross talk between AVP and other neurotransmitter systems.…”

Section: Functional Role Of Pkc Isoforms In Scnmentioning

confidence: 99%

Distribution of AVP and Ca2+-dependent PKC-isozymes in the suprachiasmatic nucleus of the mouse and rabbit

Zee

Bult

1995

Brain Research

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Citation for published version (APA): Zee, E. A. V. D., & Bult, A. (1995). Distribution of AVP and Ca2+-dependent PKC-isozymes in the suprachiasmatic nucleus of the mouse and rabbit. Brain Research, 701(1), 99-107. https://doi.org/10.1016/0006-8993(95)00968-1 Copyright Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum. AbstractThe suprachiasmatic nucleus (SCN) is the circadian pacemaker in mammals and contains a network of argimne-vasopressin-immunoreactive (AVP-ir) neurons. AVP-recipient cells contain the Vla class of receptors linked to phosphoinositol turnover and protein kinase C (PKC). The present study describes the localization of AVP and the four Ca2+-dependent PKC-isoforms in the mouse and rabbit SCN. An estimate of the numerical density of AVP-ir neurons at the rostral, medial, and caudal level of the SCN revealed that the mouse SCN contains more than twice the number of AVP-ir neurons than the rabbit SCN. Neurons immunostained for AVP or PKC dominated in the dorsomedial and ventrolateral aspects of the mouse SCN, while the central area of the SCN revealed only weakly stained neurons. The rabbit SCN was characterized by a more homogeneous distribution of AVP-ir and PKC-ir neurons. PKCa was the most abundantly expressed isozyme in both species, whereas the presence of the other isoforms differed (mouse: PKC a > PKC/31 > > PKC/3 II > PKCT: rabbit: PKC~ > PKC/3II > PKC7 > PKC/3I). Clear PKCy-positive neurons were only observed in the rabbit SCN, while the mouse SCN predominantly contained immunolabeled fiber tracts for this PKC isozyme. Astrocytes immunoreactive for each PKC isoform were frequently encot, ntered in the rabbit SCN, but were absent in mice. Immunofluorescence double labeling showed that numerous AVP-recipient cells in the mouse SCN were immunopositive for PKCo~, and that nearly all AVP-ir neurons express PKCo~ abundantly. These results substantiate the putative role for PKC a in vasopressinergic signal transduction in the SCN. The differential expression in degree and cell lype of the CaZ+-dependent PKC-isoforms in the mouse and rabbit SCN may be related to the differences observed in circadian timekeeping between the two species.

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The circadian visual system

Cited by 520 publications

References 233 publications

Differential effects of constant light on circadian clock resetting by photic and nonphotic stimuli in Syrian hamsters

Differential effects of constant light on circadian clock resetting by photic and nonphotic stimuli in Syrian hamsters

Circadian modulation of interval timing in mice

Distribution of AVP and Ca2+-dependent PKC-isozymes in the suprachiasmatic nucleus of the mouse and rabbit

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