The circRNA CNEACR regulates necroptosis of cardiomyocytes through Foxa2 suppression

Gao, Xiangqian; Liu, Cui-Yun; Zhang, Yuhui; Wang, Yunlong; Zhou, Luqian; Li, Xinmin; Wang, Kai; Chen, Xinzhe; Wang, Tao; Ju, Jie; Wang, Fei; Wang, Shaocong; Wang, Yin; Chen, Zhaoyang; Wang, Kun

doi:10.1038/s41418-021-00872-2

Cited by 51 publications

(25 citation statements)

References 63 publications

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“…Cell death plays a critical role in the response to various stresses and the activation of the immune system. Studies have emphasized the role of deleterious inflammation and oxidative stress in various cell death modes of I/R, including apoptosis, necroptosis, and pyroptosis [40][41][42][43]. However, blocking one of these signaling pathways cannot completely ameliorate inflammation, suggesting the mutual involvement of several cell death pathways, as indicated by GO analysis of various cell types in the I/R retinas.…”

Section: Discussionmentioning

confidence: 99%

Single-cell RNA sequencing reveals a landscape and targeted treatment of ferroptosis in retinal ischemia/reperfusion injury

Wen

Liu

et al. 2022

J Neuroinflammation

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Background The aim of this study was to establish a complete retinal cell atlas of ischemia–reperfusion injury by single-cell RNA sequencing, and to explore the underlying mechanism of retinal ischemia–reperfusion injury in mice. Methods Single-cell RNA sequencing was used to evaluate changes in the mouse retinal ischemia reperfusion model. In vivo and in vitro experiments were performed to verify the protective effect of inhibiting ferroptosis in retinal ischemia–reperfusion injury. Results After ischemia–reperfusion injury, retinal cells were significantly reduced, accompanied by the activation of myeloid and a large amount of blood-derived immune cell infiltration. The IFNG, MAPK and NFKB signaling pathways in retinal neuronal cells, together with the TNF signaling pathway in myeloid give rise to a strong inflammatory response in the I/R state. Besides, the expression of genes implicating iron metabolism, oxidative stress and multiple programed cell death pathways have changed in cell subtypes described above. Especially the ferroptosis-related genes and blocking this process could apparently alleviate the inflammatory immune responses and enhance retinal ganglion cells survival. Conclusions We established a comprehensive landscape of mouse retinal ischemia–reperfusion injury at the single-cell level, revealing the important role of ferroptosis during this injury, and targeted inhibition of ferroptosis can effectively protect retinal structure and function.

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Section: Discussionmentioning

confidence: 99%

Single-cell RNA sequencing reveals a landscape and targeted treatment of ferroptosis in retinal ischemia/reperfusion injury

Wen

Liu

et al. 2022

J Neuroinflammation

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“…In some cases, they are significantly more abundant than the related linear RNAs [ 19 ]. In 2021, it was reported that the expression of a cardiac-necroptosis-associated circRNA (CNEACR) was downregulated in myocardial infarction [ 20 ], being closely related to the progression of myocardial infarction. Subsequently, in 2022, another study highlighted the selective expression of circSamd4 in fetal and neonatal cardiomyocytes [ 21 ].…”

Section: Biogenesis and Features Of Circular Rnasmentioning

confidence: 99%

Circular RNAs: Biogenesis, Biological Functions, and Roles in Myocardial Infarction

Han

Wang

et al. 2023

IJMS

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Non-coding RNAs have been excavated as important cardiac function modulators and linked to heart diseases. Significant advances have been obtained in illuminating the effects of microRNAs and long non-coding RNAs. Nevertheless, the characteristics of circular RNAs are rarely mined. Circular RNAs (circRNAs) are widely believed to participate in cardiac pathologic processes, especially in myocardial infarction. In this review, we round up the biogenesis of circRNAs, briefly describe their biological functions, and summarize the latest literature on multifarious circRNAs related to new therapies and biomarkers for myocardial infarction.

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“…The overexpression of ROR promoted the pluripotent state of GCSCs by upregulating several key stemness transcriptional factors, such as octamer-binding transcription factor 4 (OCT4), SRY-box transcription factor 2 (SOX2), and NANOG (143). Furthermore, lncRNAs MALAT1 and testis-associated highly-conserved oncogenic long noncoding RNA (THOR) have been shown to increase the stemness of GC cells by enhancing SOX2 and SOX9 mRNA stability, respectively (144)(145)(146). In addition, the upregulation of lncRNAs histocompatibility leukocyte antigen complex P5 (HCP5) and MACC1-AS1 induced via mesenchymal stem cell (MSC) co-culturing was found to enhance the stemness and drug-resistance of GC cells by droving FAO (93,147).…”

Section: Long Non-coding Rnas Influence Gastric Cancer Drug Resistance By Regulating Cancer Stem Cell Characteristicsmentioning

confidence: 99%

Long Non-Coding RNA in Gastric Cancer: Mechanisms and Clinical Implications for Drug Resistance

Liu

Yü

et al. 2022

Front. Oncol.

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Gastric cancer (GC) is the third leading cause of cancer-related deaths worldwide, with high recurrence and mortality rate. Chemotherapy, including 5-fluorouracil (5-FU), adriamycin (ADR), vincristine (VCR), paclitaxel (PTX), and platinum drugs, remains one of the fundamental methods of GC treatment and has efficiently improved patients’ prognosis. However, most patients eventually develop resistance to chemotherapeutic agents, leading to the failure of clinical treatment and patients’ death. Recent studies suggest that long non-coding RNAs (lncRNAs) are involved in the drug resistance of GC by modulating the expression of drug resistance-related genes via sponging microRNAs (miRNAs). Moreover, lncRNAs also play crucial roles in GC drug resistance via a variety of mechanisms, such as the regulation of the oncogenic signaling pathways, inhibition of apoptosis, induction of autophagy, modulation of cancer stem cells (CSCs), and promotion of the epithelial-to-mesenchymal transition (EMT) process. Some of lncRNAs exhibit great potential as diagnostic and prognostic biomarkers, as well as therapeutic targets for GC patients. Therefore, understanding the role of lncRNAs and their mechanisms in GC drug resistance may provide us with novel insights for developing strategies for individual diagnosis and therapy. In this review, we summarize the recent findings on the mechanisms underlying GC drug resistance regulated by lncRNAs. We also discuss the potential clinical applications of lncRNAs as biomarkers and therapeutic targets in GC.

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The circRNA CNEACR regulates necroptosis of cardiomyocytes through Foxa2 suppression

Cited by 51 publications

References 63 publications

Single-cell RNA sequencing reveals a landscape and targeted treatment of ferroptosis in retinal ischemia/reperfusion injury

Single-cell RNA sequencing reveals a landscape and targeted treatment of ferroptosis in retinal ischemia/reperfusion injury

Circular RNAs: Biogenesis, Biological Functions, and Roles in Myocardial Infarction

Long Non-Coding RNA in Gastric Cancer: Mechanisms and Clinical Implications for Drug Resistance

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